Results 31 to 40 of about 178,865 (248)

Cell size and the initiation of DNA replication in bacteria. [PDF]

PLoS Genetics, 2012
In eukaryotes, DNA replication is coupled to the cell cycle through the actions of cyclin-dependent kinases and associated factors. In bacteria, the prevailing view, based primarily from work in Escherichia coli, is that growth-dependent accumulation of ...
Norbert S Hill, Ryosuke Kadoya, Dhruba K Chattoraj, Petra Anne Levin   +3 more
doaj   +1 more source

RNase H1 directs origin-specific initiation of DNA replication in human mitochondria.

PLoS Genetics, 2019
Human mitochondrial DNA (mtDNA) replication is first initiated at the origin of H-strand replication. The initiation depends on RNA primers generated by transcription from an upstream promoter (LSP).
Viktor Posse, Ali Al-Behadili, Jay P Uhler, Anders R Clausen, Aurelio Reyes, Massimo Zeviani, Maria Falkenberg, Claes M Gustafsson   +7 more
doaj   +1 more source

Plasticity of DNA replication initiation in Epstein-Barr virus episomes. [PDF]

PLoS Biology, 2004
In mammalian cells, the activity of the sites of initiation of DNA replication appears to be influenced epigenetically, but this regulation is not fully understood.
Paolo Norio, Carl L Schildkraut
doaj   +1 more source

The initiation of mitochondrial DNA replication

Biochemical Society Transactions
Mitochondrial DNA replication is initiated by the transcription of mitochondrial RNA polymerase (mtRNAP), as mitochondria lack a dedicated primase. However, the mechanism determining the switch between continuous transcription and premature termination to generate RNA primers for mitochondrial DNA (mtDNA) replication remains unclear.
Yi Liu, Haibin Liu, Fan Zhang, Hong Xu
openaire   +2 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Leishmania major chromosomes are replicated from a single high-efficiency locus supplemented by thousands of lower efficiency initiation events

Cell Reports
Summary: DNA replication initiates at genome sites termed origins. Previous origin mapping approaches in the populations of the protozoan parasite Leishmania major were discordant, suggesting either a single origin per chromosome or 200-fold more origins.
Jeziel D. Damasceno, Gabriel L.A. Silva, Catarina A. Marques, Marija Krasilnikova, Craig Lapsley, Dario Beraldi, Richard McCulloch   +6 more
doaj   +1 more source

Genome Replication in Thermococcus kodakarensis Independent of Cdc6 and an Origin of Replication

Frontiers in Microbiology, 2017
The initiation of DNA replication is typically tightly regulated by proteins that form initiation complexes at specific sequences known as replication origins.
Alexandra M. Gehring, David P. Astling, Rie Matsumi, Brett W. Burkhart, Zvi Kelman, John N. Reeve, Kenneth L. Jones, Thomas J. Santangelo   +7 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Studies on the Initiation of Plasmid DNA Replication [PDF]

European Journal of Biochemistry, 1974
The replication of the bacterial plasmids is dependent on two chromosome‐determined products (dnaA and dnaC), which are involved in the initiation of the chromosomal DNA synthesis of Escherichia coli. The inhibition of Col E1 DNA synthesis in a dnaA‐mutant (CRT 46) at the restrictive temperature, is eliminated by the addition of low doses of ...
openaire   +2 more sources