Results 21 to 30 of about 1,395,428 (175)

Multivalent viral particles elicit safe and efficient immunoprotection against Nipah Hendra and Ebola viruses

npj Vaccines, 2022
Experimental vaccines for the deadly zoonotic Nipah (NiV), Hendra (HeV), and Ebola (EBOV) viruses have focused on targeting individual viruses, although their geographical and bat reservoir host overlaps warrant creation of multivalent vaccines.
Duncan G. Ithinji, David W. Buchholz, Shahrzad Ezzatpour, I. Abrrey Monreal, Yu Cong, Julie Sahler, Amandip Singh Bangar, Brian Imbiakha, Viraj Upadhye, Janie Liang, Andrew Ma, Birgit Bradel-Tretheway, Benjamin Kaza, Yao Yu Yeo, Eun Jin Choi, Gunner P. Johnston, Louis Huzella, Erin Kollins, Saurabh Dixit, Shuiqing Yu, Elena Postnikova, Victoria Ortega, Avery August, Michael R. Holbrook, Hector C. Aguilar   +24 more
doaj   +1 more source

Generation of Premature Termination Codon (PTC)-Harboring Pseudorabies Virus (PRV) via Genetic Code Expansion Technology

Viruses, 2022
Despite many efforts and diverse approaches, developing an effective herpesvirus vaccine remains a great challenge. Traditional inactivated and live-attenuated vaccines always raise efficacy or safety concerns. This study used Pseudorabies virus (PRV), a
Tong-Yun Wang, Guo-Ju Sang, Qian Wang, Chao-Liang Leng, Zhi-Jun Tian, Jin-Mei Peng, Shu-Jie Wang, Ming-Xia Sun, Fan-Dan Meng, Hao Zheng, Xue-Hui Cai, Yan-Dong Tang   +11 more
doaj   +1 more source

Nonclinical pharmacokinetics and biodistribution of VSV-GP using methods to decouple input drug disposition and viral replication

Molecular Therapy: Methods & Clinical Development, 2023
Viral replication places oncolytic viruses (OVs) in a unique niche in the field of drug pharmacokinetics (PK) as their self-amplification obscures exposure-response relationships.
Richard Dambra, Andrea Matter, Kaitlynn Graca, Saeed Salehin Akhand, Saurin Mehta, Ashlee Bell-Cohn, Joyce M. Swenson, Sadia Abid, Dongyue Xin, Cedric Lewis, Luke Coyle, Min Wang, Kathleen Bunosso, Michelle Maugiri, Richard Ruiz, Corey M. Cirillo, Birgit Fogal, Christine Grimaldi, Adam Vigil, Charles Wood, Joseph Ashour   +20 more
doaj   +1 more source

Attenuating RNA Viruses with Expanded Genetic Codes to Evoke Adjustable Immune Response in PylRS-${\mathbf{tRNA}}_{\mathbf{CUA}}^{\mathbf{Pyl}}$ Transgenic Mice

Vaccines, 2023
Ribonucleic acid (RNA) viruses pose heavy burdens on public-health systems. Synthetic biology holds great potential for artificially controlling their replication, a strategy that could be used to attenuate infectious viruses but is still in the ...
Zhetao Zheng, Xuesheng Wu, Yu Wang, Xu Yang, Hongmin Chen, Yuxuan Shen, Yuelin Yang, Qing Xia   +7 more
doaj   +1 more source

Application of pseudotyped virus particles to monitor Ebola virus and SARS-CoV-2 viral entry in human cell lines

STAR Protocols, 2021
Summary: Experimental work on highly pathogenic viruses such as Ebola virus (EBOV) and severe acute respiratory syndrome coronavirus-2 requires high-level biosafety facilities.
Madeleine Eichler, Ebru Aksi, Josef Pfeilschifter, Gergely Imre   +3 more
doaj   +1 more source

Type I IFN signaling limits hemorrhage-like disease after infection with Japanese encephalitis virus through modulating a prerequisite infection of CD11b+Ly-6C+ monocytes

Journal of Neuroinflammation, 2021
Background The crucial role of type I interferon (IFN-I, IFN-α/β) is well known to control central nervous system (CNS) neuroinflammation caused by neurotrophic flaviviruses such as Japanese encephalitis virus (JEV) and West Nile virus.
Ajit Mahadev Patil, Jin Young Choi, Seong Ok Park, Erdenebelig Uyangaa, Bumseok Kim, Koanhoi Kim, Seong Kug Eo   +6 more
doaj   +1 more source

A chemical method for generating live-attenuated, replication-defective DNA viruses for vaccine development

Cell Reports: Methods, 2022
Summary: The development of a chemically attenuated, replication-incompetent virus vaccine can provide protection against diseases caused by DNA viruses.
Dabbu Kumar Jaijyan, Kavitha Govindasamy, Moses Lee, Hua Zhu   +3 more
doaj   +1 more source

Ebola Virus Disease Vaccines: Development, Current Perspectives & Challenges

Vaccines, 2023
The global outgoing outbreaks of Ebola virus disease (EVD) in different regions of Sudan, Uganda, and Western Africa have brought into focus the inadequacies and restrictions of pre-designed vaccines for use in the battle against EVD, which has affirmed ...
Sumira Malik, Shristi Kishore, Sagnik Nag, Archna Dhasmana, Subham Preetam, Oishi Mitra, Darwin A. León-Figueroa, Aroop Mohanty, Vijay Kumar Chattu, Marjan Assefi, Bijaya K. Padhi, Ranjit Sah   +11 more
doaj   +1 more source

Immunization of MERS-CoV-2-infected mice with a sublethal dose of MERS-CoV or VRP-MERS-S

STAR Protocols, 2023
Summary: Here, we detail the immunization of mice with a sublethal dose of MERS-CoV or two doses of replication-incompetent alphavirus replicon particles expressing MERS-CoV spike protein.
Jian Zheng, Rudra Channappanavar, Stanley Perlman   +2 more
doaj   +1 more source

RNA interference targets arbovirus replication in Culicoides cells [PDF]

, 2013
Arboviruses are transmitted to vertebrate hosts by biting arthropod vectors such as mosquitoes, ticks and midges. These viruses replicate in both arthropods and vertebrates and are thus exposed to different antiviral responses in these organisms.
Varela, Mariana, Esther Schnettler, Ratinier, Maxime, Shaw, Andrew, Palmarini, Massimo, Kohl, Alain, Mariana Varela, Mick Watson, Elliott, Richard M., Alain Kohl, Maxime Ratinier, McFarlane, Melanie, Shaw, Andrew E., Elliott, Richard, Richard M, Massimo Palmarini, Schnettler, Esther, E. Shaw, Watson, Mick, A Alain Kohla, Melanie Mcfarlane   +20 more
core   +1 more source