Results 21 to 30 of about 193,735,207 (244)

Optimization of Car Use Time for Different Maintenance and Repair Scenarios Based on Life Cycle Assessment

Applied Sciences, 2023
New propulsion technologies and the development of electromobility increase the environmental efficiency of the transport sector. However, the current structure of car fleets with a large number of old cars with worse environmental parameters undermines ...
Krzysztof Danilecki, Piotr Smurawski, Kamil Urbanowicz   +2 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

RISK MODELLING OF HEAVY MOBILE EQUIPMENT TO DETERMINE OPTIMUM REPLACEMENT AGES

South African Journal of Industrial Engineering, 2017
Maintenance and physical asset managers often have to decide when a major asset needs to be replaced. The main objective of this study was to develop a methodology to determine the optimum replacement age of heavy mobile equipment that is close to the ...
Carl Kirstein, Jacobus Krige Visser
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Femoral stem wear in cemented total hip replacement [PDF]

, 2008
The great success of cemented total hip replacement to treat patients with end-stage osteoarthritis and osteonecrosis has been well documented. However, its long-term survivorship has been compromised by progressive development of aseptic loosening, and ...
Barrans, Simon, X-Q Jiang, Zhang, H. Y., Blunt, Liam, Jiang, Xiang, S Barrans, Zhao, Y., L Brown, Jiang, X. Q., Y Zhao, Blunt, L., L Blunt, Barrans, S., Zhang, Hongyu, H-Y Zhang, Brown, Leigh, Brown, L.; id_orcid   +16 more
core   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

7-Valent pneumococcal conjugate vaccination in England and Wales: is it still beneficial despite high levels of serotype replacement? [PDF]

, 2011
BACKGROUND: The UK introduced the 7-valent pneumococcal conjugate vaccine (PCV7) into the national vaccination program in September 2006. Previous modelling assumed that the likely impact of PCV7 on invasive pneumococcal disease (IPD) would be similar to
Nigel Gay, Andrews, Nick, George, Robert, Robert George, Gay Nigel, Miller, Elizabeth, George Robert, Pauline A Waight, Miller Elizabeth, Yoon Hong Choi, N. Gay, Choi, Yoon Hong, Pauline A. Waight, Andrews Nick, R. George, Nick Andrews, Waight Pauline A., Jit, Mark, Gay, Nigel, Jit Mark, Y.H. Choi, Choi Yoon Hong, Elizabeth Miller, M. Jit, P.A. Waight, Melegaro, Alessia, E. Miller, Mark Jit, N. Andrews, Waight, Pauline A, Melegaro Alessia, Alessia Melegaro   +31 more
core   +1 more source