Results 1 to 10 of about 1,390,462 (206)

A replication-incompetent virus possessing an uncleavable hemagglutinin as an influenza vaccine [PDF]

Vaccine, 2012
Vaccination is one of the most effective measures to protect against influenza virus infection. Inactivated and live-attenuated influenza vaccines are available; however, their efficacy is suboptimal. To develop a safe and more immunogenic vaccine, we produced a novel replication-incompetent influenza virus that possesses uncleavable hemagglutinin (HA)
Yoshihiro Kawaoka, Kiyoko Iwatsuki-Horimoto   +1 more
exaly   +5 more sources

Replication-incompetent rabies virus vector harboring glycoprotein gene of lymphocytic choriomeningitis virus (LCMV) protects mice from LCMV challenge. [PDF]

PLoS Neglected Tropical Diseases, 2018
BACKGROUND:Lymphocytic choriomeningitis virus (LCMV) causes a variety of diseases, including asymptomatic infections, meningitis, and congenital infections in the fetus of infected mother.
Mutsuyo Takayama-Ito, Chang-Kweng Lim, Yukie Yamaguchi, Guillermo Posadas-Herrera, Hirofumi Kato, Itoe Iizuka, Md Taimur Islam, Kinjiro Morimoto, Masayuki Saijo   +8 more
doaj   +6 more sources

A replication-incompetent CD154/40L recombinant vaccinia virus induces direct and macrophage-mediated antitumor effects in vitro and in vivo [PDF]

OncoImmunology, 2019
CD40 triggering may result in antitumor effects of potentially high clinical relevance. To gain insights important for patient selection and to identify adequate targeting techniques, we investigated CD40 expression in human cancer tissues and generated ...
Valeria Governa, Alvaro Brittoli, Valentina Mele, Maurizio Pinamonti, Luigi Terracciano, Simone Muenst, Giandomenica Iezzi, Giulio Cesare Spagnoli, Paul Zajac, Emanuele Trella   +9 more
doaj   +6 more sources

Azathioprine Inhibits Hepatitis A Virus Replication In Vitro [PDF]

Pathogens
Hepatitis A virus (HAV) infection can occasionally cause acute severe hepatitis. Patients with this disease sometimes need to undergo liver transplantation with immunosuppressants.
Tatsuo Kanda, Reina Sasaki-Tanaka, Hiroyuki Abe, Takeshi Yokoo, Akira Sakamaki, Kazunao Hayashi, Hiroteru Kamimura, Kenya Kamimura, Ryota Masuzaki, Hirofumi Kogure, Hiroaki Okamoto, Shuji Terai   +11 more
doaj   +2 more sources

Characterization of a Replication-Incompetent Pseudorabies Virus Mutant Lacking the Sole Immediate Early Gene IE180 [PDF]

mBio, 2014
The alphaherpesvirus pseudorabies virus (PRV) encodes a single immediate early gene called IE180. The IE180 protein is a potent transcriptional activator of viral genes involved in DNA replication and RNA transcription.
Brendan W. Wu, Esteban A. Engel, Lynn W. Enquist   +2 more
doaj   +3 more sources

Immunostimulatory nucleic acid nanoparticles establish antiviral state to inhibit viral infection and replication [PDF]

Journal of Virology
Establishing a rapid, broad-spectrum antiviral state in human cells offers a promising strategy to combat viral infections, especially when vaccines or pathogen-specific treatments are unavailable.
Martin Panigaj, Cassandra Catacalos-Goad, Anh Ha, Valery Z. Grdzelishvili, Kirill A. Afonin   +4 more
doaj   +2 more sources

Molecular and Replication Dynamic Profiling of Regionally Important Pestivirus bovis Subgenotypes from Hungary [PDF]

Animals
This study investigated the in vitro replication kinetics and molecular characteristics of five field isolates of bovine viral diarrhea virus (BVDV) representing subgenotypes 1b, 1d, and 1f, currently circulating in Hungary.
István Kiss, Eszter Kaszab, Krisztina Bali, Renáta Varga-Kugler, Scott Callison, Derek E. Moormeier, Liliana Cubas-Gaona, Zalán Homonnay, Krisztián Bányai   +8 more
doaj   +2 more sources

Perspectives on replication-incompetent nasal influenza virus vaccines

Expert Review of Vaccines, 2012
Influenza is an emerging as well as resurging contagious disease with a worldwide impact on public health. Although broad administration of the licensed influenza virus (IFV) vaccines has mitigated the disease in many countries over the years, there are intrinsic problems associated with them.
De-Chu C Tang
exaly   +3 more sources

Establishment of an induced pluripotent cell line from Taiwan black silkie chick embryonic fibroblasts for replication-incompetent virus production. [PDF]

Sci Rep, 2019
AbstractThe objective of this study was to establish a versatile cell line for replication-incompetent virus production and inactivation with formaldehyde to generate a model of cell-based vaccine manufacturing process. To achieve this goal, we took advantage of the easily accessed chick embryonic fibroblasts.
Liou JF, Wu WR, Chen LR, Shiue YL.
europepmc   +4 more sources

A Replication-Incompetent PB2-Knockout Influenza A Virus Vaccine Vector [PDF]

Journal of Virology, 2012
ABSTRACTVaccination is the primary form of protection from influenza virus infection. We recently developed a replication-incompetent PB2-knockout (PB2-KO) influenza virus that possesses a reporter gene (the green fluorescent protein gene) in the coding region of the PB2 segment.
Yoshihiro Kawaoka, Makoto Ozawa, Hiroaki Katsura   +2 more
exaly   +3 more sources