Results 31 to 40 of about 8,858 (210)
DnaA and ORC: more than DNA replication initiators [PDF]
Trends in Cell Biology, 2011 Mutations in DNA replication initiator genes in both prokaryotes and eukaryotes lead to a pleiotropic array of phenotypes, including defects in chromosome segregation, cytokinesis, cell cycle regulation and gene expression. For years, it was not clear whether these diverse effects were indirect consequences of perturbed DNA replication, or whether they
Scholefield G, Veening JW, Murray H
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In-vitro helix opening of M. tuberculosis oriC by DnaA occurs at precise location and is inhibited by IciA like protein. [PDF]
PLoS ONE, 2009 BACKGROUND: Mycobacterium tuberculosis (M.tb), the pathogen that causes tuberculosis, is capable of staying asymptomatically in a latent form, persisting for years in very low replicating state, before getting reactivated to cause active infection. It is
Sandeep Kumar +2 more
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Cooperative DnaA Binding to the Negatively Supercoiled datA Locus Stimulates DnaA-ATP Hydrolysis [PDF]
Journal of Biological Chemistry, 2017 Timely initiation of replication in Escherichia coli requires functional regulation of the replication initiator, ATP-DnaA. The cellular level of ATP-DnaA increases just before initiation, after which its level decreases through hydrolysis of DnaA-bound ATP, yielding initiation-inactive ADP-DnaA.
Kazutoshi, Kasho +3 more
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Escherichia coli DnaA Protein Loads a Single DnaB Helicase at a DnaA Box Hairpin [PDF]
Journal of Biological Chemistry, 2002 The molecular engine that drives bidirectional replication fork movement from the Escherichia coli replication origin (oriC) is the replicative helicase, DnaB. At oriC, two and only two helicase molecules are loaded, one for each replication fork. DnaA participates in helicase loading; DnaC is also involved, because it must be in a complex with DnaB ...
Kevin M, Carr, Jon M, Kaguni
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Avoiding chromosome pathology when replication forks collide [PDF]
, 2013 This is the author's accepted manuscript. The final published article is available from the link below. Copyright @ 2013 Macmillan Publishers Limited.Chromosome duplication normally initiates through the assembly of replication fork complexes at defined ...
Lloyd, RG +3 more
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PLoS ONE, 2012 DnaA initiates chromosome replication in most known bacteria and its activity is controlled so that this event occurs only once every cell division cycle.
Tomer Regev +3 more
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The bacterial replication origin BUS promotes nucleobase capture
Nature Communications, 2023 Genome duplication is essential for the proliferation of cellular life and this process is generally initiated by dedicated replication proteins at chromosome origins.
Simone Pelliciari +14 more
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Frontiers in Microbiology, 2018 Although the mechanisms that precisely time initiation of chromosome replication in bacteria remain unclear, most clock models are based on accumulation of the active initiator protein, DnaA-ATP.
Prassanna Rao +4 more
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Frontiers in Microbiology, 2021 Genome duplication is a critical event in the reproduction cycle of every cell. Because all daughter cells must inherit a complete genome, chromosome replication is tightly regulated, with multiple mechanisms focused on controlling when chromosome ...
Julia E. Grimwade, Alan C. Leonard
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, 2019 DnaA is the widely conserved bacterial AAA+ ATPase that functions as both the replication initiator and a transcription factor. In many organisms, DnaA controls expression of its own gene and likely several others during growth and in response to ...
Grossman, Alan Davis +2 more
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