Results 51 to 60 of about 16,732 (248)

A cluster-randomized controlled trial of the effectiveness of the JUMP Math program of math instruction for improving elementary math achievement.

PLoS ONE, 2019
Students in many western countries struggle to achieve acceptable standards in numeracy despite its recognition as an important 21st century skill.
Tracy Solomon, Annie Dupuis, Arland O'Hara, Min-Na Hockenberry, Jenny Lam, Geraldine Goco, Bruce Ferguson, Rosemary Tannock   +7 more
doaj   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Cost-effectiveness of the Adaptive Implementation of Effective Programs Trial (ADEPT): approaches to adopting implementation strategies

Implementation Science, 2020
Background Theory-based methods to support the uptake of evidence-based practices (EBPs) are critical to improving mental health outcomes. Implementation strategy costs can be substantial, and few have been rigorously evaluated. The purpose of this study
Andria B. Eisman, David W. Hutton, Lisa A. Prosser, Shawna N. Smith, Amy M. Kilbourne   +4 more
doaj   +1 more source

Evaluation and guide for embedding opioid use disorder education in health professions’ curricula

BMC Medical Education, 2023
Background Morbidity and mortality from Opioid Use Disorder is a health crisis in the United States. During the COVID-19 pandemic, there was a devastating increase of 38.4% in overdose deaths from the 12-month period leading up to June 2019 compared with
Julie G. Salvador, Sindy L. Bolaños-Sacoman, Joanna G. Katzman, Ann E. Morrison, Lindsay E. Fox, Jennifer S. Schneider, Snehal R. Bhatt, Tyler W. Kincaid, V. Ann Waldorf   +8 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

A randomized trial of adapted versus standard versions of the Transdiagnostic Intervention for Sleep and Circadian Dysfunction implemented via facilitation and delivered by community mental health providers: improving the “fit” of psychological treatments by adapting to context

Implementation Science
Background Grounded in the Integrated Promoting Action on Research Implementation in Health Services framework (i-PARIHS) and the Replicating Effective Programs framework (REP), the goal is to determine if the use of theory, data and end-user ...
Allison G. Harvey, Emma R. Agnew, Rafael Esteva Hache, Julia M. Spencer, Marlen Diaz, Estephania Ovalle Patino, Anne Milner, Lu Dong, Amy M. Kilbourne, Daniel J. Buysse, Catherine A. Callaway, Laurel D. Sarfan   +11 more
doaj   +1 more source

Preparing to launch the ‘Thinking Healthy Programme’ perinatal depression intervention in Urban Lima, Peru: experiences from the field

Cambridge Prisms: Global Mental Health, 2018
Background.An estimated 19–25% of perinatal women in low- and middle-income countries are affected by depression which, untreated, is associated with multiple health problems for mothers and children.
B. S. Eappen, M. Aguilar, K. Ramos, C. Contreras, M. C. Prom, P. Scorza, B. Gelaye, M. Rondon, G. Raviola, J. T. Galea   +9 more
doaj   +1 more source

Adaptation of an exercise intervention for pregnant women to community-based delivery: a study protocol

BMJ Open, 2020
Introduction Despite well-established guidelines and benefits to exercise, the majority of pregnant women in the USA fail to meet recommended activity levels.
Aline Andres, Elisabet Børsheim, Taren Swindle, Audrey Martinez   +3 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source