Results 11 to 20 of about 1,395,428 (175)

Azathioprine Inhibits Hepatitis A Virus Replication In Vitro [PDF]

Pathogens
Hepatitis A virus (HAV) infection can occasionally cause acute severe hepatitis. Patients with this disease sometimes need to undergo liver transplantation with immunosuppressants.
Tatsuo Kanda, Reina Sasaki-Tanaka, Hiroyuki Abe, Takeshi Yokoo, Akira Sakamaki, Kazunao Hayashi, Hiroteru Kamimura, Kenya Kamimura, Ryota Masuzaki, Hirofumi Kogure, Hiroaki Okamoto, Shuji Terai   +11 more
doaj   +2 more sources

Molecular and Replication Dynamic Profiling of Regionally Important Pestivirus bovis Subgenotypes from Hungary [PDF]

Animals
This study investigated the in vitro replication kinetics and molecular characteristics of five field isolates of bovine viral diarrhea virus (BVDV) representing subgenotypes 1b, 1d, and 1f, currently circulating in Hungary.
István Kiss, Eszter Kaszab, Krisztina Bali, Renáta Varga-Kugler, Scott Callison, Derek E. Moormeier, Liliana Cubas-Gaona, Zalán Homonnay, Krisztián Bányai   +8 more
doaj   +2 more sources

Immunostimulatory nucleic acid nanoparticles establish antiviral state to inhibit viral infection and replication [PDF]

Journal of Virology
Establishing a rapid, broad-spectrum antiviral state in human cells offers a promising strategy to combat viral infections, especially when vaccines or pathogen-specific treatments are unavailable.
Martin Panigaj, Cassandra Catacalos-Goad, Anh Ha, Valery Z. Grdzelishvili, Kirill A. Afonin   +4 more
doaj   +2 more sources

Replication-incompetent rabies virus vector harboring glycoprotein gene of lymphocytic choriomeningitis virus (LCMV) protects mice from LCMV challenge. [PDF]

PLoS Neglected Tropical Diseases, 2018
BACKGROUND:Lymphocytic choriomeningitis virus (LCMV) causes a variety of diseases, including asymptomatic infections, meningitis, and congenital infections in the fetus of infected mother.
Mutsuyo Takayama-Ito, Chang-Kweng Lim, Yukie Yamaguchi, Guillermo Posadas-Herrera, Hirofumi Kato, Itoe Iizuka, Md Taimur Islam, Kinjiro Morimoto, Masayuki Saijo   +8 more
doaj   +3 more sources

Replication-incompetent viral vaccine vectors ChAdOx1 and MVA as tools for evaluating T-cell responses to naturally processed antigens in vitro [PDF]

Virus Research
Assessing T-cell responses is critical for vaccine development. In vitro methods using SARS-CoV-2 or recombinant vaccinia virus with B cells effectively activate T-cells but require stringent biosafety conditions.
Salik Nazki, Jesús Reiné, Reshma Kailath, Sarah Gilbert, Bruno Douradinha   +4 more
doaj   +2 more sources

Replication-competent adenovirus reporters utilizing endogenous viral expression architecture [PDF]

Journal of Virology
Adenoviruses are double-stranded DNA viruses widely used as platforms for vaccines, oncolytics, and gene delivery. However, tools for studying adenoviral gene expression in real time during infection remain limited. Here, we describe a set of fluorescent
Claire M. O’Brien, Lorenzo Serra, Molly R. Patterson, Reyes W. Acosta, Alison Yu, Daniel T. Claiborne, Alexander M. Price   +6 more
doaj   +2 more sources

A replication-incompetent CD154/40L recombinant vaccinia virus induces direct and macrophage-mediated antitumor effects in vitro and in vivo

OncoImmunology, 2019
CD40 triggering may result in antitumor effects of potentially high clinical relevance. To gain insights important for patient selection and to identify adequate targeting techniques, we investigated CD40 expression in human cancer tissues and generated ...
Valeria Governa, Alvaro Brittoli, Valentina Mele, Maurizio Pinamonti, Luigi Terracciano, Simone Muenst, Giandomenica Iezzi, Giulio Cesare Spagnoli, Paul Zajac, Emanuele Trella   +9 more
doaj   +2 more sources

A replication-incompetent virus possessing an uncleavable hemagglutinin as an influenza vaccine. [PDF]

Vaccine, 2012
Katsura H, Iwatsuki-Horimoto K, Fukuyama S, Watanabe S, Sakabe S, Hatta Y, Murakami S, Shimojima M, Horimoto T, Kawaoka Y.   +9 more
europepmc   +2 more sources

Variations in the Abortive HIV-1 RNA Hairpin Do Not Impede Viral Sensing and Innate Immune Responses

Pathogens, 2021
The highly conserved trans-acting response element (TAR) present in the RNA genome of human immunodeficiency virus 1 (HIV-1) is a stably folded hairpin structure involved in viral replication.
Melissa Stunnenberg, John L. van Hamme, Atze T. Das, Ben Berkhout, Teunis B. H. Geijtenbeek   +4 more
doaj   +1 more source

A Combination of M50I and V151I Polymorphic Mutations in HIV-1 Subtype B Integrase Results in Defects in Autoprocessing

Viruses, 2021
We have recently reported that a recombinant HIV-1NL4.3 containing Met-to-Ile change at codon 50 of integrase (IN) (IN:M50I) exhibits suppression of the virus release below 0.5% of WT HIV, and the released viral particles are replication-incompetent due ...
Jun Yang, Ming Hao, Muhammad A. Khan, Muhammad T. Rehman, Helene C. Highbarger, Qian Chen, Suranjana Goswami, Brad T. Sherman, Catherine A. Rehm, Robin L. Dewar, Weizhong Chang, Tomozumi Imamichi   +11 more
doaj   +1 more source