Results 201 to 210 of about 30,672 (266)

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source

Evaluation of the replicability of systematic reviews with meta-analyses of the effects of health interventions. [PDF]

Res Synth Methods
Hamilton DG, McKenzie JE, Nguyen PY, Rethlefsen ML, McDonald S, Brennan SE, Fidler FM, Higgins JPT, Kanukula R, Karunananthan S, Maxwell LJ, Moher D, Nakagawa S, Nunan D, Tugwell P, Welch VA, Page MJ.   +16 more
europepmc   +1 more source

A submission checklist to improve transparency and replicability of functional genomics data analyses. [PDF]

J Biol Chem
Hepperla AJ, Hardison RC, Colbran RJ, Strahl BD, Simon JM.   +4 more
europepmc   +1 more source

Exploring electroencephalographic chronic pain biomarkers: a mega-analysis. [PDF]

EBioMedicine
Bott FS, Zebhauser PT, Hohn VD, Turgut Ö, May ES, Tiemann L, Gil Ávila C, Heitmann H, Nickel MM, Day MA, Adhia DB, Ashar YK, Wager TD, Granovsky Y, Yarnitsky D, Jensen MP, Gross J, Ploner M.   +17 more
europepmc   +1 more source

Dog brain atlas generated via spatially constrained spectral clustering

Hernández-Pérez R, Cuaya LV, Boch M, Barrios FA, Alcauter S, Huber L, Lamm C.   +6 more
europepmc   +1 more source