Extrusion-modulated DnaA activity oscillations coordinate DNA replication with biomass growth [PDF]
eLifeRobust control of DNA replication is fundamental to bacterial proliferation. In Escherichia coli, replication initiation is thought to be regulated by oscillations in DnaA activity, driven by DnaA-chromosome interactions that differ among leading models.
Dengjin Li +10 more
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Regulation of the activity of the dual-function DnaA protein in Caulobacter crescentus. [PDF]
PLoS ONE, 2011 DnaA is a conserved essential bacterial protein that acts as the initiator of chromosomal replication as well as a master transcriptional regulator in Caulobacter crescentus.
Carmen Fernandez-Fernandez +2 more
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Transcriptional Activity of the Bacterial Replication Initiator DnaA
Frontiers in Microbiology, 2021 In bacteria, DnaA is the most conserved DNA replication initiator protein. DnaA is a DNA binding protein that is part of the AAA+ ATPase family. In addition to initiating chromosome replication, DnaA can also function as a transcription factor either as ...
Paola E Mera
exaly +3 more sources
In Vitro Whole Genome DNA Binding Analysis of the Bacterial Replication Initiator and Transcription Factor DnaA. [PDF]
PLoS Genetics, 2015 DnaA, the replication initiation protein in bacteria, is an AAA+ ATPase that binds and hydrolyzes ATP and exists in a heterogeneous population of ATP-DnaA and ADP-DnaA.
Janet L Smith, Alan D Grossman
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DnaA binding to oriCII regulates transcription from Pseudomonas aeruginosa gidAB-parAB locus linked to the chromosome segregation and streptomycin resistance [PDF]
Scientific ReportsIn many bacteria, the DnaA protein, responsible for chromosome replication initiation, also acts as a transcription factor regulating its own gene expression and the expression of other loci.
Pawel Wawrzyniak +5 more
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The Escherichia coli replication initiator DnaA is titrated on the chromosome [PDF]
Nature CommunicationsDNA replication initiation is orchestrated in bacteria by the replication initiator DnaA. Two models for regulation of DnaA activity in Escherichia coli have been proposed: the switch between an active and inactive form, and the titration of DnaA on the ...
Lorenzo Olivi +9 more
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A Comprehensive In-Silico Pipeline for the Discovery of Non-toxic, Stable Antimicrobial Peptides From Databases for Targeting Multi-Drug Resistant [PDF]
Bioinformatics and Biology InsightsThe rapid emergence of multidrug-resistant Klebsiella pneumoniae has significantly reduced the effectiveness of conventional antibiotics, highlighting the need for alternative therapeutic strategies. This study employed a comprehensive in silico pipeline
Pranab Dev Sharma +6 more
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An antisense RNA regulates production of DnaA and affects sporulation in Bacillus subtilis. [PDF]
PLoS GeneticsDnaA is the replication initiator and a transcription factor in virtually all bacteria. Although the synthesis and activity of DnaA are highly regulated, the mechanisms of regulation vary between organisms.
Emma L Sedivy +2 more
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A novel membrane stress response that blocks chromosomal replication by targeting the DnaA initiator via the ClpP protease [PDF]
Journal of BacteriologyIn Escherichia coli, membrane stress due to interrupted lipoprotein (Lpp) maturation impairs DNA replication and arrests cell growth. How Lpp maturation and DNA replication are connected remains unclear.
Alabi Gbolahan +8 more
doaj +2 more sources
Inactivation of Individual SeqA Binding Sites of the E. coli Origin Reveals Robustness of Replication Initiation Synchrony. [PDF]
PLoS ONE, 2016 The Escherichia coli origin of replication, oriC, comprises mostly binding sites of two proteins: DnaA, a positive regulator, and SeqA, a negative regulator.
Jyoti K Jha, Dhruba K Chattoraj
doaj +1 more source