Both Chromosome Decondensation and Condensation Are Dependent on DNA Replication in C. elegans Embryos [PDF]
Cell Reports, 2015 During cell division, chromatin alternates between a condensed state to facilitate chromosome segregation and a decondensed form when DNA replicates.
Remi Sonneville +4 more
doaj +2 more sources
Ciz1 cooperates with cyclin-A-CDK2 to activate mammalian DNA replication in vitro [PDF]
, 2010 Initiation of mammalian DNA replication can be reconstituted from isolated G1-phase nuclei and cell extracts, supplemented with cyclin-dependent protein kinases (CDKs).
Sercombe, Heather E +3 more
core +4 more sources
Life, 2023 The DnaA protein has long been considered to play the key role in the initiation of chromosome replication in modern bacteria. Many questions about this role, however, remain unanswered.
Masamichi Kohiyama +2 more
doaj +1 more source
Separation of DNA replication from the assembly of break-competent meiotic chromosomes. [PDF]
PLoS Genetics, 2012 The meiotic cell division reduces the chromosome number from diploid to haploid to form gametes for sexual reproduction. Although much progress has been made in understanding meiotic recombination and the two meiotic divisions, the processes leading up ...
Hannah G Blitzblau +3 more
doaj +1 more source
Re-replication of a centromere induces chromosomal instability and aneuploidy. [PDF]
PLoS Genetics, 2015 The faithful inheritance of chromosomes during cell division requires their precise replication and segregation. Numerous mechanisms ensure that each of these fundamental cell cycle events is performed with a high degree of fidelity.
Stacey L Hanlon, Joachim J Li
doaj +1 more source
Mathematical modelling of whole chromosome replication [PDF]
, 2010 All chromosomes must be completely replicated prior to cell division, a requirement that demands the activation of a sufficient number of appropriately distributed DNA replication origins.
de Moura, Alessandro P.S. +4 more
core +1 more source
High Osmolarity Modulates Bacterial Cell Size through Reducing Initiation Volume in
mSphere, 2018 Bacterial cell size is closely associated with biomass growth and cell cycle progression, including chromosome replication and cell division. It is generally proposed that Escherichia coli cells tightly control the timing of chromosome replication ...
Xiongfeng Dai, Manlu Zhu
doaj +1 more source
Dynamic distribution of SeqA protein across the chromosome of Escherichia coli K-12 [PDF]
, 2010 The bacterial SeqA protein binds to hemi-methylated GATC sequences that arise in newly synthesized DNA upon passage of the replication machinery. In Escherichia coli K-12, the single replication origin oriC is a well-characterized target for SeqA, which ...
Stephen J. W. Busby +17 more
core +1 more source
Transcription shapes DNA replication initiation to preserve genome integrity
Genome Biology, 2021 Background Early DNA replication occurs within actively transcribed chromatin compartments in mammalian cells, raising the immediate question of how early DNA replication coordinates with transcription to avoid collisions and DNA damage.
Yang Liu +10 more
doaj +1 more source
Genome organization of DNA replication timing and its link to chromatin and transcription [PDF]
, 2008 The replication of the genome is a highly organized process. Not every sequence replicates at the same time, instead some genes replicate early, while others replicate later during S phase.
Schwaiger, Michaela
core +1 more source