Results 61 to 70 of about 3,588,418 (239)

Regulated Eukaryotic DNA Replication Origin Firing with Purified Proteins

Nature, 2015
Eukaryotic cells initiate DNA replication from multiple origins, which must be tightly regulated to promote precise genome duplication in every cell cycle.
Joseph T. P. Yeeles, T. Deegan, Agnieszka Janska, A. Early, J. Diffley   +4 more
semanticscholar   +1 more source

The dynamics of replication licensing in live Caenorhabditis elegans embryos [PDF]

, 2012
Accurate DNA replication requires proper regulation of replication licensing, which entails loading MCM-2-7 onto replication origins. In this paper, we provide the first comprehensive view of replication licensing in vivo, using video microscopy of ...
Anton Gartner, Ashley Craig, Baldinger, Blow, Blow, Brauchle, Brenner, Cheeseman, Chen, Clarey, Clarey, DePamphilis, Drury, Edgar, Encalada, Evrin, Galy, Gambus, Gillespie, Hadwiger, Harvey, Ilves, J. Julian Blow, Kamath, Kim, Kisielewska, Korzelius, Kuipers, Li, Li, Li, Liu, Matthieu Querenet, McNairn, McNally, Moyer, Oehlmann, Praitis, Prokhorova, Quinn, Randell, Remi Sonneville, Remus, Rothbauer, Rowles, Shelton, Siddiqui, Speck, Sönnichsen, Tada, Timmons, Waga, Wallenfang, Wohlschlegel, Yanagi, Yang, Zhong   +56 more
core   +4 more sources

Universal temporal profile of replication origin activation in eukaryotes. [PDF]

PLoS ONE, 2009
Although replication proteins are conserved among eukaryotes, the sequence requirements for replication initiation differ between species. In all species, however, replication origins fire asynchronously throughout S phase. The temporal program of origin
Arach Goldar, Marie-Claude Marsolier-Kergoat, Olivier Hyrien   +2 more
doaj   +1 more source

Avoiding chromosome pathology when replication forks collide [PDF]

, 2013
This is the author's accepted manuscript. The final published article is available from the link below. Copyright @ 2013 Macmillan Publishers Limited.Chromosome duplication normally initiates through the assembly of replication fork complexes at defined ...
Lloyd, RG, Nieduszynski, CA, Stockum, A, Upton, AL   +3 more
core   +1 more source

Origins of DNA replication

PLOS Genetics, 2019
In all kingdoms of life, DNA is used to encode hereditary information. Propagation of the genetic material between generations requires timely and accurate duplication of DNA by semiconservative replication prior to cell division to ensure each daughter cell receives the full complement of chromosomes.
Babatunde Ekundayo, Franziska Bleichert
openaire   +4 more sources

Identification of 1600 replication origins in S. cerevisiae

eLife
There are approximately 500 known origins of replication in the yeast genome, and the process by which DNA replication initiates at these locations is well understood.
Eric J Foss, Carmina Lichauco, Tonibelle Gatbonton-Schwager, Sara J Gonske, Brandon Lofts, Uyen Lao, Antonio Bedalov   +6 more
doaj   +1 more source

The chromatin environment shapes DNA replication origin organization and defines origin classes

Genome Research, 2015
To unveil the still-elusive nature of metazoan replication origins, we identified them genome-wide and at unprecedented high-resolution in mouse ES cells. This allowed initiation sites (IS) and initiation zones (IZ) to be differentiated.
Christelle Cayrou, B. Ballester, I. Peiffer, Romain Fenouil, P. Coulombe, J. Andrau, J. van Helden, M. Méchali   +7 more
semanticscholar   +1 more source

Interaction of RECQ4 and MCM10 is important for efficient DNA replication origin firing in human cells

OncoTarget, 2015
DNA replication is a highly coordinated process that is initiated at multiple replication origins in eukaryotes. These origins are bound by the origin recognition complex (ORC), which subsequently recruits the Mcm2-7 replicative helicase in a Cdt1/Cdc6 ...
Maciej Kliszczak, Hana Sedlackova, G. Pitchai, Werner W. Streicher, L. Krejci, I. Hickson   +5 more
semanticscholar   +1 more source

The bovine papillomavirus origin of replication requires a binding site for the E2 transcriptional activator [PDF]

, 1993
The bovine papillomavirus type I transcriptional activator E2 is essential for replication of bovine papillomavirus DNA, yet most of the high-affinity binding sites for E2 are dispensable.
Ustav, E., Ustav, M., Szymanski, P., Stenlund, A.   +3 more
core   +1 more source

New stopping criteria for segmenting DNA sequences [PDF]

, 2001
We propose a solution on the stopping criterion in segmenting inhomogeneous DNA sequences with complex statistical patterns. This new stopping criterion is based on Bayesian Information Criterion (BIC) in the model selection framework. When this stopping
A. Audit, A. E. Raftery, A. W. F. Edwards, B. James, C. K. Peng, F. R. Blattner, G. Bernardi, G. K. Zipf, G. Schwartz, H. Jeffreys, J. L. Oliver, J. Lin, J. V. Braum, K. P. Burnham, M. Johnson, M. V. Olson, P. Bernaola-Galván, P. Bernaola-Galván, P. Carpena, P. L. Krapivsky, R. F. Voss, R. Román-Roldán, S. Redney, V. E. Ramensky, W. Li, W. Li, W. Li, W. Li, W. Li, W. Li, Wentian Li   +30 more
core   +2 more sources