Results 81 to 90 of about 16,732 (248)

Acceptability, feasibility, and program outcomes of an equity-focused, adapted community-based healthy lifestyle program for children, young people, and their families in Perth, Western Australia: an implementation hybrid research protocol

Frontiers in Health Services
BackgroundInternational guidelines recommend multidisciplinary intervention programs for addressing childhood obesity. In Western Australia, community-based healthy lifestyle programs for children and young people are insufficient for demand, especially ...
Stephanie Smith, Stephanie Smith, Stephanie Smith, Stephen Paull, Stephen Paull, Stephen Paull, Katie M. Iwanowski, Katie M. Iwanowski, Katie M. Iwanowski, Tania Harris, Joanna C. Moullin, Monica Jane, Jordan Bill, Deborah A. Kerr, Christina M. Pollard, Glenn Pearson, Melanie Robinson, Bonnie Furzer, Bonnie Furzer, Bonnie Furzer, Natasha Bear, Ben Jackson, Ben Jackson, Robyn Mildon, Nick Sevdalis, Richard Norman, Jacqueline A. Curran, Jacqueline A. Curran, Cameron C. Grant, Sarah C. Armstrong, Sarah C. Armstrong, Yvonne C. Anderson, Yvonne C. Anderson, Yvonne C. Anderson, Yvonne C. Anderson   +34 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Contextualization of psychological treatments for government health systems in low-resource settings: group interpersonal psychotherapy for caregivers of children with nodding syndrome in Uganda

Implementation Science, 2018
Background Evidence for the effectiveness of psychological treatments in low- and middle-income countries is increasing. However, there is a lack of systematic approaches to guide implementation in government health systems.
Byamah B. Mutamba, Brandon A. Kohrt, James Okello, Janet Nakigudde, Bernard Opar, Seggane Musisi, William Bazeyo, Joop de Jong   +7 more
doaj   +1 more source

A PSYCHOEDUCATIONAL PROGRAM FOR FAMILY CAREGIVERS OF DEMENTIA PATIENTS: EFFECTS AND REPLICABILITY [PDF]

Innovation in Aging, 2017
C.R. Ferreira, E.J. Barham
openaire   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Beyond the Program: Understanding Mechanisms Through Which Nongovernmental Organizations Advance Equity in Stroke Care

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Health disparities in stroke disproportionately affect marginalized and disadvantaged communities. This review examines the role of nongovernmental organizations (NGOs) in addressing disparities through a mechanism‐focused analytical framework rather ...
Michelle L. A. Nelson
doaj   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Enhancing reading speed: the reading acceleration effect in Italian adult readers

Frontiers in Psychology
IntroductionEnhancing reading efficiency is of paramount importance in various academic, professional and clinical domains. Previous research, mostly from a single laboratory, has shown that externally imposed time constraints by means of text fading can
Denisa Adina Zamfira, Denisa Adina Zamfira, Giuseppe Di Dona, Martina Battista, Martina Battista, Francesco De Benedetto, Luca Ronconi, Luca Ronconi   +7 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Making the Most of to Curb the Diabetes Epidemic: Early Evidence of Success Delivering the Same Intervention to Latinas at Risk for and With Diabetes

Clinical Medicine Insights: Endocrinology and Diabetes
Background/objectives: In the USA, diabetes disproportionately affects Hispanics/Latinx, continuing to contribute to health disparities. To address the diabetes epidemic, separate programs for pre-diabetes and diabetes are promoted nationwide.
Maud Joachim-Célestin, Susanne B Montgomery   +1 more
doaj   +1 more source