Results 61 to 70 of about 7,284,411 (284)

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Simulating Real-World Slips: Enhanced Kinematic and Neuromuscular Responses to Experimental Slips in the Early vs. Late Stance Phase in Young and Older Adults

Bioengineering
Slips are a leading cause of injury and hospitalization among at-risk individuals. Replicating real-world slips by experimental, mechanical perturbations is essential for characterizing reactive balance mechanisms activated during near-fall situations ...
Marina Geissmann, Nicole Sarah Holliger, Lennart Carlson Neumann, Antonia Maria Eilfort, Linard Filli   +4 more
doaj   +1 more source

Concept Analysis and Implementation Framework of Dementia Day Care Service [PDF]

Zhongguo quanke yixue
Day care service is an important component of the community care service system for elderly people with dementia. However, the concept of dementia day care has not been unified, and its connotation and implementation framework have not been clarified ...
LI Xianwen, LI Xinru, LIU Haining, YIN Yueheng, SHAN Enfang, DING Yaping, NIU Shuzhen, XING Ying
doaj   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

Team effectiveness in a virtual environment: The role of trust and knowledge sharing [PDF]

Strategic Management
Background: In recent years, research efforts have focused on understanding virtual environments and the importance of collaboration in such environments.
Hodžić Naida, Efendić Amina, Kapo Amra   +2 more
doaj   +1 more source

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

Self-Replicating Machines in Continuous Space with Virtual Physics [PDF]

, 2003
JohnnyVon is an implementation of self-replicating machines in continuous two-dimensional space. Two types of particles drift about in a virtual liquid.
Turney, Peter, Robert Ewaschuk, Smith, Arnold, Council Canada, Arnold Smith, Ewaschuk, Robert, Peter Turney (corresponding   +6 more
core   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

JohnnyVon: Self-Replicating Automata in Continuous Two-Dimensional Space [PDF]

, 2002
JohnnyVon is an implementation of self-replicating automata in continuous two-dimensional space. Two types of particles drift about in a virtual liquid. The particles are automata with discrete internal states but continuous external relationships. Their
Turney, Peter, Smith, Arnold, Ewaschuk, Robert   +2 more
core   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source