Results 51 to 60 of about 166,012,390 (296)

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

hESC-Derived Dopaminergic Transplants Integrate into Basal Ganglia Circuitry in a Preclinical Model of Parkinson’s Disease

Cell Reports, 2019
Summary: Cell replacement is currently being explored as a therapeutic approach for neurodegenerative disease. Using stem cells as a source, transplantable progenitors can now be generated under conditions compliant with clinical application in patients.
Andrew F. Adler, Tiago Cardoso, Sara Nolbrant, Bengt Mattsson, Deirdre B. Hoban, Ulla Jarl, Jenny Nelander Wahlestedt, Shane Grealish, Anders Björklund, Malin Parmar   +9 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Boosting the Transferability of Adversarial Attacks with Semantic-Invariance and Low-Gradient Replacement

Mathematics
Deepneural networks are highly vulnerable to adversarial examples, which are generated by introducing subtle perturbations to input data to mislead model classification.
Yunqi Zhang, Wei Chen, Lei Zhao, Liwen Wu, Tong Su   +4 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Gaussian Process priors with uncertain inputs? Application to multiple-step ahead time series forecasting [PDF]

, 2003
We consider the problem of multi-step ahead prediction in time series analysis using the non-parametric Gaussian process model. k-step ahead forecasting of a discrete-time non-linear dynamic system can be performed by doing repeated one-step ahead ...
Quiñonero Candela, J, Rasmussen, C., ,, Murray-Smith, Roderick, Rasmussen, C.E., Quinonero-Candela, J., Rasmussen, Carl Edward, Quiñonero-Candela, Joaquin, Girard, A., Rasmussen, CE, Murray-Smith, R., Girard, A, Girard, Agathe, Murray Smith, R   +13 more
core   +5 more sources

Entecavir: stability and drug-excipient compatibility [PDF]

Brazilian Journal of Pharmaceutical Sciences
Entecavir is an inhibitor of hepatitis B virus (HBV) DNA synthesis that has been widely prescribed in the treatment of chronic infections caused by the virus. Production of generic ETV drugs is an ongoing global endeavor, with particular significance for
Ariadne Botto Fiorot, Clayton Raynan dos Santos, Thiago Padovani Xavier, Taisa Shimosakai de Lira, Marcelo Antonio de Oliveira   +4 more
doaj   +1 more source

Headphones over the cochlear-implant sound processor to replace direct audio input

JASA Express Letters
Psychoacoustic stimulus presentation to the cochlear implant via direct audio input (DAI) is no longer possible for many newer sound processors (SPs). This study assessed the feasibility of placing circumaural headphones over the SP. Calibration spectra for loudspeaker, DAI, and headphone modalities were estimated by measuring cochlear-implant ...
Joshua G W, Bernstein, Julianna, Voelker, Sandeep A, Phatak   +2 more
openaire   +2 more sources

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source