Asynchronous replication, mono-allelic expression, and long range Cis-effects of ASAR6. [PDF]
PLoS Genetics, 2013 Mammalian chromosomes initiate DNA replication at multiple sites along their length during each S phase following a temporal replication program. The majority of genes on homologous chromosomes replicate synchronously. However, mono-allelically expressed
Nathan Donley +4 more
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Genome organization of DNA replication timing and its link to chromatin and transcription [PDF]
, 2008 The replication of the genome is a highly organized process. Not every sequence replicates at the same time, instead some genes replicate early, while others replicate later during S phase.
Schwaiger, Michaela
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Prokaryotic ParA–ParB–parS system links bacterial chromosome segregation with the cell cycle [PDF]
, 2012 While the essential role of episomal par loci in plasmid DNA partitioning has long been appreciated, the function of chromosomally encoded par loci is less clear. The chromosomal parA–parB genes are conserved throughout the bacterial kingdom and encode
Mierzejewska, Jolanta +3 more
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Cryo-EM structure of a licensed DNA replication origin
Nature Communications, 2017 Origins of replication are licensed by loading of MCM onto DNA, and origin firing depends on interaction with Cdc45 and GINS to form two CMG holo-helicases. Here, authors determine the cryo-EM structures of DNA-bound MCM and visualise a phospho-dependent
Ferdos Abid Ali +6 more
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Chromosome replication in Myxococcus xanthus [PDF]
Journal of Bacteriology, 1978 The rates of DNA synthesis during the cell-division cycle were measured in Myxococcus xanthus growing in three different media permitting a twofold variation in doubling time. In all three media, simple DNA cycles were observed. Synthesis of DNA occurred during 85% of the cell-division cycle, independent of generation time, from 5 to 11 h.
D R, Zusman, D M, Krotoski, M, Cumsky
openaire +2 more sources
The DNA helicase Pfh1 promotes fork merging at replication termination sites to ensure genome stability [PDF]
, 2012 Bidirectionally moving DNA replication forks merge at termination sites composed of accidental or programmed DNA-protein barriers. If merging fails, then regions of unreplicated DNA can result in the breakage of DNA during mitosis, which in turn can give
Steinacher, R. +14 more
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Segregation but Not Replication of the
mBio, 2018 Coordination between chromosome replication and segregation is essential for equal partitioning of genetic material between daughter cells. In bacteria, this is achieved through the proximity of the origin of replication, oriC, and the chromosome ...
Bijit K. Bhowmik +3 more
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Estimation of the Minimum Number of Replication Origins Per Chromosome in any Organism
Bio-Protocol, 2020 Eukaryote nuclear genomes predominantly replicate through multiple replication origins. The number of replication origins activated per chromosome during the S-phase duration may vary according to many factors, but the predominant one is replication ...
Marcelo da Silva
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Evidence for two different regulatory mechanisms linking replication and segregation of vibrio cholerae chromosome II. [PDF]
PLoS Genetics, 2013 Understanding the mechanisms that coordinate replication initiation with subsequent segregation of chromosomes is an important biological problem. Here we report two replication-control mechanisms mediated by a chromosome segregation protein, ParB2 ...
Tatiana Venkova-Canova +4 more
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Replication factory activation can be decoupled from the replication timing program by modulating Cdk levels [PDF]
, 2010 In the metazoan replication timing program, clusters of replication origins located in different subchromosomal domains fire at different times during S phase. We have used Xenopus laevis egg extracts to drive an accelerated replication timing program in
Blow, J. Julian; id_orcid +6 more
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