Results 31 to 40 of about 188,643 (203)
Genome Replication in Thermococcus kodakarensis Independent of Cdc6 and an Origin of Replication
Frontiers in Microbiology, 2017 The initiation of DNA replication is typically tightly regulated by proteins that form initiation complexes at specific sequences known as replication origins.
Alexandra M. Gehring +7 more
doaj +1 more source
Dynamics of replication origin over-activation
Nature Communications, 2021 DNA replication processes are often dysregulated in cancer. Here the authors analyse DNA synthesis patterns in cancer cells undergoing partial genome re-replication to reveal that re-replication exhibits aberrant replication fork dynamics and a skewed ...
Haiqing Fu +15 more
doaj +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
Plasticity of DNA replication initiation in Epstein-Barr virus episomes. [PDF]
PLoS Biology, 2004 In mammalian cells, the activity of the sites of initiation of DNA replication appears to be influenced epigenetically, but this regulation is not fully understood.
Paolo Norio, Carl L Schildkraut
doaj +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Identification of 1600 replication origins in S. cerevisiae
eLifeThere are approximately 500 known origins of replication in the yeast genome, and the process by which DNA replication initiates at these locations is well understood.
Eric J Foss +6 more
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
DNA Replication in Time and Space: The Archaeal Dimension
DNAThe ability of a nucleic acid molecule to self-replicate is the driving force behind the evolution of cellular life and the transition from RNA to DNA as the genetic material.
Anastasia Serdyuk, Thorsten Allers
doaj +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Extrusion-modulated DnaA activity oscillations coordinate DNA replication with biomass growth
eLifeRobust control of DNA replication is fundamental to bacterial proliferation. In Escherichia coli, replication initiation is thought to be regulated by oscillations in DnaA activity, driven by DnaA-chromosome interactions that differ among leading models.
Dengjin Li +10 more
doaj +1 more source