Results 71 to 80 of about 166,012,390 (296)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Discrete-continuous analysis of optimal equipment replacement [PDF]

In Operations Research, the equipment replacement process is usually modeled in discrete time. The optimal replacement strategies are found from discrete (or integer) programming problems, well known for their analytic and computational complexity.
YATSENKO, Yuri, HRITONENKO, Natali
core  

A simple method for estimating inter-generational replacement based on fertility and migration European examples

, 2010
Concern over unprecedentedly low levels of childbearing in Europe has become increasingly marked among both scientists and policy-makers. In conjunction with these concerns over fertility, there has also been considerable debate on the role migration can
Wilson, Chris, Wilson, Christopher Cleveland Boag, Sobotka, Tomas, Williamson, Lee, Boyle, Paul, Boyle, Paul Joseph   +5 more
core   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Introducing AI in Pension Planning: A Comparative Study of Deep Learning and Mamdani Fuzzy Inference Systems for Estimating Replacement Rates

Mathematics
Funded pensions have become a key focus in strategies to ensure supplementary income during retirement. This paper explores two distinct approaches for estimating replacement rates: a deep learning model and a Mamdani Fuzzy Inference System (FIS).
Pantelis Z. Lappas, Georgios Symeonidis
doaj   +1 more source

Excitatory, inhibitory and structural plasticity produce correlated connectivity in random networks trained to solve paired-stimulus tasks

Frontiers in Computational Neuroscience, 2011
The pattern of connections among cortical excitatory cells with overlapping arbors is non-random. In particular, correlations among connections produce clustering – cells in cliques connect to each other with high probability, but with lower probability ...
Mark A Bourjaily, Paul Miller
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Open Cow Replacement Decisions: an Application of Asset Replacement Theory [PDF]

Beef producers must decide what to do with a cow that fails to conceive during the breeding season. Keeping the open cow results in a years expenses without any revenue.
Anderson, John D., Ibendahl, Gregory A.
core  

From static archetypes toward dynamic, condition-aware archetypes in UBEM: an integrative review with an illustrative case demonstration

Frontiers in Energy Research
Urban Building Energy Modeling (UBEM) is often used for large-scale renovation planning. However, UBEM traditionally uses static archetypes, which fail to reflect the current state of buildings, particularly in partially renovated stocks.
Fariha Harun, Ergo Pikas, Elisa Iliste, Jaanus Hallik, Targo Kalamees   +4 more
doaj   +1 more source