Results 141 to 150 of about 3,335,276 (377)

PolySUMOylation of PCNA and Rad52 restricts centromeric recombination in fission yeast

Nature Communications
SUMOylation, a conserved post-translational modification in eukaryotes, regulates protein function, localization, and stability. However, the role of SUMO chains in genome maintenance is still emerging.
Katarzyna Markowska, Ireneusz Litwin, Dorota Misiorna, Julia Kończak, Aleksandra Bogdańska, Paulina Tomaszewska, Michał Tracz, Mika Haenen, Karol Kramarz   +8 more
doaj   +1 more source

SARS-CoV-2 spike D614G change enhances replication and transmission

Nature, 2021
Bin Zhou, T. T. N. Thao, D. Hoffmann, A. Taddeo, N. Ebert, Fabien Labroussaa, Anne Pohlmann, Jacqueline King, Silvio Steiner, Jenna N. Kelly, J. Portmann, N. Halwe, Lorenz Ulrich, B. Trüeb, Xiaoyu Fan, B. Hoffmann, Li Wang, Lisa Thomann, Xudong Lin, H. Stalder, B. Pozzi, Simone de Brot, Nannan Jiang, D. Cui, Jaber Hossain, Malania M. Wilson, Matthew W. Keller, T. Stark, J. Barnes, R. Dijkman, J. Jores, C. Benarafa, D. Wentworth, V. Thiel, M. Beer   +34 more
semanticscholar   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication.

Archives of General Psychiatry, 2005
R. Kessler, P. Berglund, Olga V Demler, R. Jin, K. Merikangas, E. Walters   +5 more
semanticscholar   +1 more source

Hallmarks of DNA replication stress.

Molecules and Cells, 2022
Sneha Saxena, L. Zou
semanticscholar   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Ultradeep analysis of pretherapy HIV predicts large and genetically complex reservoirs during antiretroviral therapy

Journal of Virus Eradication, 2019
K. Huik, J. Hattori, V. Boltz, J. Rausch, W. Shao, M. Kearney, J. Coffin, F. Maldarelli   +7 more
doaj   +1 more source

Better reporting of interventions: template for intervention description and replication (TIDieR) checklist and guide

British medical journal, 2014
T. Hoffmann, P. Glasziou, I. Boutron, R. Milne, R. Perera, D. Moher, D. Altman, V. Barbour, H. Macdonald, M. Johnston, S. Lamb, M. Dixon-Woods, P. McCulloch, J. Wyatt, A. Chan, S. Michie   +15 more
semanticscholar   +1 more source

The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro

Antiviral Research, 2020
L. Caly, J. Druce, M. Catton, D. Jans, K. Wagstaff   +4 more
semanticscholar   +1 more source

Targeting replication stress in cancer therapy

Nature reviews. Drug discovery, 2022
A. D. da Costa, Dipanjan Chowdhury, G. Shapiro, A. D’Andrea, P. Konstantinopoulos   +4 more
semanticscholar   +1 more source