Results 11 to 20 of about 735,742 (300)
, 2020 This Element presents a philosophical exploration of the concept of the 'model organism' in contemporary biology. Thinking about model organisms enables us to examine how living organisms have been brought into the laboratory and used to gain a better understanding of biology, and to explore the research practices, commitments, and norms underlying ...
Ankeny, R.A., Leonelli, S.
core +6 more sources
Handbook of Marine Model Organisms in Experimental Biology [PDF]
, 2021 The importance of molecular approaches for comparative biology and the rapid development of new molecular tools is unprecedented. The extraordinary molecular progress belies the need for understanding the development and basic biology of whole organisms.
core +5 more sources
Diversifying the concept of model organisms in the age of -omics. [PDF]
Commun Biol, 2023 International audienceAbstract In today’s post-genomic era, it is crucial to rethink the concept of model organisms. While a few historically well-established organisms, e.g. laboratory rodents, have enabled significant scientific breakthroughs, there is
Bertile F +4 more
europepmc +2 more sources
Harnessing the Power of Model Organisms To Unravel Microbial Functions in the Coral Holobiont
, 2022 Stony corals build the framework of coral reefs, ecosystems of immense ecological and economic importance. The existence of these ecosystems is threatened by climate change and other anthropogenic stressors that manifest in microbial dysbiosis such as ...
Michael Sweet +13 more
core +1 more source
Model Organisms to Study Autophagy. [PDF]
Cells, 2023 Autophagy is the major lysosomal pathway for the clearance of proteins, organelles and microbes in eukaryotic cells. Therefore, autophagic dysfunction can lead to numerous human diseases, like cancer or neurodegeneration, and may facilitate infections by
Xiong Q, Eichinger L.
europepmc +2 more sources
Scientific Reports, 2023 Both PD1/PD-L1 and CD47 blockades have demonstrated limited activity in most subtypes of NHL save NK/T-cell lymphoma. The hemotoxicity with anti-CD47 agents in the clinic has been speculated to account for their limitations. Herein we describe a first-in-
Hang Ke +15 more
doaj +1 more source
Cell Death and Disease, 2021 Adhesion G protein-coupled receptor A1 (ADGRA1, also known as GPR123) belongs to the G protein-coupled receptors (GPCRs) family and is well conserved in the vertebrate lineage.
Xiao-Hong Zhang +12 more
doaj +1 more source
Studying placebo effects in model organisms will help us understand them in humans [PDF]
, 2017 The placebo effect is widely recognized but important questions remain, for example whether the capacity to respond to a placebo is an evolved, and potentially ubiquitous trait, or an unpredictable side effect of another evolved process.
Simon C. Harvey +3 more
core +1 more source
Modeling versatility as the hallmark of model organisms. [PDF]
Hist Philos Life SciIn recent years, discussions on the epistemology of model organism-based research have emerged in the philosophy of science. A key topic of discussion is how the epistemic insights from model organisms differ from those gained through other experimental ...
Prieto GI, Fábregas-Tejeda A.
europepmc +2 more sources
Yeast as a Model Organism [PDF]
Science, 1997 Yeast have many genes with homologs in humans. Has our understanding of these genes helped our understanding of human biology or disease? In his Perspective, Botstein argues "yes" and, as an example, discusses a report in this week9s issue by Sinclair et al.
D, Botstein, S A, Chervitz, J M, Cherry
openaire +2 more sources