Results 91 to 100 of about 3,519,757 (299)

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Quality of compensation and well-being of patients with primary hypothyroidism and obesity

Клиническая и экспериментальная тиреоидология, 2016
Aim. The aim of the study was to compare quality of hypothyroidism compensation and well-being of patients with hypothyroidism with normal weight, overweight and obesity. Methods.
Valentin V. Fadeyev, Tatyana Borisovna Morgunova, Yulia Aleksandrovna Manuylova, Meruert S. Madiyarova   +3 more
doaj   +1 more source

Transcatheter aortic-valve replacement for inoperable severe aortic stenosis. [PDF]

, 2012
BACKGROUND: Transcatheter aortic-valve replacement (TAVR) is the recommended therapy for patients with severe aortic stenosis who are not suitable candidates for surgery. The outcomes beyond 1 year in such patients are not known.
Makkar, Raj R, Dewey, Todd M, Pocock, Stuart, Brown, David L, Pichard, Augusto D, Bowers, Bruce, Siegel, Robert J, Smith, Craig R, Webb, John G, Tuzcu, Murat, Moses, Jeffrey W, Williams, Matthew R, Babaliaros, Vasilis C, Thourani, Vinod H, Kapadia, Samir, Svensson, Lars G, Jilaihawi, Hasan, Kodali, Susheel, Bavaria, Joseph E, MD, Fontana, Gregory P, Akin, Jodi J, Douglas, Pamela S, Bavaria, Joseph E, Herrmann, Howard C, Leon, Martin B, PARTNER Trial Investigators, Anderson, William N   +26 more
core   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

A Rare Clinical Association of Type I Hereditary Angioedema and Acquired Epidermolysis Bullosa: A Case Report

Galician Medical Journal
Introduction. Both hereditary angioedema (HAE) and acquired epidermolysis bullosa (AEB) are extremely rare disorders, and their coexistence in a single patient is unique.
Tetiana Sviatenko, Yulia Dieieva, Inna Gogunska, Liudmyla Zabrodska, Serhii Zakharov, Olga Naumova   +5 more
doaj   +1 more source

Psychological well-being on thyroid hormone replacement [PDF]

Despite 100 years after the discovery of thyroxine, controversy still exists regarding optimal thyroid hormone replacement therapy. Several anecdotal reports suggest that thyroxine alone therapy does not normalise psychological wellbeing.
Saravanan, Ponnusamy
core  

Study protocol for a non-inferiority trial of cytisine versus nicotine replacement therapy in people motivated to stop smoking [PDF]

, 2011
Background Smokers need effective support to maximise the chances of successful quit attempts. Current smoking cessation medications, such as nicotine replacement therapy (NRT), bupropion, nortriptyline or varenicline, have been shown to be effective in ...
Hayden McRobbie, Nosa, V, Walker, N, Glover, M, Howe Colin, Joanne Barnes, Bullen, C, Glover Marewa, McRobbie Hayden, Jonathan Williman, McRobbie, H, Barnes, J, Howe, C, Walker Natalie, Colin Howe, Williman, J, Bullen Chris, Reon Veale, Varsha Parag, Natalie Walker, Parag Varsha, Veale Reon, Marewa Glover, Vili Nosa, Veale, R, Parag, V, Williman Jonathan, Nosa Vili, Chris Bullen, Barnes Joanne   +29 more
core   +2 more sources

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Treatments in oral lichen planus: a review

Frontiers in Oral Health
Oral lichen planus is a chronic inflammatory disease of the oral mucosa characterized by pain and burning sensation. The etiology of OLP is complex and multifactorial, leading to recurrence and a lack of clear treatment methods.
Ce Gou, Ce Gou, Qinghua Zhang, Qinghua Zhang, Zhijun Zhang, Zhijun Zhang   +5 more
doaj   +1 more source

A glance on recent progresses in diagnosis and treatment of primary immunodeficiencies/ Progrese recente în diagnosticul şi tratamentul imunodeficienţelor primare

Romanian Journal of Laboratory Medicine, 2014
Primary immunodeficiencies (PIDs)* belong to the group of rare diseases which need more awareness by the relevant medical disciplines. Below a review on recent progresses in diagnosis and treatment of PIDs is given.
Späth Peter J.
doaj   +1 more source