Results 61 to 70 of about 1,395,428 (175)

Activation of the beta interferon promoter by paramyxoviruses in the absence of virus protein synthesis [PDF]

, 2012
Conflicting reports exist regarding the requirement for virus replication in interferon (IFN) induction by paramyxoviruses. Our previous work has demonstrated that pathogen-associated molecular patterns capable of activating the IFN-induction cascade are
Killip, M. J., Randall, RE, Goodbourn, S., Precious, BL, Young, D. F., Precious, B. L., Randall, R. E., S. Goodbourn, Goodbourn, S, D. F. Young, R. E. Randall, M. J. Killip, Young, DF, Killip, MJ, B. L. Precious   +14 more
core   +1 more source

Reframing Technology and Ethics in Corneal Xenotransplantation: A Scoping Review of Standards and Safety in Ophthalmology

Health Care Science, EarlyView.
Bringing attention to the moral dilemmas raised by xenotransplantation and the continuous creation of standardized frameworks for donor technology and biosafety risk management, with a focus on striking a balance between patient safety, medical innovation, and ethical obligation.
Sankhajyoti Saha, Moubani Dutta, Agnihiya Bosu   +2 more
wiley   +1 more source

Generation of replication-proficient Influenza Virus NS1 point mutants with interferon-hyperinducer phenotype [PDF]

, 2014
The NS1 protein of influenza A viruses is the dedicated viral interferon (IFN)-antagonist. Viruses lacking NS1 protein expression cannot multiply in normal cells but are viable in cells deficient in their ability to produce or respond to IFN.
Fernández, Yolanda, Juan Ortín, Randall, Richard E, Richard E. Randall (190211), Killip, Marian J, Víctor J Asensio, Bengoechea, José A, Pérez-Cidoncha, M, Marian J. Killip (571160), Marian J Killip, Maite Pérez-Cidoncha (195699), Ortín, Juan, Killip, MJ, Ortín, J, Richard E Randall, Juan Ortín (5649007), Yolanda Fernández, Fernández, Y, Asensio, Víctor J, Randall, RE, José A Bengoechea, José A. Bengoechea (124595), Pérez-Cidoncha, Maite, Bengoechea, JA, Víctor J. Asensio (571161), Bengoechea, José A; id_orcid, Maite Pérez-Cidoncha, Asensio, VJ, Yolanda Fernández (268684), Bengoechea, Jose Antonio, Asensio, Víctor José, Randall, Richard E.   +31 more
core   +2 more sources

A global assessment of the viruses transmitted by the peach‐potato aphid (Myzus persicae)

Agricultural and Forest Entomology, EarlyView.
The viruses transmitted by Myzus persicae, including proportions by family, order and transmission type (persistent, semi‐persistent and non‐persistent), are provided. Latin binomials and common names are documented for each virus Virus presence in GB matches well with the rest of NW Europe, but with 25 exceptions.
James R. Bell, Yoann Bourhis
wiley   +1 more source

A Promising IFN-Deficient System to Manufacture IFN-Sensitive Influenza Vaccine Virus

Frontiers in Cellular and Infection Microbiology, 2018
Interferon (IFN)-sensitive and replication-incompetent influenza viruses are likely to be the alternatives to inactivated and attenuated virus vaccines.
Can Chen, Can Chen, Wenhui Fan, Jing Li, Jing Li, Weinan Zheng, Shuang Zhang, Limin Yang, Di Liu, Di Liu, Wenjun Liu, Wenjun Liu, Lei Sun, Lei Sun   +13 more
doaj   +1 more source

A new vaccination regimen using adenovirus-vectored vaccine confers effective protection against African swine fever virus in swine

Emerging Microbes and Infections, 2023
African swine fever (ASF) is an acute and highly contagious lethal infectious disease in swine that severely threatens the global pig industry. At present, a safe and efficacious vaccine is urgently required to prevent and control the disease.
Wenming Liu, Hengchun Li, Bo Liu, Tianxing Lv, Chenchen Yang, Si Chen, Liqiang Feng, Liangxue Lai, Ziyuan Duan, Xinwen Chen, Pingchao Li, Suhua Guan, Ling Chen   +12 more
doaj   +1 more source

The RNA Capping Enzyme Domain in Protein A is Essential for Flock House Virus Replication [PDF]

, 2018
The nodavirus flock house virus (FHV) and the alphavirus Semliki Forest virus (SFV) show evolutionarily intriguing similarities in their replication complexes and RNA capping enzymes. In this study, we first established an efficient FHV trans-replication
Ahola, Tero, Maija K. Pietilä, Yu Chen, Quirin, Tania, Tero Ahola, Guo, Deyin, Chen, Yu, Maija K. Pietilä, Deyin Guo, Tania Quirin, Pietilä, Maija K.   +10 more
core   +1 more source

Vaccinations During Pregnancy Protect the Mother–Infant Dyad and Are Generally Safe

Acta Paediatrica, EarlyView.
ABSTRACT Aim Vaccination in pregnancy has a critical impact on mothers, foetuses and infants. The aim of this paper was to summarise key points presented by experts attending the 12th Maria Delivoria‐Papadopoulos Perinatal Symposium in March 2025 and further expand and update them.
Ariadne Malamitsi‐Puchner, Despina D. Briana, Gian Carlo Di Renzo   +2 more
wiley   +1 more source

Dengue virus inhibits alpha interferon signaling by reducing STAT2 expression [PDF]

, 2005
Type 1 interferons (IFN-?/?) are key mediators of innate antiviral responses but havelittle effect on established replication of dengue viruses, which are mosquito-borneflaviviruses of immense global health importance.
Jones, M, Jacobs, M, Ball, S, Hibbert, L, Foster, G, Davidson, AD, Foster, GR, Davidson, A, Gruenwald, P, Schlaak, J   +9 more
core   +1 more source

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

British Journal of Pharmacology, EarlyView.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown, Alan Armstrong, David J. Mann   +2 more
wiley   +1 more source