Results 291 to 300 of about 3,159,718 (373)

Single-molecule sequencing maps replication dynamics across the fission yeast genome, including centromeres

Díez-Santos I, Thiyagarajan S, Rogers AM, Watson AT, Carr AM, Nieduszynski CA.   +5 more
europepmc   +1 more source

A metric of knowledge as information compression reflects reproducibility predictions for biomedical experiments. [PDF]

R Soc Open Sci
Fanelli D, Tan PB, Amaral OB, Neves K.
europepmc   +1 more source

Colonic Pericryptal Fibroblast Sheath: Replication, Migration, and Cytodifferentiation of a Mesenchymal Cell System in Adult Tissue

, 1968
Gordon I. Kaye, Nathan Lane, Robert Pascal   +2 more
openalex   +1 more source

Considerations for Issues of Regression to the Mean and Contextual Effects in Clinical Trials for Pain in Rheumatic Diseases

Arthritis Care &Research, Accepted Article.
Recently, there has been growing discussion about how to best assess pain in clinical trials in rheumatic diseases. Reliable measurement of pain outcomes is essential for accurately determining the effectiveness of treatments. While pain intensity is the most common measure of change in pain trials, other pain‐related measures, such as pain ...
Yen T. Chen, Guohao Zhu, Afton L. Hassett, Daniel Clauw, Susan L. Murphy   +4 more
wiley   +1 more source

Essential role for PfHSP40 in asexual replication and thermotolerance of malaria parasites. [PDF]

PLoS Pathog
Roper B, Kannan D, Mathews ES, Odom John AR.   +3 more
europepmc   +1 more source

Hyperoxia Induced Alteration of Chromatin Structure in Human Bone Marrow Derived Primary Mesenchymal Stromal Cells

Advanced Biology, EarlyView.
Chromatin, which organizes DNA, changes its structure to adapt to stress like high oxygen levels (hyperoxia), which can damage cells. Researchers developed a technique to observe these changes and found variability in how different parts of chromatin remodel.
Lauren Monroe, Samantha Kaonis, Natalie Calahan, Neda Kabi, Soham Ghosh   +4 more
wiley   +1 more source

De Novo Expressed Vpr Stimulates HIV-1 Replication in T Cells. [PDF]

Viruses
Enya B, Skowronski J.
europepmc   +1 more source

Activation of NF‐κB Signaling by Optogenetic Clustering of IKKα and β

Advanced Biology, EarlyView.
This study presents an optogenetic approach for graded clustering of eGFP‐fused proteins using an eGFP‐specific nanobody and engineered Cryptochrome 2 variants. The method enables potent, reversible activation of NF‐κB signaling via endogenous pathways, as confirmed by RNA sequencing. This versatile system provides a spatially and temporally controlled
Alexandra Anna Maria Fischer, Markus Michael Kramer, Miguel Baños, Merlin Moritz Grimm, Manfred Fliegauf, Bodo Grimbacher, Gerald Radziwill, Sven Rahmann, Wilfried Weber   +8 more
wiley   +1 more source

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

Advanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio, B. Spedicato, G. Corallo, A. Inguscio, M. Greco, D. Musarò, D. Vergara, A. F. Muro, G. De Sabbata, L. R. Soria, N. Brunetti Pierri, M. Maffia   +11 more
wiley   +1 more source