Results 1 to 10 of about 693,747 (160)
ASAR15, A cis-Acting Locus that Controls Chromosome-Wide Replication Timing and Stability of Human Chromosome 15 [PDF]
PLoS Genetics, 2015 DNA replication initiates at multiple sites along each mammalian chromosome at different times during each S phase, following a temporal replication program.
Leslie Smith +2 more
exaly +2 more sources
Life, 2018 Propagation of genetic information is a fundamental prerequisite for living cells. We recently developed the replication cycle reaction (RCR), an in vitro reaction for circular DNA propagation, by reconstitution of the replication cycle of the ...
Masayuki Su'estugu
exaly +3 more sources
Cells, 2020 The forkhead box (Fox) transcription factors (TFs) are widespread from yeast to humans. Their mutations and dysregulation have been linked to a broad spectrum of malignant neoplasias.
Huiqiang Lou
exaly +3 more sources
Rad53 checkpoint kinase regulation of DNA replication fork rate via Mrc1 phosphorylation
eLife, 2021 The Rad53 DNA checkpoint protein kinase plays multiple roles in the budding yeast cell response to DNA replication stress. Key amongst these is its enigmatic role in safeguarding DNA replication forks.
Allison W McClure, John FX Diffley
doaj +1 more source
Evolutionary Trajectory of the Replication Mode of Bacterial Replicons
mBio, 2021 Chromosome replication is an essential process for cell division. The mode of chromosome replication has important impacts on the structure of the chromosome and replication speed.
Bin-Bin Xie +14 more
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The chromosome replication cycle [PDF]
Journal of Cell Science, 2002 To ensure that the relatively large genomes of eukaryotic cells are efficiently and precisely duplicated in each cell cycle, DNA replication initiates from multiple replication origins distributed along the individual chromosomes.
John F X, Diffley, Karim, Labib
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Multiplex Cell Fate Tracking by Flow Cytometry
Methods and Protocols, 2020 Measuring differences in cell cycle progression is often essential to understand cell behavior under different conditions, treatments and environmental changes. Cell synchronization is widely used for this purpose, but unfortunately, there are many cases
Marta Rodríguez-Martínez +3 more
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Initiation of DNA replication from non-canonical sites on an origin-depleted chromosome. [PDF]
PLoS ONE, 2014 Eukaryotic DNA replication initiates from multiple sites on each chromosome called replication origins (origins). In the budding yeast Saccharomyces cerevisiae, origins are defined at discrete sites.
Naomi L Bogenschutz +2 more
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The replication fork trap and termination of chromosome replication [PDF]
Molecular Microbiology, 2008 SummaryBacteria that have a circular chromosome with a bidirectional DNA replication origin are thought to utilize a ‘replication fork trap’ to control termination of replication. The fork trap is an arrangement of replication pause sites that ensures that the two replication forks fuse within the terminus region of the chromosome, approximately ...
Duggin, I, Wake, R, Bell, S, Hill, T
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Defective replication initiation results in locus specific chromosome breakage and a ribosomal RNA deficiency in yeast. [PDF]
PLoS Genetics, 2017 A form of dwarfism known as Meier-Gorlin syndrome (MGS) is caused by recessive mutations in one of six different genes (ORC1, ORC4, ORC6, CDC6, CDT1, and MCM5).
Joseph C Sanchez +5 more
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