Results 21 to 30 of about 8,858 (210)
The DnaA Protein Is Not the Limiting Factor for Initiation of Replication in Escherichia coli. [PDF]
PLoS Genetics, 2015 The bacterial replication cycle is driven by the DnaA protein which cycles between the active ATP-bound form and the inactive ADP-bound form. It has been suggested that DnaA also is the main controller of initiation frequency.
Ingvild Flåtten +4 more
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Rapid turnover of DnaA at replication origin regions contributes to initiation control of DNA replication. [PDF]
PLoS Genetics, 2017 DnaA is a conserved key regulator of replication initiation in bacteria, and is homologous to ORC proteins in archaea and in eukaryotic cells. The ATPase binds to several high affinity binding sites at the origin region and upon an unknown molecular ...
Katrin Schenk +8 more
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, 2022 oriC is a region of the bacterial chromosome at which the initiator protein DnaA interacts with specific sequences, leading to DNA unwinding and the initiation of chromosome replication.
Weigel, Christoph +6 more
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Interaction of the Bacillus subtilis DnaA-like protein with the Escherichia coli DnaA protein [PDF]
Journal of Bacteriology, 1988 Plasmids carrying the intact Bacillus subtilis dnaA-like gene and two reciprocal hybrids between the B. subtilis and Escherichia coli dnaA genes were constructed. None of the plasmids could transform wild-type E. coli cells unless the cells contained surplus E. coli DnaA protein (DnaAEc).
L, Andrup +4 more
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eLife, 2021 The ability to regulate DNA replication initiation in response to changing nutrient conditions is an important feature of most cell types. In bacteria, DNA replication is triggered by the initiator protein DnaA, which has long been suggested to respond ...
Michele Felletti +3 more
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dnaA alleles are recessive [PDF]
Journal of Bacteriology, 1980 Dominance tests of several dnaA alleles from Escherichia coli, including two previously reported to be dominant, show that all of the mutant alleles examined are recessive to dnaA+.
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Frontiers in Microbiology, 2018 Chromosomal replication initiation requires dynamic mechanisms in higher-order nucleoprotein complexes that are constructed at the origin of replication.
Yukari Sakiyama +5 more
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Nutritional Control of DNA Replication Initiation through the Proteolysis and Regulated Translation of DnaA. [PDF]
PLoS Genetics, 2015 Bacteria can arrest their own growth and proliferation upon nutrient depletion and under various stressful conditions to ensure their survival. However, the molecular mechanisms responsible for suppressing growth and arresting the cell cycle under such ...
David J Leslie +7 more
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Changing Perspectives on the Role of DnaA-ATP in Orisome Function and Timing Regulation
Frontiers in Microbiology, 2019 Bacteria, like all cells, must precisely duplicate their genomes before they divide. Regulation of this critical process focuses on forming a pre-replicative nucleoprotein complex, termed the orisome.
Alan C. Leonard +3 more
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Occlusion of RNA Polymerase by Oligomerization of DnaA Protein over the dnaA Promoter of Escherichia coli [PDF]
Journal of Biological Chemistry, 1997 DnaA protein, the initiator protein for initiation of Escherichia coli chromosomal replication, has been shown to repress its own expression from two dnaA promoters, 1P and 2P. The sequence-specific binding of DnaA protein to the DnaA box, located between the two promoters, results in subsequent oligomerization of DnaA protein.
Y S, Lee, D S, Hwang
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