Results 61 to 70 of about 1,971,949 (299)
A hybrid bacterial replication origin [PDF]
The EMBO Reports, 2001 We constructed a hybrid replication origin that consists of the main part of oriC from Escherichia coli, the DnaA box region and the AT-rich region from Bacillus subtilis oriC. The AT-rich region could be unwound by E. coli DnaA protein, and the DnaB helicase was loaded into the single-stranded bubble.
H, Seitz, M, Welzeck, W, Messer
openaire +2 more sources
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
On the origins and variation of nucleotide skews of archaeal genomes
Frontiers in MicrobiologyWe have used nucleotide skews as the proxy to understand the evolution of archaeal genomes. Our genome-wide studies using substantial datasets suggest that translational selection and the nature of the genetic code are universally conserved determinants ...
Adrien Paravel +6 more
doaj +1 more source
Functional characterization of the origin of replication of pRN1 from Sulfolobus islandicus REN1H1. [PDF]
PLoS ONE, 2013 Plasmid pRN1 from Sulfolobus islandicus REN1H1 is believed to replicate by a rolling circle mechanism but its origin and mechanism of replication are not well understood.
Chijioke J Joshua +2 more
doaj +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Frontiers in Microbiology, 2020 Faithful DNA replication is crucial for viability of cells across all kingdoms. Targeting DNA replication is a viable strategy for inhibition of bacterial pathogens.
Ana M. Oliveira Paiva +6 more
doaj +1 more source
“Update vision on COVID-19: Structure, immune pathogenesis, treatment and safety assessment”
Sensors International, 2021 The on-going SARS-CoV-2 causing COVID-19 discovered in December 2019, is responsible for a global pandemic. The virus belongs to the group of enveloped viruses containing linear, non-segmented, single stranded, positive sense strand RNA as genetic ...
Rishabh Agrahari +5 more
doaj +1 more source
Metazoan DNA replication origins [PDF]
Current Opinion in Cell Biology, 2019 DNA replication starts with the opening of DNA at sites called DNA replication origins. From the single sequence-specific DNA replication origin of the small Escherichia coli genome, up to thousands of origins that are necessary to replicate the large human genome, strict sequence specificity has been lost.
Olivier, Ganier +3 more
openaire +2 more sources
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
The role of protein kinases in DNA replication in Saccharomyces cerevisiae [PDF]
, 2010 The initiation of DNA replication at the onset of S phase in eukaryotic cells is a critically important and tightly regulated process. Multiple origins of replication in the genome must be co-ordinately regulated such that duplication of the chromosomes ...
Sweet, S.
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