DNA replication initiation factor RECQ4 possesses a role in antagonizing DNA replication initiation [PDF]
Nature Communications, 2023 RECQ4 mutations contribute to multiple developmental diseases and tumorigenesis. Here the authors describe how a highly oncogenic RECQ4 mutation alters the control of DNA synthesis, leading to abnormal DNA content and cell growth.
Xiaohua Xu +7 more
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Control of DNA Replication Initiation by Ubiquitin [PDF]
Cells, 2018 Eukaryotic cells divide by accomplishing a program of events in which the replication of the genome is a fundamental part. To ensure all cells have an accurate copy of the genome, DNA replication occurs only once per cell cycle and is controlled by ...
Esperanza Hernández-Carralero +5 more
doaj +5 more sources
DNA replication initiation timing is important for maintaining genome integrity [PDF]
Journal of BacteriologyDNA replication is regulated by factors that promote or inhibit initiation. In Bacillus subtilis, YabA is a negative regulator of replication initiation, while the newly identified kinase CcrZ is a positive regulator. The consequences of under-initiation
Tristan T. Reed +3 more
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Most human DNA replication initiation is dispersed throughout the genome with only a minority within previously identified initiation zones [PDF]
Genome BiologyBackground The identification of sites of DNA replication initiation in mammalian cells has been challenging. Here, we present unbiased detection of replication initiation events in human cells using BrdU incorporation and single-molecule nanopore ...
Jamie T. Carrington +10 more
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Primosomal protein PriC rescues replication initiation stress by bypassing the DnaA-DnaB interaction step for DnaB helicase loading at oriC [PDF]
eLifeIn Escherichia coli, replisome and replication fork assembly is initiated by DnaB helicase loading at the chromosomal origin oriC via its interactions with the DnaA initiator and the DnaC helicase loader.
Ryusei Yoshida +4 more
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The iron-sulfur accelerator YgfZ modulates genome-wide IHF-binding dynamics to regulate replication initiation in Escherichia coli [PDF]
Frontiers in MicrobiologyIn Escherichia coli, chromosome replication is regulated through ATP/ADP state of the DnaA initiator. The DDAH system inactivates DnaA in the post-initiation stage by promoting ATP hydrolysis through timely binding of the DNA-bending protein IHF to the ...
Kazutoshi Kasho +7 more
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DNA replication initiation drives focal mutagenesis and rearrangements in human cancers [PDF]
Nature CommunicationsThe rate and pattern of mutagenesis in cancer genomes is significantly influenced by DNA accessibility and active biological processes. Here we show that efficient sites of replication initiation drive and modulate specific mutational processes in cancer.
Pierre Murat +2 more
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The non-catalytic role of DNA polymerase epsilon in replication initiation in human cells [PDF]
Nature Communications, 2022 DNA polymerase epsilon has a critical role in DNA replication initiation. Here, the authors show that in human cancer cells POLE is dispensable for the replicative helicase assembly but not for replication initiation, which requires the non-catalytic ...
Sameera Vipat +5 more
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Single-molecule imaging reveals the mechanism of bidirectional replication initiation in metazoa [PDF]
CellRiki Terui, Gheorghe Chistol
exaly +2 more sources
Initiation of DNA Replication [PDF]
EcoSal Plus, 2010 In recent years it has become clear that complex regulatory circuits control the initiation step of DNA replication by directing the assembly of a multicomponent molecular machine (the orisome) that separates DNA strands and loads replicative helicase at oriC , the unique chromosomal origin of replication.
Alan C, Leonard, Julia E, Grimwade
openaire +2 more sources