Control of DNA Replication Initiation by Ubiquitin [PDF]
Cells, 2018 Eukaryotic cells divide by accomplishing a program of events in which the replication of the genome is a fundamental part. To ensure all cells have an accurate copy of the genome, DNA replication occurs only once per cell cycle and is controlled by ...
Esperanza Hernández-Carralero +5 more
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DNA replication initiation factor RECQ4 possesses a role in antagonizing DNA replication initiation [PDF]
Nature Communications, 2023 RECQ4 mutations contribute to multiple developmental diseases and tumorigenesis. Here the authors describe how a highly oncogenic RECQ4 mutation alters the control of DNA synthesis, leading to abnormal DNA content and cell growth.
Xiaohua Xu +7 more
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Transcription shapes DNA replication initiation to preserve genome integrity [PDF]
Genome Biology, 2021 Background Early DNA replication occurs within actively transcribed chromatin compartments in mammalian cells, raising the immediate question of how early DNA replication coordinates with transcription to avoid collisions and DNA damage.
Yang Liu +10 more
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DNA replication initiation timing is important for maintaining genome integrity [PDF]
Journal of BacteriologyDNA replication is regulated by factors that promote or inhibit initiation. In Bacillus subtilis, YabA is a negative regulator of replication initiation, while the newly identified kinase CcrZ is a positive regulator. The consequences of under-initiation
Tristan T. Reed +3 more
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Most human DNA replication initiation is dispersed throughout the genome with only a minority within previously identified initiation zones [PDF]
Genome BiologyBackground The identification of sites of DNA replication initiation in mammalian cells has been challenging. Here, we present unbiased detection of replication initiation events in human cells using BrdU incorporation and single-molecule nanopore ...
Jamie T. Carrington +10 more
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The Stringent Response Inhibits DNA Replication Initiation in
mBio, 2019 The stringent response enables bacteria to respond to a variety of environmental stresses, especially various forms of nutrient limitation. During the stringent response, the cell produces large quantities of the nucleotide alarmone ppGpp, which ...
James A. Kraemer +2 more
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DNA replication initiation drives focal mutagenesis and rearrangements in human cancers [PDF]
Nature CommunicationsThe rate and pattern of mutagenesis in cancer genomes is significantly influenced by DNA accessibility and active biological processes. Here we show that efficient sites of replication initiation drive and modulate specific mutational processes in cancer.
Pierre Murat +2 more
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Investigating the role of Rts1 in DNA replication initiation [version 1; referees: 2 approved] [PDF]
Wellcome Open Research, 2018 Background: Understanding DNA replication initiation is essential to understand the mis-regulation of replication seen in cancer and other human disorders. DNA replication initiates from DNA replication origins. In eukaryotes, replication is dependent on
Ana B.A. Wallis, Conrad A. Nieduszynski
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Laboratory Evolution Experiments Help Identify a Predominant Region of Constitutive Stable DNA Replication Initiation [PDF]
mSphere, 2020 The bacterium Escherichia coli can initiate replication in the absence of the replication initiator protein DnaA and/or the canonical origin of replication oriC in a ΔrnhA background.
Reshma T. Veetil +3 more
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Cooperation between two modes for DNA replication initiation in the archaeon Thermococcus barophilus [PDF]
mBioThe mechanisms underpinning the replication of genomic DNA have recently been challenged in Archaea. Indeed, the lack of origin of replication has no deleterious effect on growth, suggesting that replication initiation relies on homologous recombination.
Logan Mc Teer +13 more
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