Frontiers in Microbiology, 2018 More than 50 years have passed since the presentation of the Replicon Model which states that a positively acting initiator interacts with a specific site on a circular chromosome molecule to initiate DNA replication. Since then, the origin of chromosome
Flemming G Hansen +2 more
exaly +10 more sources
Unique and universal features of Epsilonproteobacterial origins of chromosome replication and DnaA-DnaA box interactions [PDF]
Frontiers in Microbiology, 2016 In bacteria, chromosome replication is initiated by the interaction of the initiator protein DnaA with a defined region of a chromosome at which DNA replication starts (oriC).
Pawel Jaworski +6 more
doaj +7 more sources
The DnaA Cycle in Escherichia coli: Activation, Function and Inactivation of the Initiator Protein
Frontiers in Microbiology, 2017 This review summarizes the mechanisms of the initiator protein DnaA in replication initiation and its regulation in Escherichia coli. The chromosomal origin (oriC) DNA is unwound by the replication initiation complex to allow loading of DnaB helicases ...
Tsutomu Katayama +2 more
exaly +4 more sources
Modulation of pPS10 host range by DnaA [PDF]
Molecular Microbiology, 2002 SummaryNarrow‐host‐range plasmid pPS10, originally found inPseudomonas savastanoi, is unable to replicate in other strains such asEscherichia coli. Here, we report that the establishment of pPS10 inE. colican be achieved by a triple mutation in thednaAgene ofE.
Maestro, Beatriz +5 more
core +7 more sources
Extrusion-modulated DnaA activity oscillations coordinate DNA replication with biomass growth [PDF]
eLifeRobust control of DNA replication is fundamental to bacterial proliferation. In Escherichia coli, replication initiation is thought to be regulated by oscillations in DnaA activity, driven by DnaA-chromosome interactions that differ among leading models.
Dengjin Li +10 more
doaj +2 more sources
Regulation of the activity of the dual-function DnaA protein in Caulobacter crescentus. [PDF]
PLoS ONE, 2011 DnaA is a conserved essential bacterial protein that acts as the initiator of chromosomal replication as well as a master transcriptional regulator in Caulobacter crescentus.
Carmen Fernandez-Fernandez +2 more
doaj +2 more sources
Transcriptional Activity of the Bacterial Replication Initiator DnaA
Frontiers in Microbiology, 2021 In bacteria, DnaA is the most conserved DNA replication initiator protein. DnaA is a DNA binding protein that is part of the AAA+ ATPase family. In addition to initiating chromosome replication, DnaA can also function as a transcription factor either as ...
Paola E Mera
exaly +3 more sources
The Escherichia coli replication initiator DnaA is titrated on the chromosome [PDF]
Nature CommunicationsDNA replication initiation is orchestrated in bacteria by the replication initiator DnaA. Two models for regulation of DnaA activity in Escherichia coli have been proposed: the switch between an active and inactive form, and the titration of DnaA on the ...
Lorenzo Olivi +9 more
doaj +2 more sources
In Vitro Whole Genome DNA Binding Analysis of the Bacterial Replication Initiator and Transcription Factor DnaA. [PDF]
PLoS Genetics, 2015 DnaA, the replication initiation protein in bacteria, is an AAA+ ATPase that binds and hydrolyzes ATP and exists in a heterogeneous population of ATP-DnaA and ADP-DnaA.
Janet L Smith, Alan D Grossman
doaj +3 more sources
An antisense RNA regulates production of DnaA and affects sporulation in Bacillus subtilis. [PDF]
PLoS GeneticsDnaA is the replication initiator and a transcription factor in virtually all bacteria. Although the synthesis and activity of DnaA are highly regulated, the mechanisms of regulation vary between organisms.
Emma L Sedivy +2 more
doaj +2 more sources