Results 121 to 130 of about 571,216 (355)

KCNJ2 is Required for NLRP3 Inflammasome Activation That Drives Allergic Airway Inflammation and Remodeling

Advanced Science, EarlyView.
This study aims to evaluate the impact of the potassium channel KCNJ2 on asthma development. KCNJ2 promotes NLRP3 inflammasome activation through both Ca2+ influx and K+ efflux in airway epithelial cells, which drives allergic airway inflammation and remodeling, suggesting a promising therapeutic target for asthma.
Yachao Cui, Shumei Wu, Yang Peng, Yiqi Liu, Li Che, Shiying Chen, Feng Zhang, Dajiang Qin, Shiyue Li, Pixin Ran, Wenguang Yin   +10 more
wiley   +1 more source

The Effect of Collective Bargaining Legislation on Strikes and Wages [PDF]

Using Canadian data on large, private-sector contract negotiations from January 1967 to March 1993, we find that strikes and wages are substantially influenced by labor policy. The data indicate that conciliation policies have largely been ineffective in
Joseph Tracy, Morley Gunderson, Peter Cramton   +2 more
core  

Inventory management in railway sleepers: A simulation model for replacement strategies [PDF]

, 2000
This paper describes the development of a simulation model to assess the inventory requirements of alternative rail sleeper replacement strategies. The main aim of the model is to determine the optimal replacement strategy, given replacement costs and ...
Ferreira, Luis, Yun, Won Young
core   +1 more source

TEMPORARY REMOVAL: Corrigendum to ‘Implications of Vitamin D Research in Chickens can Advance Human Nutrition and Perspectives for the Future’ [Current Developments in Nutrition Volume 5 (2021) nzab018]

Current Developments in Nutrition
The publisher regrets that this article has been temporarily removed. A replacement will appear as soon as possible in which the reason for the removal of the article will be specified, or the article will be reinstated.The full Elsevier Policy on ...
Matthew F Warren
doaj   +1 more source

Discovery of an Adaptive Neuroimmune Response Driving Itch and Fast Tick Removal with Implications for Preventing Pathogen Transmission

Advanced Science, EarlyView.
Itch‐induced tick removal (IITR): An acquired neuroimmune mechanism, itch‐induced tick removal, develops after repeated tick exposure, mobilizing T cells and macrophages at the tick bite site to trigger a rapid scratching response that facilitates timely tick removal within a critical window that precedes the transmission of many tick‐borne pathogens ...
Johannes S. P. Doehl, Tiago D. Serafim, Serena Doh, Charles S. Grugan, Eva Iniguez, Luana Rogerio, Ronja Frigard, Ranadhir Dey, Pedro Cecilio, Xinglong Gu, Pang‐Yen Tseng, Aline da Silva Moreira, Mahnaz Minai, James Oristian, Hans Ackerman, Steven Brooks, Caroline Percopo, Siu‐Ping Ng, Derron A. Alves, Lucas Tirloni, Jennifer M. Anderson, Adriana Marques, Fabiano Oliveira, Shaden Kamhawi, Daniel E. Sonenshine, José M. C. Ribeiro, Mark Hoon, Jesus G. Valenzuela   +27 more
wiley   +1 more source

End-of-Life Inventory Decisions for Consumer Electronics Service Parts [PDF]

We consider a consumer electronics (CE) manufacturer’s problem of controlling the inventoryof spare parts in the final phase of the service life cycle.
Dekker, R., Frenk, J.B.G., Pourakbar, M.
core   +1 more source

Potent and Selective IGF‐IIR‐Recruiting Bifunctional Molecules for Targeted Lysosomal Degradation of Extracellular and Membrane Proteins

Advanced Science, EarlyView.
Lysosome‐targeting chimeras (LYTACs) enable degradation of extracellular and membrane proteins via lysosomal trafficking. We report a novel IGF‐II mutant (Del1–7, Y27L) that selectively engages IGF‐IIR while avoiding IGF‐IR and IR‐A. mutIGF‐II–based LYTACs enhance target internalization and degradation and support a genetically encodable, all‐protein ...
Yuan Zhao, Yaxian Liao, Pengyun Li, Regina Stasser de Gonzalez, Xuankun Chen, Nicholas S. Nieto, Florence M. Brunel, Nick Cox, Joseph Stock, Matthew McHenry, Guangsen Fu, Penghsuan Huang, Wenxin Wu, Deqin Cai, Lingjun Li, Alexander N. Zaykov, Weiping Tang   +16 more
wiley   +1 more source

US and EU Trade Policies and East Asia [PDF]

This article identifies a number of examples of apparent lack of coherence in United States and European Union trade policies. They include the effect of preferential policies that lock in trade shares and inhibit growth promoting structural adjustment ...
Christopher Findlay, Peter Drysdale
core   +4 more sources

Supplementary Role of Health Metrics for Reducing Total Fertility Rate in a North-Indian State. [PDF]

, 2013
Reducing Total Fertility Rate (TFR) amongst rural Indian couples from the current level is a significant challenge to the population control policies relying solely on the Government efforts. REACH strategy, based on health metrics, succeeded in lowering
Ganguly, E
core   +1 more source

Vehicle scrappage policies for transportation decarbonization

Environmental Research: Energy
Vehicle electrification is one of the primary strategies being pursued for the decarbonization of the transportation sector. But to meet emissions reduction goals for that sector, the current vehicle replacement rate is insufficient.
Maxwell Woody, Samuel Stolper, Parth Vaishnav, Gregory A Keoleian   +3 more
doaj   +1 more source