Results 31 to 40 of about 1,433,700 (300)

Metabolic network modeling with model organisms [PDF]

Current Opinion in Chemical Biology, 2017
Flux balance analysis (FBA) with genome-scale metabolic network models (GSMNM) allows systems level predictions of metabolism in a variety of organisms. Different types of predictions with different accuracy levels can be made depending on the applied experimental constraints ranging from measurement of exchange fluxes to the integration of gene ...
Yilmaz, L. Safak, Walhout, Albertha J M
openaire   +3 more sources

A Model of Discovery: The Role of Imaging Established and Emerging Non-mammalian Models in Neuroscience

Frontiers in Molecular Neuroscience, 2022
Rodents have been the dominant animal models in neurobiology and neurological disease research over the past 60 years. The prevalent use of rats and mice in neuroscience research has been driven by several key attributes including their organ physiology ...
Elizabeth M. Haynes, Elizabeth M. Haynes, Tyler K. Ulland, Kevin W. Eliceiri, Kevin W. Eliceiri, Kevin W. Eliceiri, Kevin W. Eliceiri   +6 more
doaj   +1 more source

Metabolomic Studies for the Evaluation of Toxicity Induced by Environmental Toxicants on Model Organisms

Metabolites, 2021
Environmental pollution causes significant toxicity to ecosystems. Thus, acquiring a deeper understanding of the concentration of environmental pollutants in ecosystems and, clarifying their potential toxicities is of great significance.
Hyung Min Kim, Jong Seong Kang
doaj   +1 more source

Opportunities for organoids as new models of aging. [PDF]

, 2018
The biology of aging is challenging to study, particularly in humans. As a result, model organisms are used to approximate the physiological context of aging in humans. However, the best model organisms remain expensive and time-consuming to use.
Antonica, Arora, Astashkina, Auger, Aw, Azpurua, Barbero, Barkauskas, Barkauskas, Barker, Bartfeld, Behjati, Belmin, Ben-Ze’ev, Bhumiratana, Blau, Blokzijl, Brack, Broutier, Busuttil, Caron, Caughey, Cerchiari, Chambers, Chang, Chaudhuri, Choi, Cornacchia, Crabb, Danahay, Dekkers, Dos Santos, Dye, Eiraku, Elahy, Engevik, Freedman, Gao, Garbe, Gjorevski, Greider, Gullapalli, Hannum, Hansen, Hegab, Heintz, Hibiya, Hohwieler, Horvath, Htwe, Huch, Huch, Jennifer L. Hu, Jones, Jung, Karthaus, Kolesky, Koo, Kwong, Lang, Lee, Lee, Levental, Li, Li, Lindahl, Linnemann, Liu, Lozito, Lyons, López-Otín, L’Heureux, Madden, Marciniak, Mark A. LaBarge, Matsui, Mattison, McElwee, Meerwaldt, Mertens, Messner, Michael E. Todhunter, Miller, Moore, Moore, Morizane, Murrow, Myers, Nalapareddy, Nasto, Nelson, Nevalainen, Nguyen-Ngoc, Nicholas, Noguchi, Ootani, O’Brien, Pageon, Pang, Parrinello, Pauli, Phillip, Plaks, Pribluda, Qian, Raja, Rangarajan, Rodriguez-Teja, Ruan, Sancar, Sato, Schütte, Seok, Simian, Singh, Squires, Stampfer, Stearns-Reider, Stojadinovic, Sun, Takasato, Takebe, Tan, Tanos, Toda, Todhunter, Turco, Tzatzalos, van Vliet, Vanhooren, Vernetti, Verzijl, Villadsen, Villeda, Voytik-Harbin, Watson, Williams, Wilson, Workman, Wu, Wylie, Xiang, Yilmaz, Zev J. Gartner, Zhang, Zhang   +145 more
core   +2 more sources

γ-Aminobutyric Acid Transporter Mutation GAT1 (S295L) Substantially Impairs Neurogenesis in Dentate Gyrus

Brain Sciences
Background: GABAergic signaling plays a crucial role in modulating neuronal proliferation, migration, and the formation of neural network connections. The termination of GABA transmission primarily occurs through the action of GABA transporter 1 (GAT1 ...
Weitong Liu, Yantian Yang, Yichen Liu, Bingyan Ni, Hua Zhuang, Kexin Chen, Jiahao Shi, Chenxin Zhu, Haoyue Wang, Jian Fei   +9 more
doaj   +1 more source

Cell division and migration in a 'genotype' for neural networks [PDF]

, 1994
Much research has been dedicated recently to applying genetic algorithms to populations of neural networks. However, while in real organisms the inherited genotype maps in complex ways into the resulting phenotype, in most of this research the ...
Cangelosi, Angelo, Nolfi, Stefano, Parisi, Domenico   +2 more
core   +2 more sources

Development of a Sensitive Escherichia coli Bioreporter Without Antibiotic Markers for Detecting Bioavailable Copper in Water Environments

Frontiers in Microbiology, 2020
The whole-cell bioreporters based on the cop-operon sensing elements have been proven specifically useful in the assessment of bioavailable copper ions in water environments.
Yilin Pang, Yilin Pang, Xiaojun Ren, Jianghui Li, Feng Liang, Xiaoyu Rao, Yang Gao, Wenhe Wu, Dong Li, Juanjuan Wang, Jianguo Zhao, Xufen Hong, Fengying Jiang, Wu Wang, Huaibin Zhou, Jianxin Lyu, Jianxin Lyu, Guoqiang Tan   +17 more
doaj   +1 more source

Different syngeneic tumors show distinctive intrinsic tumor-immunity and mechanisms of actions (MOA) of anti-PD-1 treatment

Scientific Reports, 2022
Cancers are immunologically heterogeneous. A range of immunotherapies target abnormal tumor immunity via different mechanisms of actions (MOAs), particularly various tumor-infiltrate leukocytes (TILs).
Ying Jin, Xiaoyu An, Binchen Mao, Ruilin Sun, Rajendra Kumari, Xiaobo Chen, Yongli Shan, Mingfa Zang, Ling Xu, Jan Muntel, Kristina Beeler, Roland Bruderer, Lukas Reiter, Sheng Guo, Demin Zhou, Qi-Xiang Li, Xuesong Ouyang   +16 more
doaj   +1 more source

Robust Multi-Cellular Developmental Design [PDF]

, 2007
This paper introduces a continuous model for Multi-cellular Developmental Design. The cells are fixed on a 2D grid and exchange "chemicals" with their neighbors during the growth process.
Bredèche, Nicolas, Devert, Alexandre, Schoenauer, Marc   +2 more
core   +5 more sources

Genome organization: experiments and modeling [PDF]

Chromosome Research, 2017
7 pages, 1 ...
Gilbert, Nick, Marenduzzo, Davide
openaire   +4 more sources