Blocking, Bending, and Binding: Regulation of Initiation of Chromosome Replication During the Escherichia coli Cell Cycle by Transcriptional Modulators That Interact With Origin DNA [PDF]
Frontiers in Microbiology, 2021 Genome duplication is a critical event in the reproduction cycle of every cell. Because all daughter cells must inherit a complete genome, chromosome replication is tightly regulated, with multiple mechanisms focused on controlling when chromosome ...
Julia E. Grimwade, Alan C. Leonard
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Antibiotics, 2019 All bacterial cells must duplicate their genomes prior to dividing into two identical daughter cells. Chromosome replication is triggered when a nucleoprotein complex, termed the orisome, assembles, unwinds the duplex DNA, and recruits the proteins ...
Julia E. Grimwade, Alan C. Leonard
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Defective replication initiation results in locus specific chromosome breakage and a ribosomal RNA deficiency in yeast. [PDF]
PLoS Genetics, 2017 A form of dwarfism known as Meier-Gorlin syndrome (MGS) is caused by recessive mutations in one of six different genes (ORC1, ORC4, ORC6, CDC6, CDT1, and MCM5).
Joseph C Sanchez +5 more
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DnaA binding to oriCII regulates transcription from Pseudomonas aeruginosa gidAB-parAB locus linked to the chromosome segregation and streptomycin resistance [PDF]
Scientific ReportsIn many bacteria, the DnaA protein, responsible for chromosome replication initiation, also acts as a transcription factor regulating its own gene expression and the expression of other loci.
Pawel Wawrzyniak +5 more
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Impact of Tau overexpression on DNA replication dynamics in centromeres of human neural progenitor cells [PDF]
iScienceSummary: Aging somatic cells are characterized by specific chromosome aneuploidy, particularly involving chromosome Y (ChrY) and chromosome 21 (Chr21), which are associated with Alzheimer’s disease (AD) pathology.
Elisa Balzano +13 more
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Origin recognition is the predominant role for DnaA-ATP in initiation of chromosome replication [PDF]
Nucleic Acids Research, 2018 Alan Leonard +2 more
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Frontiers in Molecular Biosciences, 2021 During steady-state Escherichia coli growth, the amount and activity of the initiator protein, DnaA, controls chromosome replication tightly so that initiation only takes place once per origin in each cell cycle, regardless of growth conditions. However,
Godefroid Charbon +6 more
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Evidence for two different regulatory mechanisms linking replication and segregation of vibrio cholerae chromosome II. [PDF]
PLoS Genetics, 2013 Understanding the mechanisms that coordinate replication initiation with subsequent segregation of chromosomes is an important biological problem. Here we report two replication-control mechanisms mediated by a chromosome segregation protein, ParB2 ...
Tatiana Venkova-Canova +4 more
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AdpA, key regulator for morphological differentiation regulates bacterial chromosome replication [PDF]
Open Biology, 2012 AdpA, one of the most pleiotropic transcription regulators in bacteria, controls expression of several dozen genes during Streptomyces differentiation.
Marcin Wolański +2 more
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Initiation of DNA replication from non-canonical sites on an origin-depleted chromosome. [PDF]
PLoS ONE, 2014 Eukaryotic DNA replication initiates from multiple sites on each chromosome called replication origins (origins). In the budding yeast Saccharomyces cerevisiae, origins are defined at discrete sites.
Naomi L Bogenschutz +2 more
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