Results 71 to 80 of about 20,760 (271)
Modulation of gene expression in endothelial cells in response to high LET nickel ion irradiation [PDF]
, 2014 Ionizing radiation can elicit harmful effects on the cardiovascular system at high doses. Endothelial cells are critical targets in radiation-induced cardiovascular damage.
Aerts, An +15 more
core +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Development of improved electroforming technique [PDF]
Techniques were studied to reinforce or strengthen electroformed nickel to allow a fuller utilization of electroforming as a reliable and low cost fabrication technique for regenerately cooled thrust chambers.
Davies, L. G., Mccandles, L. C.
core +1 more source
Pathways of genetic adaptation: multistep origin of mutants under selection without induced mutagenesis in Salmonella enterica. [PDF]
, 2012 In several bacterial systems, mutant cell populations plated on growth-restricting medium give rise to revertant colonies that accumulate over several days.
Quiñones-Soto, Semarhy +2 more
core
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Assessing Antibiotic Tolerance of Staphylococcus aureus Derived Directly from Patients by the Replica Plating Tolerance Isolation System (REPTIS). [PDF]
Antimicrob Agents Chemother, 2022 Herren SC +9 more
europepmc +1 more source
Rapid Replication of High Aspect Ratio Molds for UV Embossing [PDF]
, 2003 This paper describes a promising fabrication technique for rapid replication of high aspect ratio microstructured molds for UV embossing. The process involves casting silicone rubber on a microstructured master, replicating an epoxy mold using the PDMS ...
Chan-Park, Mary Bee-Eng +2 more
core
Inflating bacterial cells by increased protein synthesis. [PDF]
, 2015 Understanding how the homeostasis of cellular size and composition is accomplished by different organisms is an outstanding challenge in biology. For exponentially growing Escherichia coli cells, it is long known that the size of cells exhibits a strong ...
Basan, Markus +6 more
core +2 more sources
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source