AdpA, key regulator for morphological differentiation regulates bacterial chromosome replication [PDF]
Open Biology, 2012 AdpA, one of the most pleiotropic transcription regulators in bacteria, controls expression of several dozen genes during Streptomyces differentiation.
Marcin Wolański +2 more
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Initiation of DNA replication from non-canonical sites on an origin-depleted chromosome. [PDF]
PLoS ONE, 2014 Eukaryotic DNA replication initiates from multiple sites on each chromosome called replication origins (origins). In the budding yeast Saccharomyces cerevisiae, origins are defined at discrete sites.
Naomi L Bogenschutz +2 more
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Life, 2023 The DnaA protein has long been considered to play the key role in the initiation of chromosome replication in modern bacteria. Many questions about this role, however, remain unanswered.
Masamichi Kohiyama +2 more
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Separation of DNA replication from the assembly of break-competent meiotic chromosomes. [PDF]
PLoS Genetics, 2012 The meiotic cell division reduces the chromosome number from diploid to haploid to form gametes for sexual reproduction. Although much progress has been made in understanding meiotic recombination and the two meiotic divisions, the processes leading up ...
Hannah G Blitzblau +3 more
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Re-replication of a centromere induces chromosomal instability and aneuploidy. [PDF]
PLoS Genetics, 2015 The faithful inheritance of chromosomes during cell division requires their precise replication and segregation. Numerous mechanisms ensure that each of these fundamental cell cycle events is performed with a high degree of fidelity.
Stacey L Hanlon, Joachim J Li
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High Osmolarity Modulates Bacterial Cell Size through Reducing Initiation Volume in
mSphere, 2018 Bacterial cell size is closely associated with biomass growth and cell cycle progression, including chromosome replication and cell division. It is generally proposed that Escherichia coli cells tightly control the timing of chromosome replication ...
Xiongfeng Dai, Manlu Zhu
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Transcription shapes DNA replication initiation to preserve genome integrity
Genome Biology, 2021 Background Early DNA replication occurs within actively transcribed chromatin compartments in mammalian cells, raising the immediate question of how early DNA replication coordinates with transcription to avoid collisions and DNA damage.
Yang Liu +10 more
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Structure and Function of the Campylobacter jejuni Chromosome Replication Origin
Frontiers in Microbiology, 2018 Campylobacter jejuni is the leading bacterial cause of foodborne infections worldwide. However, our understanding of its cell cycle is poor. We identified the probable C.
Pawel Jaworski +5 more
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Microbial Cell Factories, 2022 Background Generally, bacteria have a circular genome with a single replication origin for each replicon, whereas archaea and eukaryotes can have multiple replication origins in a single chromosome.
Hee Jin Yang +3 more
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Functional centromeres determine the activation time of pericentric origins of DNA replication in Saccharomyces cerevisiae. [PDF]
PLoS Genetics, 2012 The centromeric regions of all Saccharomyces cerevisiae chromosomes are found in early replicating domains, a property conserved among centromeres in fungi and some higher eukaryotes. Surprisingly, little is known about the biological significance or the
Thomas J Pohl +2 more
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