Blocking, Bending, and Binding: Regulation of Initiation of Chromosome Replication During the Escherichia coli Cell Cycle by Transcriptional Modulators That Interact With Origin DNA [PDF]
Frontiers in Microbiology, 2021 Genome duplication is a critical event in the reproduction cycle of every cell. Because all daughter cells must inherit a complete genome, chromosome replication is tightly regulated, with multiple mechanisms focused on controlling when chromosome ...
Julia E. Grimwade, Alan C. Leonard
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Antibiotics, 2019 All bacterial cells must duplicate their genomes prior to dividing into two identical daughter cells. Chromosome replication is triggered when a nucleoprotein complex, termed the orisome, assembles, unwinds the duplex DNA, and recruits the proteins ...
Julia E. Grimwade, Alan C. Leonard
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oriC-encoded instructions for the initiation of bacterial chromosome replication
Frontiers in Microbiology, 2015 Replication of the bacterial chromosome initiates at a single origin of replication that is called oriC. This occurs via the concerted action of numerous proteins, including DnaA, which acts as an initiator.
Marcin eWolanski +3 more
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Extrusion-modulated DnaA activity oscillations coordinate DNA replication with biomass growth [PDF]
eLifeRobust control of DNA replication is fundamental to bacterial proliferation. In Escherichia coli, replication initiation is thought to be regulated by oscillations in DnaA activity, driven by DnaA-chromosome interactions that differ among leading models.
Dengjin Li +10 more
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Leishmania major chromosomes are replicated from a single high-efficiency locus supplemented by thousands of lower efficiency initiation events [PDF]
Cell ReportsSummary: DNA replication initiates at genome sites termed origins. Previous origin mapping approaches in the populations of the protozoan parasite Leishmania major were discordant, suggesting either a single origin per chromosome or 200-fold more origins.
Jeziel D. Damasceno +6 more
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Impact of Tau overexpression on DNA replication dynamics in centromeres of human neural progenitor cells [PDF]
iScienceSummary: Aging somatic cells are characterized by specific chromosome aneuploidy, particularly involving chromosome Y (ChrY) and chromosome 21 (Chr21), which are associated with Alzheimer’s disease (AD) pathology.
Elisa Balzano +13 more
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Origin recognition is the predominant role for DnaA-ATP in initiation of chromosome replication [PDF]
Nucleic Acids Research, 2018 Julia E Grimwade +2 more
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Frontiers in Molecular Biosciences, 2021 During steady-state Escherichia coli growth, the amount and activity of the initiator protein, DnaA, controls chromosome replication tightly so that initiation only takes place once per origin in each cell cycle, regardless of growth conditions. However,
Godefroid Charbon +6 more
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Evidence for two different regulatory mechanisms linking replication and segregation of vibrio cholerae chromosome II. [PDF]
PLoS Genetics, 2013 Understanding the mechanisms that coordinate replication initiation with subsequent segregation of chromosomes is an important biological problem. Here we report two replication-control mechanisms mediated by a chromosome segregation protein, ParB2 ...
Tatiana Venkova-Canova +4 more
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Defective replication initiation results in locus specific chromosome breakage and a ribosomal RNA deficiency in yeast. [PDF]
PLoS Genetics, 2017 A form of dwarfism known as Meier-Gorlin syndrome (MGS) is caused by recessive mutations in one of six different genes (ORC1, ORC4, ORC6, CDC6, CDT1, and MCM5).
Joseph C Sanchez +5 more
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