Results 11 to 20 of about 1,433,700 (300)

A novel multimeric sCD19‐streptavidin fusion protein for functional detection and selective expansion of CD19‐targeted CAR‐T cells

open access: yesCancer Medicine, 2022
Background CARs are engineered receptors comprising an immunoglobulin single‐chain variable fragment (scFv) that identifies and binds to the target antigen, a transmembrane domain, and an intracellular T‐cell signaling domain.
Hui Lian   +10 more
doaj   +1 more source

HX009, a novel BsAb dual targeting PD1 x CD47, demonstrates potent anti-lymphoma activity in preclinical models

open access: yesScientific Reports, 2023
Both PD1/PD-L1 and CD47 blockades have demonstrated limited activity in most subtypes of NHL save NK/T-cell lymphoma. The hemotoxicity with anti-CD47 agents in the clinic has been speculated to account for their limitations. Herein we describe a first-in-
Hang Ke   +15 more
doaj   +1 more source

A porous prolate-spheroidal model for ciliated micro-organisms [PDF]

open access: yes, 1977
A fluid-mechanical model is developed for representing the mechanism of propulsion of a finite ciliated micro-organism having a prolate-spheroidal shape.
Keller, Stuart R., Wu, Theodore Y.
core   +1 more source

ADGRA1 negatively regulates energy expenditure and thermogenesis through both sympathetic nervous system and hypothalamus–pituitary–thyroid axis in male mice

open access: yesCell Death and Disease, 2021
Adhesion G protein-coupled receptor A1 (ADGRA1, also known as GPR123) belongs to the G protein-coupled receptors (GPCRs) family and is well conserved in the vertebrate lineage.
Xiao-Hong Zhang   +12 more
doaj   +1 more source

Brown Algal Model Organisms [PDF]

open access: yesAnnual Review of Genetics, 2020
Model organisms are extensively used in research as accessible and convenient systems for studying a particular area or question in biology. Traditionally, only a limited number of organisms have been studied in detail, but modern genomic tools are enabling researchers to extend beyond the set of classical model organisms to include novel species from
Coelho, Susana M., Cock, J. Mark
openaire   +4 more sources

Multiple phase transitions in an agent-based evolutionary model with neutral fitness [PDF]

open access: yes, 2017
Null models are crucial for understanding evolutionary processes such as speciation and adaptive radiation. We analyse an agent-based null model, considering a case without selection—neutral evolution—in which organisms are defined only by phenotype ...
Bahar, Sonya   +2 more
core   +2 more sources

Improvement of Detection Method of Pasteurella pneumotropica and Its Medical Elimination in Mice

open access: yesShiyan dongwu yu bijiao yixue, 2021
ObjectiveTo modify the method for sensitive detection of Pasteurella pneumotropica in mice in routine monitoring, and to explore the feasibility of medical elimination in Pasteurella pneumotropica infected mice.MethodsThe Pasteurella pneumotropica were ...
ZHANG Tao   +3 more
doaj   +1 more source

Circulating Mucosal-Associated Invariant T Cells in a Large Cohort of Healthy Chinese Individuals From Newborn to Elderly

open access: yesFrontiers in Immunology, 2019
Mucosal-associated invariant T (MAIT) cells, which are enriched in human blood and express a semi-invariant TCR chain, play important roles in conditions such as infectious diseases and cancer.
Pengcheng Chen   +19 more
doaj   +1 more source

Protein import into the endosymbiotic organelles of apicomplexan parasites [PDF]

open access: yes, 2018
The organelles of endosymbiotic origin, plastids, and mitochondria, evolved through the serial acquisition of endosymbionts by a host cell. These events were accompanied by gene transfer from the symbionts to the host, resulting in most of the organellar
Fellows, Justin   +3 more
core   +1 more source

ATG7 Overexpression Is Crucial for Tumorigenic Growth of Bladder Cancer In Vitro and In Vivo by Targeting the ETS2/miRNA196b/FOXO1/p27 Axis

open access: yesMolecular Therapy: Nucleic Acids, 2017
Human bladder cancer (BC) is the fourth most common cancer in the United States. Investigation of the strategies aiming to elucidate the tumor growth and metastatic pathways in BC is critical for the management of this disease.
Junlan Zhu   +11 more
doaj   +1 more source

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