Results 101 to 110 of about 7,284,411 (284)

Acceptability, feasibility, and program outcomes of an equity-focused, adapted community-based healthy lifestyle program for children, young people, and their families in Perth, Western Australia: an implementation hybrid research protocol

Frontiers in Health Services
BackgroundInternational guidelines recommend multidisciplinary intervention programs for addressing childhood obesity. In Western Australia, community-based healthy lifestyle programs for children and young people are insufficient for demand, especially ...
Stephanie Smith, Stephanie Smith, Stephanie Smith, Stephen Paull, Stephen Paull, Stephen Paull, Katie M. Iwanowski, Katie M. Iwanowski, Katie M. Iwanowski, Tania Harris, Joanna C. Moullin, Monica Jane, Jordan Bill, Deborah A. Kerr, Christina M. Pollard, Glenn Pearson, Melanie Robinson, Bonnie Furzer, Bonnie Furzer, Bonnie Furzer, Natasha Bear, Ben Jackson, Ben Jackson, Robyn Mildon, Nick Sevdalis, Richard Norman, Jacqueline A. Curran, Jacqueline A. Curran, Cameron C. Grant, Sarah C. Armstrong, Sarah C. Armstrong, Yvonne C. Anderson, Yvonne C. Anderson, Yvonne C. Anderson, Yvonne C. Anderson   +34 more
doaj   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Contextualization of psychological treatments for government health systems in low-resource settings: group interpersonal psychotherapy for caregivers of children with nodding syndrome in Uganda

Implementation Science, 2018
Background Evidence for the effectiveness of psychological treatments in low- and middle-income countries is increasing. However, there is a lack of systematic approaches to guide implementation in government health systems.
Byamah B. Mutamba, Brandon A. Kohrt, James Okello, Janet Nakigudde, Bernard Opar, Seggane Musisi, William Bazeyo, Joop de Jong   +7 more
doaj   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Beyond the Program: Understanding Mechanisms Through Which Nongovernmental Organizations Advance Equity in Stroke Care

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Health disparities in stroke disproportionately affect marginalized and disadvantaged communities. This review examines the role of nongovernmental organizations (NGOs) in addressing disparities through a mechanism‐focused analytical framework rather ...
Michelle L. A. Nelson
doaj   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

A PSYCHOEDUCATIONAL PROGRAM FOR FAMILY CAREGIVERS OF DEMENTIA PATIENTS: EFFECTS AND REPLICABILITY [PDF]

Innovation in Aging, 2017
C.R. Ferreira, E.J. Barham
openaire   +1 more source

Enhancing reading speed: the reading acceleration effect in Italian adult readers

Frontiers in Psychology
IntroductionEnhancing reading efficiency is of paramount importance in various academic, professional and clinical domains. Previous research, mostly from a single laboratory, has shown that externally imposed time constraints by means of text fading can
Denisa Adina Zamfira, Denisa Adina Zamfira, Giuseppe Di Dona, Martina Battista, Martina Battista, Francesco De Benedetto, Luca Ronconi, Luca Ronconi   +7 more
doaj   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source

Making the Most of to Curb the Diabetes Epidemic: Early Evidence of Success Delivering the Same Intervention to Latinas at Risk for and With Diabetes

Clinical Medicine Insights: Endocrinology and Diabetes
Background/objectives: In the USA, diabetes disproportionately affects Hispanics/Latinx, continuing to contribute to health disparities. To address the diabetes epidemic, separate programs for pre-diabetes and diabetes are promoted nationwide.
Maud Joachim-Célestin, Susanne B Montgomery   +1 more
doaj   +1 more source