Results 91 to 100 of about 3,588,418 (239)
Frontiers in Microbiology, 2020 Faithful DNA replication is crucial for viability of cells across all kingdoms. Targeting DNA replication is a viable strategy for inhibition of bacterial pathogens.
Ana M. Oliveira Paiva +6 more
doaj +1 more source
“Update vision on COVID-19: Structure, immune pathogenesis, treatment and safety assessment”
Sensors International, 2021 The on-going SARS-CoV-2 causing COVID-19 discovered in December 2019, is responsible for a global pandemic. The virus belongs to the group of enveloped viruses containing linear, non-segmented, single stranded, positive sense strand RNA as genetic ...
Rishabh Agrahari +5 more
doaj +1 more source
Molecules and Cells, 2015 Eukaryotic replication initiation is highly regulated and dynamic. It begins with the origin recognition complex (ORC) binding DNA sites called origins of replication. ORC, together with Cdc6 and Cdt1, mediate pre-replicative complex (pre-RC) assembly by
D. Duzdevich +5 more
semanticscholar +1 more source
Evidence for symmetric chromosomal inversions around the replication origin in bacteria. [PDF]
, 2000 BackgroundWhole-genome comparisons can provide great insight into many aspects of biology. Until recently, however, comparisons were mainly possible only between distantly related species.
Eisen, JA +3 more
core +1 more source
Diverged composition and regulation of the Trypanosoma brucei origin recognition complex that mediates DNA replication initiation [PDF]
, 2016 Initiation of DNA replication depends upon recognition of genomic sites, termed origins, by AAA+ ATPases. In prokaryotes a single factor binds each origin, whereas in eukaryotes this role is played by a six-protein origin recognition complex (ORC).
Damasceno, Jeziel D. +7 more
core +3 more sources
Epigenetic Control of Replication Origins [PDF]
Cell Cycle, 2005 Efficient duplication of the eukaryotic genome requires the spatial and temporal coordination of numerous replication origins on each chromosome. Epigenetic factors, like chromatin environment, can have profound effects on origin site selection, utilization frequency, and cell cycle firing time.
Jing, Zhou +4 more
openaire +2 more sources
On the origins and variation of nucleotide skews of archaeal genomes
Frontiers in MicrobiologyWe have used nucleotide skews as the proxy to understand the evolution of archaeal genomes. Our genome-wide studies using substantial datasets suggest that translational selection and the nature of the genetic code are universally conserved determinants ...
Adrien Paravel +6 more
doaj +1 more source
ATPase-Dependent Quality Control of DNA Replication Origin Licensing
Nature, 2013 The regulated loading of the Mcm2–7 DNA helicase (comprising six related subunits, Mcm2 to Mcm7) into pre-replicative complexes at multiple replication origins ensures precise once per cell cycle replication in eukaryotic cells.
J. Frigola +3 more
semanticscholar +1 more source
Replication forks, chromatin loops and dormant replication origins [PDF]
Genome Biology, 2008 When DNA replication is slowed down, normally dormant replication origins are activated. Recent work demonstrates that cells adapt by changing the organization of chromatin loops and maintaining the new pattern of origin use in subsequent cell cycles.
Blow, J. Julian, Ge, Xin Q
openaire +3 more sources
Activation of mammalian Chk1 during DNA replication arrest: a role for Chk1 in the intra-S phase checkpoint monitoring replication origin firing [PDF]
, 2001 Checkpoints maintain order and fidelity in the cell cycle by blocking late-occurring events when earlier events are improperly executed. Here we describe evidence for the participation of Chk1 in an intra-S phase checkpoint in mammalian cells.
Feijoo, Carmen +6 more
core +2 more sources