Results 21 to 30 of about 178,865 (248)
Biomedicines, 2022 Precise regulation of DNA replication complex assembly requires cyclin-dependent kinase (CDK) and Dbf4-dependent kinase (DDK) activities to activate the replicative helicase complex and initiate DNA replication. Chemical probes have been essential in the
Tekle Pauzaite +8 more
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G-quadruplexes of KSHV oriLyt play important roles in promoting lytic DNA replication
Microbiology Spectrum, 2023 Kaposi’s sarcoma-associated herpesvirus (KSHV) utilizes distinct origins of DNA replication (origin of replications) during the latent and lytic phases of its life cycle.
Prerna Dabral +2 more
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The interaction networks of the budding yeast and human DNA replication-initiation proteins. [PDF]
Cell Cycle, 2019 Wu R +7 more
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Origins and complexes: the initiation of DNA replication [PDF]
Journal of Experimental Botany, 2001 Eukaryotic DNA is organized for replication as multiple replicons. DNA synthesis in each replicon is initiated at an origin of replication. In both budding yeast, Saccharomyces cerevisiae and fission yeast, Schizosaccharomyces pombe, origins contain specific sequences that are essential for initiation, although these differ significantly between the ...
J A, Bryant, K, Moore, S J, Aves
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Research, 2022 DNA replication initiation is a complex process involving various genetic and epigenomic signatures. The correct identification of replication origins (ORIs) could provide important clues for the study of a variety of diseases caused by replication. Here,
Fu-Ying Dao +3 more
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PLoS ONE, 2012 Although HCMV encodes many genes required for the replication of its DNA genome, no HCMV-encoded orthologue of the origin binding protein, which has been identified in other herpesviruses, has been identified.
Tamara Evans Braun +2 more
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Dynamics of replication origin over-activation
Nature Communications, 2021 DNA replication processes are often dysregulated in cancer. Here the authors analyse DNA synthesis patterns in cancer cells undergoing partial genome re-replication to reveal that re-replication exhibits aberrant replication fork dynamics and a skewed ...
Haiqing Fu +15 more
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Cell Reports, 2017 Dbf4-dependent kinases (DDKs) are required for the initiation of DNA replication, their essential targets being the MCM2-7 proteins. We show that, in Xenopus laevis egg extracts and human cells, hyper-phosphorylation of DNA-bound Mcm4, but not ...
Robert C. Alver +3 more
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Insights into the Initiation of Eukaryotic DNA Replication [PDF]
Nucleus, 2015 The initiation of DNA replication is a highly regulated event in eukaryotic cells to ensure that the entire genome is copied once and only once during S phase. The primary target of cellular regulation of eukaryotic DNA replication initiation is the assembly and activation of the replication fork helicase, the 11-subunit assembly that unwinds DNA at a ...
Irina, Bruck +3 more
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