Results 31 to 40 of about 109,369 (285)
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Recent work on use of lunar materials for SPS construction [PDF]
, 1980 The feasibility of mounting a small operation on the Moon to productively use lunar materials in support of programs such as the solar power satellite is addressed.
Oneill, G. K.
core +1 more source
Trials, 2020 Background Shared medical appointments (SMAs) have been shown to be an efficient and effective strategy for providing diabetes self-management education and self-management support.
Bethany M. Kwan +10 more
doaj +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Copy That: Guidelines for Replicating Programs to Prevent Teen Pregnancy [PDF]
, 2006 Published jointly with The National Campaign to Prevent Teen Pregnancy, this report provides guidance about the replication of effective pregnancy prevention programs.
Geri Summerville
core
Journal of Experimental Psychopathology, 2019 Understanding attentional biases associated with body dissatisfaction can aid in devising and refining programs to reduce body dissatisfaction. This study compared attention to images of women’s bodies before and after a body satisfaction or body ...
Samantha Withnell +2 more
doaj +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Laying a Solid Foundation: Strategies for Effective Program Replication [PDF]
, 2009 With limited funds available for social investment, policymakers and philanthropists are naturally interested in supporting programs with the greatest chance of effectiveness and the ability to benefit the largest number of people.
Becca Raley, Geri Summerville
core
Journal of Philosophy in Schools, 2015 In this article we report the findings of a randomised control clinical trial that assessed the impact of a Philosophy for Children program and replicated a previous study conducted in Scotland by Topping and Trickey. A Cognitive Abilities Test (CAT in the UK or CogAT in the USA) was administered as a pretest and a posttest to randomly selected ...
Frank Fair +5 more
openaire +2 more sources
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source