The Emerging Roles of Fox Family Transcription Factors in Chromosome Replication, Organization, and Genome Stability [PDF]
Cells, 2020 The forkhead box (Fox) transcription factors (TFs) are widespread from yeast to humans. Their mutations and dysregulation have been linked to a broad spectrum of malignant neoplasias.
Yue Jin, Zhangqian Liang, Huiqiang Lou
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Where and When Bacterial Chromosome Replication Starts: A Single Cell Perspective [PDF]
Frontiers in Microbiology, 2018 Bacterial chromosomes have a single, unique replication origin (named oriC), from which DNA synthesis starts. This study describes methods of visualizing oriC regions and the chromosome replication in single living bacterial cells in real-time.
Damian Trojanowski +2 more
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Efficient Arrangement of the Replication Fork Trap for In Vitro Propagation of Monomeric Circular DNA in the Chromosome-Replication Cycle Reaction [PDF]
Life, 2018 Propagation of genetic information is a fundamental prerequisite for living cells. We recently developed the replication cycle reaction (RCR), an in vitro reaction for circular DNA propagation, by reconstitution of the replication cycle of the ...
Tomonori Hasebe +3 more
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ASAR15, A cis-acting locus that controls chromosome-wide replication timing and stability of human chromosome 15. [PDF]
PLoS Genetics, 2015 DNA replication initiates at multiple sites along each mammalian chromosome at different times during each S phase, following a temporal replication program.
Nathan Donley +2 more
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Crosstalk Regulation Between Bacterial Chromosome Replication and Chromosome Partitioning [PDF]
Frontiers in Microbiology, 2019 Despite much effort, the bacterial cell cycle has proved difficult to study and understand. Bacteria do not conform to the standard eukaryotic model of sequential cell-cycle phases.
Gregory T. Marczynski +2 more
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Structure and Function of the Campylobacter jejuni Chromosome Replication Origin [PDF]
Frontiers in Microbiology, 2018 Campylobacter jejuni is the leading bacterial cause of foodborne infections worldwide. However, our understanding of its cell cycle is poor. We identified the probable C.
Pawel Jaworski +5 more
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Targeting synthesis of the Chromosome Replication Initiator Protein DnaA by antisense PNA-peptide conjugates in Escherichia coli [PDF]
Frontiers in AntibioticsInitiation of chromosome replication is an essential stage of the bacterial cell cycle that is controlled by the DnaA protein. With the aim of developing novel antimicrobials, we have targeted the initiation of DNA replication, using antisense peptide ...
Christopher Campion +4 more
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Functionality of Two Origins of Replication in Vibrio cholerae Strains With a Single Chromosome
Frontiers in Microbiology, 2018 Chromosomal inheritance in bacteria usually entails bidirectional replication of a single chromosome from a single origin into two copies and subsequent partitioning of one copy each into daughter cells upon cell division.
Matthias Bruhn +9 more
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Rad53 checkpoint kinase regulation of DNA replication fork rate via Mrc1 phosphorylation
eLife, 2021 The Rad53 DNA checkpoint protein kinase plays multiple roles in the budding yeast cell response to DNA replication stress. Key amongst these is its enigmatic role in safeguarding DNA replication forks.
Allison W McClure, John FX Diffley
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The chromosome replication cycle [PDF]
Journal of Cell Science, 2002 To ensure that the relatively large genomes of eukaryotic cells are efficiently and precisely duplicated in each cell cycle, DNA replication initiates from multiple replication origins distributed along the individual chromosomes.
John F X, Diffley, Karim, Labib
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