Results 21 to 30 of about 69,652 (212)

Coupling between DNA replication, segregation, and the onset of constriction in Escherichia coli

Cell Reports, 2022
Summary: Escherichia coli cell cycle features two critical cell-cycle checkpoints: initiation of replication and the onset of constriction. While the initiation of DNA replication has been extensively studied, it is less clear what triggers the onset of ...
Sriram Tiruvadi-Krishnan, Jaana Männik, Prathitha Kar, Jie Lin, Ariel Amir, Jaan Männik   +5 more
doaj   +1 more source

Where and When Bacterial Chromosome Replication Starts: A Single Cell Perspective

Frontiers in Microbiology, 2018
Bacterial chromosomes have a single, unique replication origin (named oriC), from which DNA synthesis starts. This study describes methods of visualizing oriC regions and the chromosome replication in single living bacterial cells in real-time.
Damian Trojanowski, Joanna Hołówka, Jolanta Zakrzewska-Czerwińska   +2 more
doaj   +1 more source

Genetic and physical mapping of DNA replication origins in Haloferax volcanii. [PDF]

PLoS Genetics, 2007
The halophilic archaeon Haloferax volcanii has a multireplicon genome, consisting of a main chromosome, three secondary chromosomes, and a plasmid. Genes for the initiator protein Cdc6/Orc1, which are commonly located adjacent to archaeal origins of DNA ...
Cédric Norais, Michelle Hawkins, Amber L Hartman, Jonathan A Eisen, Hannu Myllykallio, Thorsten Allers   +5 more
doaj   +1 more source

Targeting synthesis of the Chromosome Replication Initiator Protein DnaA by antisense PNA-peptide conjugates in Escherichia coli

Frontiers in Antibiotics
Initiation of chromosome replication is an essential stage of the bacterial cell cycle that is controlled by the DnaA protein. With the aim of developing novel antimicrobials, we have targeted the initiation of DNA replication, using antisense peptide ...
Christopher Campion, Christopher Campion, Godefroid Charbon, Peter E. Nielsen, Anders Løbner-Olesen   +4 more
doaj   +1 more source

Genome-wide hierarchy of replication origin usage in Saccharomyces cerevisiae. [PDF]

PLoS Genetics, 2006
Replication origins in a genome are inherently different in their base sequence and in their response to temporal and cell cycle regulation signals for DNA replication.
Justin J Donato, Shau Chee C Chung, Bik K Tye   +2 more
doaj   +1 more source

Two different cell-cycle processes determine the timing of cell division in Escherichia coli

eLife, 2021
Cells must control the cell cycle to ensure that key processes are brought to completion. In Escherichia coli, it is controversial whether cell division is tied to chromosome replication or to a replication-independent inter-division process.
Alexandra Colin, Gabriele Micali, Louis Faure, Marco Cosentino Lagomarsino, Sven van Teeffelen   +4 more
doaj   +1 more source

Real-time analysis of initiation regulation systems during the progression of the reconstituted chromosomal replication cycle

Scientific Reports
Chromosome replication in Escherichia coli is primarily regulated at the initiation stage, where the DnaA protein activates replication at the chromosomal origin, oriC.
Koki Kanoh, Masayuki Su’etsugu
doaj   +1 more source

Chromosome Dynamics in Bacteria: Triggering Replication at the Opposite Location and Segregation in the Opposite Direction

mBio, 2019
Maintaining the integrity of the genome is essential to cell survival. In the bacterium Caulobacter crescentus, the single circular chromosome exhibits a specific orientation in the cell, with the replication origin (ori) residing at the pole of the cell
Ady B. Meléndez, Inoka P. Menikpurage, Paola E. Mera   +2 more
doaj   +1 more source

Multiple regulatory mechanisms to inhibit untimely initiation of DNA replication are important for stable genome maintenance. [PDF]

PLoS Genetics, 2011
Genomic instability is a hallmark of human cancer cells. To prevent genomic instability, chromosomal DNA is faithfully duplicated in every cell division cycle, and eukaryotic cells have complex regulatory mechanisms to achieve this goal.
Seiji Tanaka, Hiroyuki Araki
doaj   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source