Results 141 to 150 of about 260,016 (217)

DABPU-DE targeting host adipose triglyceride lipase provides broad-spectrum anti-coronavirus effects <i>in vitro</i>. [PDF]

Front Pharmacol
Farouk R, Lee DJ, Aboelmagd S, Kwon HJ, Jeong SH, Han SI, Cheong DE, Ny S, Seo HR, Lee C, Kim E, Lee S, Cho KO.   +12 more
europepmc   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Tumour-based DNA methylation markers of breast cancer survival: a pooled analysis of 2157 cases. [PDF]

Breast Cancer Res
Zarean E, Li S, Makalic E, Milne RL, Giles GG, McLean C, Southey MC, Dugué PA.   +7 more
europepmc   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Can synthetic data reproduce real-world findings in epidemiology? A replication study using adversarial random forests. [PDF]

Int J Epidemiol
Kapar J, Günther K, Vallis LA, Berger K, Binder N, Brenner H, Castell S, Fischer B, Harth V, Holleczek B, Intemann T, Ittermann T, Karch A, Keil T, Krist L, Lange B, Leitzmann MF, Nimptsch K, Obi N, Pigeot I, Pischon T, Schikowski T, Schmidt B, Schmidt CO, Sedlmair AM, Tanoey J, Wienbergen H, Wienke A, Wigmann C, Wright MN.   +29 more
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Anti-RSV drug screening and inhibition of RSV infection by lapatinib through the IL-17 pathway. [PDF]

Antimicrob Agents Chemother
Sun Z, Huang Y, Guo R, Jiang T, Chen Q, Zhang X, Liu J, Tang Q, Chen M, Huang S.   +9 more
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

The Mechanism of Monolaurate Derived Glycolipids Inhibit Sindbis Virus Replication and Release. [PDF]

J Med Virol
Lu JW, Helal M, Lee GC, Liu CH, Liu FC, Lin TC, Peng WZ, Ho YJ.   +7 more
europepmc   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source