Results 31 to 40 of about 167,569,374 (255)

Coupling between DNA replication, segregation, and the onset of constriction in Escherichia coli

Cell Reports, 2022
Summary: Escherichia coli cell cycle features two critical cell-cycle checkpoints: initiation of replication and the onset of constriction. While the initiation of DNA replication has been extensively studied, it is less clear what triggers the onset of ...
Sriram Tiruvadi-Krishnan, Jaana Männik, Prathitha Kar, Jie Lin, Ariel Amir, Jaan Männik   +5 more
doaj   +1 more source

oriC-encoded instructions for the initiation of bacterial chromosome replication

Frontiers in Microbiology, 2015
Replication of the bacterial chromosome initiates at a single origin of replication that is called oriC. This occurs via the concerted action of numerous proteins, including DnaA, which acts as an initiator.
Marcin eWolanski, Rafal eDonczew, Anna eZawilak-Pawlik, Jolanta eZakrzewska   +3 more
doaj   +1 more source

Cloning, expression, and chromosomal localization of the 140-kilodalton subunit of replication factor C from mice and humans [PDF]

, 1994
We have isolated a full-length mouse cDNA encoding a lysine-rich protein of 1,131 amino acids with a calculated molecular mass of 126 kDa. The protein binds in a sequence-unspecific manner to DNA, is localized exclusively in the nucleus, and contains a ...
Schütz, Günther, Stillman, B., Bunz, F., Lichter, P., Luckow, Bruno   +4 more
core   +2 more sources

The DNA replication initiation protein DnaD recognises a specific strand of the Bacillus subtilis chromosome origin [PDF]

, 2023
Genome replication is a fundamental biological activity shared by all organisms. Chromosomal replication proceeds bidirectionally from origins, requiring the loading of two helicases, one for each replisome. However, the molecular mechanisms underpinning
Tiago R D Costa, Nora B Cronin, Winterhalter, Charles, Marchand, E, Murray, H, Fenyk, S, Elie Marchand, Soultanas, P, Aravindan Ilangovan, Soultanas, Panos, Ilangovan, A, Daniel Stevens, Heath Murray, Panos Soultanas, Costa, TRD, Fenyk, Stepan, Costa, Tiago R.D., Cronin, Nora B, Winterhalter, C, Stevens, Daniel, Cronin, NB, Ilangovan, Aravindan, Costa, Tiago R D, Murray, Heath, Pelliciari, S, Stepan Fenyk, Simone Pelliciari, Charles Winterhalter, Pelliciari, Simone, Costa, Tiago RD, Stevens, D, Marchand, Elie   +31 more
core   +1 more source

Pathological replication in cells lacking RecG DNA translocase [PDF]

, 2009
This is an open access article, shared under a Creative Commons licence. Copyright © 2009 The Authors.Little is known about what happens when forks meet to complete DNA replication in any organism.
Lloyd, RG, Robert G. Lloyd, Lynda Harris, Harris, L, Christian J. Rudolph, Amy L. Upton, Rudolph, CJ, Upton, AL   +7 more
core   +1 more source

Leishmania major chromosomes are replicated from a single high-efficiency locus supplemented by thousands of lower efficiency initiation events

Cell Reports
Summary: DNA replication initiates at genome sites termed origins. Previous origin mapping approaches in the populations of the protozoan parasite Leishmania major were discordant, suggesting either a single origin per chromosome or 200-fold more origins.
Jeziel D. Damasceno, Gabriel L.A. Silva, Catarina A. Marques, Marija Krasilnikova, Craig Lapsley, Dario Beraldi, Richard McCulloch   +6 more
doaj   +1 more source

Ultrafine anaphase bridges, broken DNA and illegitimate recombination induced by a replication fork barrier [PDF]

, 2011
Most DNA double-strand breaks (DSBs) in S- and G2-phase cells are repaired accurately by Rad51-dependent sister chromatid recombination. However, a minority give rise to gross chromosome rearrangements (GCRs), which can result in disease/death.
Ledesma, Jennifer, Whitby, Matthew C., Castagnetti, S, Sofueva, Sevil, Alexander Lorenz, Steinacher, R, Fekret Osman, Lorenz, Alexander, Sofueva, S, Ledesma, J, Castagnetti, Stefania, Whitby, Matthew, Steinacher, Roland, Sevil Sofueva, Stefania Castagnetti, Osman, F, Lorenz, A, Matthew C. Whitby, Whitby, MC, Osman, Fekret, Roland Steinacher, Jennifer Ledesma   +21 more
core   +1 more source

Genome-wide analysis reveals extensive functional interaction between DNA replication initiation and transcription in the genome of trypanosoma brucei [PDF]

, 2012
Identification of replication initiation sites, termed origins, is a crucial step in understanding genome transmission in any organism. Transcription of the Trypanosoma brucei genome is highly unusual, with each chromosome comprising a few discrete ...
Dickens, N.J., Dickens, N, Kelly, S, Marcello, Lucio, Swiderski, M, Stephen D. Bell, Farr, Helen, Farr, H., Swiderski, M., Vaughan, D., Diane Vaughan, Bell, Stephen D, Nicholas Dickens, Marcello, L., Steven Kelly, Tiengwe, C, Dickens, Nicholas, Marcello, L, Bell, SD, Bell, Stephen D., Vaughan, D, McCulloch, R, Kelly, S., Swiderski, Michal, Keith Gull, Tiengwe, Calvin, Barry, J.D., McCulloch, R., Barry, J David, Barry, JD, Farr, H, Gull, K, Lucio Marcello, Richard McCulloch, J. David Barry, Bell, S.D., Calvin Tiengwe, McCulloch, Richard, Kelly, Steven, Helen Farr, Tiengwe, C., Gull, Keith, Barry, J. David, Vaughan, Diane, Gull, K., Michal Swiderski   +45 more
core   +1 more source

Targeting synthesis of the Chromosome Replication Initiator Protein DnaA by antisense PNA-peptide conjugates in Escherichia coli

Frontiers in Antibiotics
Initiation of chromosome replication is an essential stage of the bacterial cell cycle that is controlled by the DnaA protein. With the aim of developing novel antimicrobials, we have targeted the initiation of DNA replication, using antisense peptide ...
Christopher Campion, Christopher Campion, Godefroid Charbon, Peter E. Nielsen, Anders Løbner-Olesen   +4 more
doaj   +1 more source

Genome-wide hierarchy of replication origin usage in Saccharomyces cerevisiae. [PDF]

PLoS Genetics, 2006
Replication origins in a genome are inherently different in their base sequence and in their response to temporal and cell cycle regulation signals for DNA replication.
Justin J Donato, Shau Chee C Chung, Bik K Tye   +2 more
doaj   +1 more source