Results 31 to 40 of about 693,747 (160)
The DNA helicase Pfh1 promotes fork merging at replication termination sites to ensure genome stability [PDF]
, 2012 Bidirectionally moving DNA replication forks merge at termination sites composed of accidental or programmed DNA-protein barriers. If merging fails, then regions of unreplicated DNA can result in the breakage of DNA during mitosis, which in turn can give
Steinacher, R. +14 more
core +1 more source
Segregation but Not Replication of the
mBio, 2018 Coordination between chromosome replication and segregation is essential for equal partitioning of genetic material between daughter cells. In bacteria, this is achieved through the proximity of the origin of replication, oriC, and the chromosome ...
Bijit K. Bhowmik +3 more
doaj +1 more source
H3 K36 Methylation Helps Determine the Timing of Cdc45 Association with Replication Origins [PDF]
, 2009 BackgroundReplication origins fire at different times during S-phase. Such timing is determined by the chromosomal context, which includes the activity of nearby genes, telomeric position effects and chromatin structure, such as the acetylation state of ...
Mariotti, F.R. +11 more
core +2 more sources
Estimation of the Minimum Number of Replication Origins Per Chromosome in any Organism
Bio-Protocol, 2020 Eukaryote nuclear genomes predominantly replicate through multiple replication origins. The number of replication origins activated per chromosome during the S-phase duration may vary according to many factors, but the predominant one is replication ...
Marcelo da Silva
doaj +1 more source
Evidence for two different regulatory mechanisms linking replication and segregation of vibrio cholerae chromosome II. [PDF]
PLoS Genetics, 2013 Understanding the mechanisms that coordinate replication initiation with subsequent segregation of chromosomes is an important biological problem. Here we report two replication-control mechanisms mediated by a chromosome segregation protein, ParB2 ...
Tatiana Venkova-Canova +4 more
doaj +1 more source
The MatP/matS Site-Specific System Organizes the Terminus Region of the E. coli Chromosome into a Macrodomain [PDF]
, 2008 The organization of the Escherichia coli chromosome into insulated macrodomains influences the segregation of sister chromatids and the mobility of chromosomal DNA.
El Karoui, Meriem +7 more
core +1 more source
Nature Communications, 2016 In fast proliferating embryonic stem cells (ESC) the DNA damage response is activated by mechanisms that are as yet elusive. Here, Ahuja et al.link the DNA damage response to replication stress in mouse ESCs, caused by a short G1 phase, and propose fork ...
Akshay K. Ahuja +10 more
doaj +1 more source
mBio, 2012 Vibrio cholerae has two chromosomes (chrI and chrII) whose replication and segregation are under different genetic controls. The region covering the replication origin of chrI resembles that of the Escherichia coli chromosome, and both origins are under ...
Ryosuke Kadoya, Dhruba K. Chattoraj
doaj +1 more source
Replication factory activation can be decoupled from the replication timing program by modulating Cdk levels [PDF]
, 2010 In the metazoan replication timing program, clusters of replication origins located in different subchromosomal domains fire at different times during S phase. We have used Xenopus laevis egg extracts to drive an accelerated replication timing program in
Blow, J. Julian; id_orcid +6 more
core +1 more source
Nature Communications, 2023 Chromatin replication involves the assembly and activity of the replisome within the nucleosomal landscape. At the core of the replisome is the Mcm2-7 complex (MCM), which is loaded onto DNA after binding to the Origin Recognition Complex (ORC). In yeast,
Humberto Sánchez +5 more
doaj +1 more source