Results 81 to 90 of about 7,284,411 (284)

Designing Effective Training Programs for Investigative Interviewers of Children

, 2008
‘Best-practice’ guidelines for conducting investigative interviews with children are well established in the literature, yet few investigative interviewers actually adhere to such guidelines in the field. One of the problems is that little discussion has
Powell, Martine B, Martine B. Powell
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Implementing evidence-based interventions in health care: application of the replicating effective programs framework

, 2016
Background We describe the use of a conceptual framework and implementation protocol to prepare effective health services interventions for implementation in community-based (i.e., non-academic-affiliated) settings.
Kilbourne, Amy M, Pincus, Harold A, Stall, Ronald, Bauer, Mark, Neumann, Mary S   +4 more
core   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

ASM-based Modelling of

, 2008
State Machines (ASM 2004) Matt Webster M.P.Webster@csc.liv.ac.uk Department of Computer Science, University of Liverpool, Liverpool L69 7ZF, UK Abstract.
Self-Replicating Programs Ulcs-, Matt Webster   +1 more
core  

A Replication of “The Effect of the Conservation Reserve Program on Rural Economies: Deriving a Statistical Verdict from a Null Finding” ( American Journal of Agricultural Economics , 2019)

Economics, 2023
Abstract This study replicates the paper “Brown, J. P., Lambert, D. M., & Wojan, T. R. (2019). The effect of the conservation reserve program on rural economies: deriving a statistical verdict from a null finding. American Journal of Agricultural Economics ,
openaire   +3 more sources

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Self-Replicating DNA-Based Nanoassemblies [PDF]

The properties of DNA that make it an effective genetic material also allow it to be ideal for programmed self-assembly. Accordingly, DNA-programmed assembly has been utilized to construct responsive DNA origami and wireframe nanoassemblies, yet the ...
Julianne M. , Gibbs, B. Safeenaz , Alladin-Mustan, Jisu, An, Nahida, Akter, Yuning, Liu   +4 more
core   +2 more sources

TRIO Programs: TRIO Day Magazine

, 2011
Magazine for TRIO Day 2011 -- Upward Bound Wichita Prep -- Talent Search -- Student Support Services -- Office of Disability Services -- Upward Bound Math Science Regional Center -- Ronald E.
Office of Special Programs
core   +1 more source