Results 11 to 20 of about 14,948,421 (258)

Model Organisms [PDF]

, 2020
This Element presents a philosophical exploration of the concept of the ‘model organism’ in contemporary biology. Thinking about model organisms enables us to examine how living organisms have been brought into the laboratory and used to gain a better ...
Ankeny, R.A., Leonelli, S., Ankeny, Rachel, Leonelli, Sabina   +3 more
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Harnessing the Power of Model Organisms To Unravel Microbial Functions in the Coral Holobiont

, 2022
Stony corals build the framework of coral reefs, ecosystems of immense ecological and economic importance. The existence of these ecosystems is threatened by climate change and other anthropogenic stressors that manifest in microbial dysbiosis such as ...
Michael Sweet, Ziegler, Maren, Sweet, Michael, Virginia M. Weis, Sebastian Fraune, Medina, Mónica, Weis, Virginia M., Mónica Medina, Sharp, Koty H., Giulia Puntin, Puntin, Giulia, Koty Sharp, Maren Ziegler, Fraune, Sebastian   +13 more
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Studying placebo effects in model organisms will help us understand them in humans [PDF]

, 2017
The placebo effect is widely recognized but important questions remain, for example whether the capacity to respond to a placebo is an evolved, and potentially ubiquitous trait, or an unpredictable side effect of another evolved process.
Simon C. Harvey, Harvey, S., Beedie, C., Chris J. Beedie   +3 more
core   +1 more source

Circulating Mucosal-Associated Invariant T Cells in a Large Cohort of Healthy Chinese Individuals From Newborn to Elderly

Frontiers in Immunology, 2019
Mucosal-associated invariant T (MAIT) cells, which are enriched in human blood and express a semi-invariant TCR chain, play important roles in conditions such as infectious diseases and cancer.
Pengcheng Chen, Pengcheng Chen, Wenhai Deng, Dandan Li, Tai Zeng, Ling Huang, Qun Wang, Jinli Wang, Weiguang Zhang, Xiaoxiao Yu, Deming Duan, Jinle Wang, Hong Xia, Hanbin Chen, Wesley Huang, Jingao Li, Dahong Zhang, Xiao-Ping Zhong, Xiao-Ping Zhong, Jimin Gao   +19 more
doaj   +1 more source

Improvement of Detection Method of Pasteurella pneumotropica and Its Medical Elimination in Mice

Shiyan dongwu yu bijiao yixue, 2021
ObjectiveTo modify the method for sensitive detection of Pasteurella pneumotropica in mice in routine monitoring, and to explore the feasibility of medical elimination in Pasteurella pneumotropica infected mice.MethodsThe Pasteurella pneumotropica were ...
ZHANG Tao, CUI Can, MA Guanzhong, ZHANG Aihua   +3 more
doaj   +1 more source

ATG7 Overexpression Is Crucial for Tumorigenic Growth of Bladder Cancer In Vitro and In Vivo by Targeting the ETS2/miRNA196b/FOXO1/p27 Axis

Molecular Therapy: Nucleic Acids, 2017
Human bladder cancer (BC) is the fourth most common cancer in the United States. Investigation of the strategies aiming to elucidate the tumor growth and metastatic pathways in BC is critical for the management of this disease.
Junlan Zhu, Yang Li, Zhongxian Tian, Xiaohui Hua, Jiayan Gu, Jingxia Li, Claire Liu, Honglei Jin, Yulei Wang, Guosong Jiang, Haishan Huang, Chuanshu Huang   +11 more
doaj   +1 more source

miR-29cb2 promotes angiogenesis and osteogenesis by inhibiting HIF-3α in bone

iScience, 2022
Summary: Coordination between osteogenesis and angiogenesis is required for bone homeostasis. Here, we show that miR-29cb2 is a bone-specific miRNA and plays critical roles on angiogenesis-osteogenesis coupling during bone remodeling.
Liping Ouyang, Yingxiao Sun, Dan Lv, Xiaochun Peng, Xiaoming Liu, Lei Ci, Guoning Zhang, Bo Yuan, Ling Li, Jian Fei, Jun Ma, Xuanyong Liu, Yun Liao   +12 more
doaj   +1 more source

Brain-Specific SNAP-25 Deletion Leads to Elevated Extracellular Glutamate Level and Schizophrenia-Like Behavior in Mice

Neural Plasticity, 2017
Several studies have associated reduced expression of synaptosomal-associated protein of 25 kDa (SNAP-25) with schizophrenia, yet little is known about its role in the illness.
Hua Yang, Mengjie Zhang, Jiahao Shi, Yunhe Zhou, Zhipeng Wan, Yicheng Wang, Yinghan Wan, Jun Li, Zhugang Wang, Jian Fei   +9 more
doaj   +1 more source

Comparative Genomic and Pan-Genomic Characterization of Staphylococcus epidermidis From Different Sources Unveils the Molecular Basis and Potential Biomarkers of Pathogenic Strains

Frontiers in Microbiology, 2021
Coagulase-negative Staphylococcus (CoNS) is the most common pathogen causing traumatic endophthalmitis. Among which, Staphylococcus epidermidis is the most common species that colonizes human skin, eye surfaces, and nasal cavity.
Shudan Lin, Bianjin Sun, Xinrui Shi, Yi Xu, Yunfeng Gu, Xiaobin Gu, Xueli Ma, Tian Wan, Jie Xu, Jianzhong Su, Yongliang Lou, Meiqin Zheng, Meiqin Zheng   +12 more
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A Comparative Genomic Approach to Determine the Virulence Factors and Horizontal Gene Transfer Events of Clinical Acanthamoeba Isolates

Microbiology Spectrum, 2022
Acanthamoeba species are among the most ubiquitous protists that are widespread in soil and water and act as both a replicative niche and vectors for dispersal. They are the most important human intracellular pathogens, causing Acanthamoeba keratitis (AK)
Xiaobin Gu, Xiuhai Lu, Shudan Lin, Xinrui Shi, Yue Shen, Qingsong Lu, Yiying Yang, Jing Yang, Jiabei Cai, Chunyan Fu, Yongliang Lou, Meiqin Zheng   +11 more
doaj   +1 more source