Results 41 to 50 of about 234,024 (306)
Nature Communications, 2016 In fast proliferating embryonic stem cells (ESC) the DNA damage response is activated by mechanisms that are as yet elusive. Here, Ahuja et al.link the DNA damage response to replication stress in mouse ESCs, caused by a short G1 phase, and propose fork ...
Akshay K. Ahuja +10 more
doaj +1 more source
mBio, 2012 Vibrio cholerae has two chromosomes (chrI and chrII) whose replication and segregation are under different genetic controls. The region covering the replication origin of chrI resembles that of the Escherichia coli chromosome, and both origins are under ...
Ryosuke Kadoya, Dhruba K. Chattoraj
doaj +1 more source
The MatP/matS Site-Specific System Organizes the Terminus Region of the E. coli Chromosome into a Macrodomain [PDF]
, 2008 The organization of the Escherichia coli chromosome into insulated macrodomains influences the segregation of sister chromatids and the mobility of chromosomal DNA.
El Karoui, Meriem +7 more
core +1 more source
Nature Communications, 2023 Chromatin replication involves the assembly and activity of the replisome within the nucleosomal landscape. At the core of the replisome is the Mcm2-7 complex (MCM), which is loaded onto DNA after binding to the Origin Recognition Complex (ORC). In yeast,
Humberto Sánchez +5 more
doaj +1 more source
Cloning, expression, and chromosomal localization of the 140-kilodalton subunit of replication factor C from mice and humans [PDF]
, 1994 We have isolated a full-length mouse cDNA encoding a lysine-rich protein of 1,131 amino acids with a calculated molecular mass of 126 kDa. The protein binds in a sequence-unspecific manner to DNA, is localized exclusively in the nucleus, and contains a ...
Schütz, Günther +6 more
core +1 more source
Avoiding chromosome pathology when replication forks collide [PDF]
, 2013 This is the author's accepted manuscript. The final published article is available from the link below. Copyright @ 2013 Macmillan Publishers Limited.Chromosome duplication normally initiates through the assembly of replication fork complexes at defined ...
Lloyd, RG +3 more
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Separation of DNA replication from the assembly of break-competent meiotic chromosomes. [PDF]
PLoS Genetics, 2012 The meiotic cell division reduces the chromosome number from diploid to haploid to form gametes for sexual reproduction. Although much progress has been made in understanding meiotic recombination and the two meiotic divisions, the processes leading up ...
Hannah G Blitzblau +3 more
doaj +1 more source
Differential Requirements for MCM Proteins in DNA Replication in Drosophila S2 Cells. [PDF]
, 2007 BACKGROUND: The MCM2-7 proteins are crucial components of the pre replication complex (preRC) in eukaryotes. Since they are significantly more abundant than other preRC components, we were interested in determining whether the entire cellular content was
Reina Hashimoto +30 more
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Chromosome-wide profiles of replication timing and repair.
, 2022 Replication timing profiles are shown for chromosome 1 and 19 until 50 Mb. Profiles are colored by the local ratio of (A) normalized repair rate and (B) Early/Late S phase normalized repair rate of CPD 12 minutes samples. (TIF)
Jinchuan Hu (1909264) +7 more
core +1 more source
Chromosome Organization and Replisome Dynamics in
mBio, 2015 Subcellular organization of the bacterial nucleoid and spatiotemporal dynamics of DNA replication and segregation have been studied intensively, but the functional link between these processes remains poorly understood.
Isabella Santi, John D. McKinney
doaj +1 more source