Results 81 to 90 of about 1,395,428 (175)

Species-Specific Contribution of the Four C-Terminal Amino Acids of Influenza A Virus NS1 Protein to Virulence [PDF]

, 2010
Large-scale sequence analyses of influenza viruses revealed that nonstructural 1 (NS1) proteins from avian influenza viruses have a conserved C-terminal ESEV amino acid motif, while NS1 proteins from typical human influenza viruses have a C-terminal RSKV
Loupias, Josiane, Lacroux, Caroline, Peralta, Brigitte, Soubies, S. M., Soubiès, Sébastien, Loupias, Josyane, Costes, Pierrette, Guérin, Jean-Luc, Volmer, C., Volmer, Christelle, Croville, Guillaume, Soubies, Sebastien Mathieu, Volmer, Romain   +12 more
core   +1 more source

Nanoscale Spatial Organization of ARC High‐ and Low‐Order Assemblies at Excitatory Synapses

Advanced Science, Volume 13, Issue 37, 3 July 2026.
ARC (Activity‐Regulated Cytoskeleton‐Associated protein) mediates synaptic plasticity by forming nanoscale assemblies in neurons. Using super‐resolution microscopy and time‐resolved anisotropy with targeted tagging, the study reveals low‐order ARC assemblies at synapses colocalizing with AMPARs, semi‐circular structures at endocytic zones, and 60–80 nm
Martina Damenti, Giovanna Coceano, Mariline Mendes Silva, Jonatan Alvelid, Chiara Sgattoni, Andrea Volpato, Lea Rems, Luciano A. Masullo, Eduard M. Unterauer, Rafal Kowalewski, Lucie Delemotte, Erdinc Sezgin, Ralf Jungmann, Ilaria Testa   +13 more
wiley   +1 more source

A novel broad-spectrum treatment for respiratory virus infections : influenza-based defective interfering virus provides protection against pneumovirus infection in vivo [PDF]

, 2011
Respiratory viruses represent a major clinical burden. Few vaccines and antivirals are available, and the rapid appearance of resistant viruses is a cause for concern.
Edworthy, Nicole Lynn, Nicole L. Edworthy, Andrew J. Easton, Meng, Bo, Easton, A. J. (Andrew J.), Bo Meng, Scott, P. D. (Paul D.), Marriott, Anthony C., Anthony C. Marriott, Nigel J. Dimmock, Dimmock, N. J., Paul D. Scott   +11 more
core   +1 more source

NaP‐TRAP: A Versatile and Accessible Workflow to Dissect Principles of Translational Regulation and mRNA Stability

Current Protocols, Volume 6, Issue 7, July 2026.
Abstract The translation of messenger RNA (mRNA) into protein is tightly regulated by both cellular trans‐factors and cis‐regulatory elements encoded within transcripts. Although transcript fate can be measured by transcript abundance or translation efficiency, separating the contribution of individual cis‐element within a single transcript is an ...
Amit Gupta, Anna Z. Struba, Srihari Madhavan, Ethan Strayer, Jean‐Denis Beaudoin   +4 more
wiley   +1 more source

Fail to Win: How Schadenfreude and Competitive Traits Predict Download Intention in Mobile Game Fail Ads

Psychology &Marketing, Volume 43, Issue 7, Page 1560-1577, July 2026.
ABSTRACT In mobile game advertising, failure‐depicting advertisements, which intentionally showcase unsuccessful gameplay scenarios, have emerged as an unexpectedly effective promotional strategy. This study examines the psychological mechanisms underlying the effectiveness of fail advertisements, with particular attention to the emotional response of ...
Moon Joonhyun, Yeolib Kim, Boreum Choi, Hanbyul Choi   +3 more
wiley   +1 more source

Countering FIMI by Digital Authoritarianisms: Audience Architecture and Reverse Language Engineering

Global Policy, Volume 17, Issue S2, Page S67-S82, July 2026.
ABSTRACT Foreign information manipulation and interference (FIMI) campaigns on social media are currently both more accessible and more impactful than the North Atlantic Treaty Organization's (NATO) or European Union's (EU), offering their opponents superiority and efficiency on those platforms.
Michelangelo Conoscenti
wiley   +1 more source

Pivotal role of the non-hr origin of DNA replication in the genesis of defective interfering baculoviruses [PDF]

, 2002
The generation of deletion mutants, including defective interfering viruses, upon serial passage of Spodoptera exigua multicapsid nucleopolyhedrovirus (SeMNPV) in insect cell culture has been studied. Sequences containing the non-homologous region origin
Pijlman, G.P., Yang, K., Martens, D.E., Goldbach, R.W., Vlak, J.M., Dortmans, Jos C. F. M., Vermeesch, Angela M. G., Goldbach, Rob W., Martens, Dirk E., Pijlman, Gorben P., Yang, Kai, Vlak, Just M., Dortmans, J.C.F.M., Vermeesch, A.M.G.   +13 more
core   +1 more source

Integrative Insights Into DYRK1A From Molecular Function to Therapeutic Advancement

Chemical Biology &Drug Design, Volume 108, Issue 1, July 2026.
At the center the 3D structure of DYRK1A has been displayed. The dual‐function of DYRK1A involved in cancer and neurodegeneration, i.e., its overexpression drives Down syndrome, neurodegenerative disease etc., and underexpression causes intellectual disability, seizures, etc.
Sampriti Paul, Sonal Dubey, Prashant Tiwari   +2 more
wiley   +1 more source

Reassortment incompetent live attenuated and replicon influenza vaccines provide improved protection against influenza in piglets

npj Vaccines
Swine influenza A viruses (swIAV) cause an economically important respiratory disease in modern pig production. Continuous virus transmission and antigenic drift are difficult to control in enzootically infected pig herds. Here, antibody-positive piglets
Annika Graaf-Rau, Kathrin Schmies, Angele Breithaupt, Kevin Ciminski, Gert Zimmer, Artur Summerfield, Julia Sehl-Ewert, Kathrin Lillie-Jaschniski, Carina Helmer, Wiebke Bielenberg, Elisabeth grosse Beilage, Martin Schwemmle, Martin Beer, Timm Harder   +13 more
doaj   +1 more source

Chikungunya virus nonstructural protein 2 inhibits type I/II interferon-stimulated JAK-STAT signaling [PDF]

, 2010
Chikungunya virus (CHIKV) is an emerging human pathogen transmitted by mosquitoes. Like that of other alphaviruses, CHIKV replication causes general host shutoff, leading to severe cytopathicity in mammalian cells, and inhibits the ability of infected ...
Ligtenberg, M., Suhrbier, A., Corinne Geertsema, Esther Schnettler, Fros, J., Just M. Vlak, Maarten Ligtenberg, Geertsema, C., Suhrbier, Andreas, Wen Jun Liu, Natalie A. Prow, Vlak, J.M., Dana L. Vanlandingham, Ligtenberg, Maarten, Khromykh, Alexander A., Jelke J. Fros, Vanlandingham, D.L., Vlak, Just M., Schnettler, E., Fros, J.J., Gorben P. Pijlman, Pijlman, G.P., Liu, W.J., Khromykh, A.A., Prow, A., Fros, Jelke J., Vanlandingham, Dana L., Liu, Wen Jun, Geertsema, Corinne, Prow, Natalie A., Alexander A. Khromykh, Schnettler, Esther, Pijlman, Gorben P., Andreas Suhrbier, Prow, N.A.   +34 more
core   +1 more source