Results 41 to 50 of about 16,732 (248)

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Factors contributing to intervention fidelity in a multi-site chronic disease self-management program

Implementation Science, 2006
Background and objectives Disease self-management programs have been a popular approach to reducing morbidity and mortality from chronic disease. Replicating an evidence-based disease management program successfully requires practitioners to ensure ...
Pitt Seraphine, Shippey Claire, Walby Gary, O'Connor Danielle, Burke Somer, Perrin Karen M, McDermott Robert J, Forthofer Melinda S   +7 more
doaj   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Simulating Real-World Slips: Enhanced Kinematic and Neuromuscular Responses to Experimental Slips in the Early vs. Late Stance Phase in Young and Older Adults

Bioengineering
Slips are a leading cause of injury and hospitalization among at-risk individuals. Replicating real-world slips by experimental, mechanical perturbations is essential for characterizing reactive balance mechanisms activated during near-fall situations ...
Marina Geissmann, Nicole Sarah Holliger, Lennart Carlson Neumann, Antonia Maria Eilfort, Linard Filli   +4 more
doaj   +1 more source

Concept Analysis and Implementation Framework of Dementia Day Care Service [PDF]

Zhongguo quanke yixue
Day care service is an important component of the community care service system for elderly people with dementia. However, the concept of dementia day care has not been unified, and its connotation and implementation framework have not been clarified ...
LI Xianwen, LI Xinru, LIU Haining, YIN Yueheng, SHAN Enfang, DING Yaping, NIU Shuzhen, XING Ying
doaj   +1 more source

Healthy Parent Carers: Acceptability and practicability of online delivery and learning through implementation by delivery partner organisations

Health Expectations, 2023
Background Parent carers of disabled children are at increased risk of physical and mental health problems. The Healthy Parent Carers (HPC) programme is a manualised peer‐led group‐based programme that aims to promote parent carer health and wellbeing ...
Alice Garrood, Gretchen Bjornstad, Aleksandra Borek, Annette Gillett, Jenny Lloyd, Sarah Brand, Mark Tarrant, Susan Ball, Annie Hawton, Annabel McDonald, Mary Fredlund, Fleur Boyle, Vashti Berry, Stuart Logan, Christopher Morris   +14 more
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Team effectiveness in a virtual environment: The role of trust and knowledge sharing [PDF]

Strategic Management
Background: In recent years, research efforts have focused on understanding virtual environments and the importance of collaboration in such environments.
Hodžić Naida, Efendić Amina, Kapo Amra   +2 more
doaj   +1 more source

Mycobacterium tuberculosis lipolytic enzymes as potential biomarkers for the diagnosis of active tuberculosis. [PDF]

PLoS ONE, 2011
BACKGROUND: New diagnosis tests are urgently needed to address the global tuberculosis (TB) burden and to improve control programs especially in resource-limited settings.
Belinda Brust, Mélanie Lecoufle, Edouard Tuaillon, Luc Dedieu, Stéphane Canaan, Viviane Valverde, Laurent Kremer   +6 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source