Results 41 to 50 of about 1,395,428 (175)

Immune Response to Herpes Simplex Virus Infection and Vaccine Development

Vaccines, 2020
Herpes simplex virus (HSV) infections are among the most common viral infections and usually last for a lifetime. The virus can potentially be controlled with vaccines since humans are the only known host.
Anthony C. Ike, Chisom J. Onu, Chukwuebuka M. Ononugbo, Eleazar E. Reward, Sophia O. Muo   +4 more
doaj   +1 more source

Murine leukemia virus (MLV) replication monitored with fluorescent proteins [PDF]

, 2006
Background: Cancer gene therapy will benefit from vectors that are able to replicate in tumor tissue and cause a bystander effect. Replication-competent murine leukemia virus (MLV) has been described to have potential as cancer therapeutics, however, MLV
Erlwein, Otto, Bittner, Alexandra, Sliva, Katja, Schnierle, Barbara   +3 more
core   +1 more source

Inhibitors of the interferon response enhance virus replication in vitro. [PDF]

, 2014
This work was supported by the University of St Andrews (CSA, CES) and the Wellcome Trust (grant 087751/A/08/Z) (RER).Virus replication efficiency is influenced by two conflicting factors, kinetics of the cellular interferon (IFN) response and induction ...
Richard E. Randall, Catherine S. Adamson, Catherine S Adamson, Claire E Stewart, Richard E Randall, Adamson, Catherine S, Stewart, Claire Emma, Randall, Richard Edward, Claire E. Stewart   +8 more
core   +1 more source

Investigations of the molecular determinants of maize streak virus replication [PDF]

, 1999
Includes bibliographical references.Geminiviruses replicate via a rolling circle mechanism, which initiates at the origin of replication located within the long intergenic region (LIR).
Willment, Janet Anne
core   +1 more source

Influence of retinoblastoma-related gene silencing on the initiation of DNA replication by African cassava mosaic virus Rep in cells of mature leaves in Nicotiana benthamiana plants [PDF]

, 2011
Background Geminiviruses mainly infect terminally differentiated tissues and cells in plants. They need to reprogramme host cellular machinery for DNA replication.
Yule Liu, Bruce, Gareth, Bruce Gareth, Liu, Yule, Liu Yule, Gareth Bruce, Nongnong Shi, Gu, Mei, Hong, Yiguo, Shi Nongnong, Yiguo Hong, Gu Mei, Shi, Nongnong, Hong Yiguo, Mei Gu   +14 more
core   +1 more source

Characterization of a Replication-Incompetent Pseudorabies Virus Mutant Lacking the Sole Immediate Early Gene IE180

mBio, 2014
The alphaherpesvirus pseudorabies virus (PRV) encodes a single immediate early gene called IE180. The IE180 protein is a potent transcriptional activator of viral genes involved in DNA replication and RNA transcription.
Brendan W. Wu, Esteban A. Engel, Lynn W. Enquist   +2 more
doaj   +1 more source

Immunogenicity of HIV-1-Based Virus-Like Particles with Increased Incorporation and Stability of Membrane-Bound Env

Vaccines, 2021
An optimal prophylactic vaccine to prevent human immunodeficiency virus (HIV-1) transmission should elicit protective antibody responses against the HIV-1 envelope glycoprotein (Env).
Christopher A. Gonelli, Hannah A. D. King, Charlene Mackenzie, Secondo Sonza, Rob J. Center, Damian F. J. Purcell   +5 more
doaj   +1 more source

FMDV replicons encoding green fluorescent protein are replication competent [PDF]

, 2014
The study of replication of viruses that require high bio-secure facilities can be accomplished with less stringent containment using non-infectious 'replicon' systems. The FMDV replicon system (pT7rep) reported by Mclnerney et al. (2000) was modified by
Stonehouse, Nicola J., Tulloch, Fiona Ashley, Ryan, MD, Rowlands, DJ, Jackson, T, Pathania, Uday, Ryan, Martin D, Tuthill, Toby, Lamond, Angus I.; id_orcid, Rowlands, David J, Nicholson, J, Rowlands, David J., Tulloch, F, Luke, GA, Luke, Garry A., Nicholson, John, Lamond, Angus I., Luke, Garry A, Lamond, Angus I, Haas, Juergen, Ryan, Martin D., Tuthill, T, Hass, Juergen, Tulloch, Fiona, Luke, Garry Alec, Stonehouse, Nicola J, Jackson, Terry, Lamond, AI, Ryan, Martin Denis, Pathania, U, Haas, J, Pathania, Uday Singh, Stonehouse, NJ   +32 more
core   +1 more source

Multiscale model of defective interfering particle replication for influenza A virus infection in animal cell culture.

PLoS Computational Biology, 2021
Cell culture-derived defective interfering particles (DIPs) are considered for antiviral therapy due to their ability to inhibit influenza A virus (IAV) production. DIPs contain a large internal deletion in one of their eight viral RNAs (vRNAs) rendering
Daniel Rüdiger, Lars Pelz, Marc D Hein, Sascha Y Kupke, Udo Reichl   +4 more
doaj   +1 more source

The Viral Replication Complex Is Associated with the Virulence of Newcastle Disease Virus [PDF]

, 2010
Virulent strains of Newcastle disease virus ([NDV] also known as avian paramyxovirus type 1) can be discriminated from low-virulence strains by the presence of multiple basic amino acid residues at the proteolytic cleavage site of the fusion (F) protein.
Peeters, B.P.H., G. Koch, B. P. H. Peeters, Rottier, P.J.M., Dortmans, J.C.F.M., J. C. F. M. Dortmans, P. J. M. Rottier, Koch, G.   +7 more
core   +1 more source