Results 261 to 270 of about 76,259 (304)
The mechanism of checkpoint-dependent DNA replication fork stabilization in human cells
Bertolin AP +6 more
europepmc +1 more source
Some of the next articles are maybe not open access.
Related searches:
Related searches:
Non-replicative helicases at the replication fork
DNA Repair, 2007Reactivation of stalled or collapsed replication forks is an essential process in bacteria. Restart systems operate to restore the 5'-->3' replicative helicase, DnaB, to the lagging-strand template. However, other non-replicative 3'-->5' helicases play an important role in the restart process as well.
Ryan C, Heller, Kenneth J, Marians
openaire +2 more sources
The Stability of Nucleosomes at the Replication Fork
Journal of Molecular Biology, 1996Purified simian virus (SV40) minichromosomes were photoreacted with psoralen under various conditions that moderately destabilize nucleosomes. This assay allows indirect distinction between stable nucleosomes, partially unravelled nucleosomes and nucleosomes containing (or lacking) histone H1.
R, Gasser, T, Koller, J M, Sogo
openaire +2 more sources
Helicases at the Replication Fork
2012Helicases are fundamental components of all replication complexes since unwinding of the double-stranded template to generate single-stranded DNA is essential to direct DNA synthesis by polymerases. However, helicases are also required in many other steps of DNA replication. Replicative helicases not only unwind the template DNA but also play key roles
openaire +2 more sources
Replicative DNA Polymerases and Mechanisms at a Replication Fork
1980Publisher Summary This chapter discusses mechanisms of DNA synthesis at a replication fork, with emphasis on the replicative DNA polymerases. This chapter also compares the properties of some of these enzymes, particularly in relation to processes of strand unwinding, translocation along templates, and accurate incorporation of nucleotides, as well ...
R K, Fujimura, S K, Das
openaire +2 more sources
Probing replication origins with a fork
Trends in Cell Biology, 1991In 1968, Huberman and Riggs used DNA-fibre autoradiography to dem- onstrate that the replication of eukaryotic chromosomes occurs bi- directionally from multiple discrete sites that appear to be irregularly spaced along the chromosome t. Since then, the specific sequence requirements of prokaryotic and viral replication origins have been well ...
openaire +2 more sources
2009
DNA replication is a complex mechanism that functions due to the co-ordinated interplay of several dozen protein factors. In the last few years, numerous studies suggested a tight implication of DNA replication factors in several DNA transaction events that maintain the integrity of the genome.
openaire +4 more sources
DNA replication is a complex mechanism that functions due to the co-ordinated interplay of several dozen protein factors. In the last few years, numerous studies suggested a tight implication of DNA replication factors in several DNA transaction events that maintain the integrity of the genome.
openaire +4 more sources
Organization of the newly replicated chromatin in the vicinity of the replication fork
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 1982Ehrlich ascites tumour cells were pulse-labelled with [3H]thymidine for 1 min or were treated with cycloheximide and labelled with [3H]thymidine for 45 min. The kinetics of digestion with micrococcal nuclease of both pulse-labelled and cycloheximide chromatins showed that they exhibited increased susceptibility towards the enzyme.
V, Pospelov, B, Anachkova, G, Russev
openaire +2 more sources
The battle of replication fork
Journal of Medical Genetics, 2010> Small soldiers march swiftly, the battle draws near > > Helicase from the cannons split legions, no fear > > Commanders ride forth with bellowing calls > > Sending signals to primers, engage, pair them all! > > Deoxy stands back, a path …
openaire +1 more source
Replication forks and replication checkpoints in repair
2007Eukaryotic cells replicate their DNA and coordinate their response to DNA damage and replication blocks by activating appropriate repair processes, regulating recombination, chromatin assembly and chromosome partitioning. Replication forks stall at specific problematic genomic regions, and forks collapse unless protected by replication checkpoint ...
Dana Branzei, Marco Foiani
openaire +1 more source