Results 71 to 80 of about 3,588,418 (239)

Comprehensive Analysis of Replication Origins in Saccharomyces cerevisiae Genomes

Frontiers in Microbiology, 2019
DNA replication initiates from multiple replication origins (ORIs) in eukaryotes. Discovery and characterization of replication origins are essential for a better understanding of the molecular mechanism of DNA replication. In this study, the features of
Dan Wang, Feng Gao, Feng Gao, Feng Gao
doaj   +1 more source

H3K4me3 demethylation by the histone demethylase KDM5C/JARID1C promotes DNA replication origin firing

Nucleic Acids Research, 2015
DNA replication is a tightly regulated process that initiates from multiple replication origins and leads to the faithful transmission of the genetic material. For proper DNA replication, the chromatin surrounding origins needs to be remodeled.
B. Rondinelli, H. Schwerer, Elena Antonini, M. Gaviraghi, Alessio Lupi, M. Frenquelli, Davide Cittaro, S. Segalla, J. Lemaître, G. Tonon   +9 more
semanticscholar   +1 more source

A quantitative model of the initiation of DNA replication in Saccharomyces cerevisiae predicts the effects of system perturbations. [PDF]

, 2012
BackgroundEukaryotic cell proliferation involves DNA replication, a tightly regulated process mediated by a multitude of protein factors. In budding yeast, the initiation of replication is facilitated by the heterohexameric origin recognition complex ...
DaSilva, Lance F, Duncker, Bernard P, Gidvani, Rohan D, Ingalls, Brian P, Li, Grace, McConkey, Brendan J, Sudmant, Peter   +6 more
core   +3 more sources

Primosomal protein PriC rescues replication initiation stress by bypassing the DnaA-DnaB interaction step for DnaB helicase loading at oriC

eLife
In Escherichia coli, replisome and replication fork assembly is initiated by DnaB helicase loading at the chromosomal origin oriC via its interactions with the DnaA initiator and the DnaC helicase loader.
Ryusei Yoshida, Kazuma Korogi, Qinfei Wu, Shogo Ozaki, Tsutomu Katayama   +4 more
doaj   +1 more source

SIRT1 Deacetylates TopBP1 and Modulates Intra-S-Phase Checkpoint and DNA Replication Origin Firing

International Journal on Biological Sciences, 2014
SIRT1, the mammalian homolog of yeast Sir2, is a founding member of a family of 7 protein and histone deacetylases that are involved in numerous biological functions.
Ruihong Wang, T. Lahusen, Qiang Chen, Xiaoling Xu, L. Jenkins, Elisabetta Leo, Haiqing Fu, M. Aladjem, Y. Pommier, E. Appella, C. Deng   +10 more
semanticscholar   +1 more source

Horizontal transfer between loose compartments stabilizes replication of fragmented ribozymes

, 2019
The emergence of replicases that can replicate themselves is a central issue in the origin of life. Recent experiments suggest that such replicases can be realized if an RNA polymerase ribozyme is divided into fragments short enough to be replicable by ...
Kamimura, Atsushi, Kaneko, Kunihiko, Matsubara, Yoshiya J., Takeuchi, Nobuto   +3 more
core   +2 more sources

A back-up mechanism for replication

eLife
A protein called PriC allows DNA replication to proceed in Escherichia coli when the complex that usually initiates this process is compromised.
Godefroid Charbon, Anders Løbner-Olesen
doaj   +1 more source

Protein Phosphatase 1 Recruitment by Rif1 Regulates DNA Replication Origin Firing by Counteracting DDK Activity

Cell Reports, 2014
Summary The firing of eukaryotic origins of DNA replication requires CDK and DDK kinase activities. DDK, in particular, is involved in setting the temporal program of origin activation, a conserved feature of eukaryotes.
Anoushka Davé, Carol Cooley, M. Garg, A. Bianchi   +3 more
semanticscholar   +1 more source

Mechanosensitive Self-Replication Driven by Self-Organization [PDF]

, 2010
Self-replicating molecules are likely to have played an important role in the origin of life, and a small number of fully synthetic self-replicators have already been described.
Belenguer, Ana M.,, Carnall, Jacqui M.A.,, Otto, Sijbren,, Peyralans, Jérôme J.-P.,, Stuart, Marc C.A.,, Waudby, Christopher A.,   +5 more
core   +3 more sources

Chromosome I controls chromosome II replication in Vibrio cholerae.

PLoS Genetics, 2014
Control of chromosome replication involves a common set of regulators in eukaryotes, whereas bacteria with divided genomes use chromosome-specific regulators. How bacterial chromosomes might communicate for replication is not known.
Jong Hwan Baek, Dhruba K Chattoraj
doaj   +1 more source