Results 71 to 80 of about 7,284,411 (284)
Disjunctive ASP with functions: Decidable queries and effective computation [PDF]
, 2010 Querying over disjunctive ASP with functions is a highly undecidable task in general. In this paper we focus on disjunctive logic programs with stratified negation and functions under the stable model semantics (ASPfs).
Alviano, Mario +5 more
core +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Statistical approaches to the evaluation of the impact of vaccination programs : a case study exploring rotavirus vaccination in New South Wales [PDF]
, 2018 University of Technology Sydney. Faculty of Health.Vaccination programs can provide an effective means to control infectious diseases at a population level. Evaluating the impact of these programs after implementation can be complicated by limitations of
Mealing, Nicole
core +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Centre for Effective Services: strategy 2012 – 2014 and beyond [PDF]
, 2012 The Centre for Effective Services (CES) was established in 2008 in the Republic of Ireland, and in 2010 in Northern Ireland. The overall remit of the centre was to provide technical and organisational ‘expertise’ to promote and support the application of
Centre for Effective Services
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Erratum to: A FORTRAN 77 program for sample-size determination in replication attempts when effect size is uncertain [PDF]
Behavior Research Methods, Instruments, & Computers, 1991 A method of sample-size determination for use in attempts to replicate experiments is described. It is appropriate in situations where there is uncertainty about the magnitude of the effect under investigation. The procedure uses information supplied by the original experiment to establish a distribution of probable effect sizes.
openaire +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Evaluation and Microenterprise Programs [PDF]
Microenterprise programs attempt to help poor people start or strengthen small businesses. Funding and political support has grown rapidly. Is microenterprise a good use of scarce development funds?
Mark Schreiner
core
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Replicating Microfinance in the United States: Opportunities and Challenges [PDF]
In developing countries, microfinance has been the darling of the development community, and in developed countries, microfinance fits well with Third Ways ideas.
Jonathan Morduch, Mark Schreiner
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