Results 81 to 90 of about 166,012,390 (296)

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Intelligent identification and warning method of disc cutter abnormal wear in TBM construction based on extreme learning machine

Scientific Reports
Abnormal cutter wear has a serious impact on TBM construction. If not found in time, it may lead to the cutterhead overall failure. Aiming at this problem, a general model and method to identify and warn the abnormal cutter wear using Extreme Learning ...
Qingwei Li, Lijie Du, Yalei Yang, Zhihua Ni, Xiangbo Zhao   +4 more
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Impacts of Strike Replacement Bans in Canada [PDF]

In the labor relations area no issue generates as much controversy and division between labor and management as does the legislative ban on replacement workers.
Peter Cramton, Morley Gunderson, Joseph Tracy   +2 more
core  

Modelling cost-effectiveness of replacement strategies for ambulance services in the Ministry of Health Malaysia

BMC Health Services Research
Background Emergency Medical Service (EMS) is a very crucial aspect of the healthcare system in providing urgent management and transportation of patients during emergencies.
Nor Zam Azihan Mohd Hassan, Mohd Shahri Bahari, Sivaraj Raman, Farhana Aminuddin, Mohd Shaiful Jefri Mohd Nor Sham Kunusagaran, Nur Amalina Zaimi, Min Fui Wong, Marhaini Mostapha, Ahmad Tajuddin Mohamad Nor, Mohd Ridzwan Shahari   +9 more
doaj   +1 more source

Image inpainting enhancement by replacing the original mask with a self-attended region from the input image

CoRR
Image inpainting, the process of restoring missing or corrupted regions of an image by reconstructing pixel information, has recently seen considerable advancements through deep learning-based approaches. In this paper, we introduce a novel deep learning-based pre-processing methodology for image inpainting utilizing the Vision Transformer (ViT).
Kiani, Kourosh, Rastgoo, Razieh, Chaji, Alireza, Escalera, Sergio   +3 more
openaire   +3 more sources

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Technological breakthroughs and asset replacement [PDF]

The authors analyze the optimal replacement of assets under continuous and discontinuous technological change. They investigate the variable lifetime of assets in an infinite-horizon replacement problem.
Yatsenko, Yuri, Hritonenko, Natali
core  

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source