Results 21 to 30 of about 234,024 (306)

Cdc7-Dbf4 Kinase Overexpression in Multiple Cancers and Tumor Cell Lines Is Correlated with p53 Inactivation

Neoplasia: An International Journal for Oncology Research, 2008
Cdc7 is a conserved serine/threonine kinase essential for the initiation of DNA replication, likely by activating the MCM DNA helicase at the G1- to S-phase transition.
Dorine Bonte, Charlotta Lindvall, Hongyu Liu, Karl Dykema, Kyle Furge, Michael Weinreich   +5 more
doaj   +1 more source

Replication fork collisions cause pathological chromosomal amplification in cells lacking RecG DNA translocase [PDF]

, 2009
This is an open access article, shared under a Creative Commons licence. Copyright © 2009 The Authors.Duplication and transmission of chromosomes require precise control of chromosome replication and segregation.
Lloyd, RG, Robert G. Lloyd, Christian J. Rudolph, Amy L. Upton, Upton, AL   +4 more
core   +1 more source

Chromosome structuring limits genome plasticity in Escherichia coli. [PDF]

PLoS Genetics, 2007
Chromosome organizations of related bacterial genera are well conserved despite a very long divergence period. We have assessed the forces limiting bacterial genome plasticity in Escherichia coli by measuring the respective effect of altering different ...
Emilie Esnault, Michèle Valens, Olivier Espéli, Frédéric Boccard   +3 more
doaj   +1 more source

Pathological replication in cells lacking RecG DNA translocase [PDF]

, 2009
This is an open access article, shared under a Creative Commons licence. Copyright © 2009 The Authors.Little is known about what happens when forks meet to complete DNA replication in any organism.
Lloyd, RG, Robert G. Lloyd, Lynda Harris, Harris, L, Christian J. Rudolph, Amy L. Upton, Rudolph, CJ, Upton, AL   +7 more
core   +1 more source

Cdt1 stabilizes an open MCM ring for helicase loading

Nature Communications, 2017
The loading and activation of the Mcm2-7 replicative helicase couples cell cycle progression to DNA replication. Here the authors use X-ray crystallography and single-particle electron microscopy to demonstrate how Ctd1 functions to promote MCM loading ...
Jordi Frigola, Jun He, Kerstin Kinkelin, Valerie E. Pye, Ludovic Renault, Max E. Douglas, Dirk Remus, Peter Cherepanov, Alessandro Costa, John F. X. Diffley   +9 more
doaj   +1 more source

Genome duplication in Leishmania major relies on persistent subtelomeric DNA replication

eLife, 2020
DNA replication is needed to duplicate a cell’s genome in S phase and segregate it during cell division. Previous work in Leishmania detected DNA replication initiation at just a single region in each chromosome, an organisation predicted to be ...
Jeziel Dener Damasceno, Catarina A Marques, Dario Beraldi, Kathryn Crouch, Craig Lapsley, Ricardo Obonaga, Luiz RO Tosi, Richard McCulloch   +7 more
doaj   +1 more source

Chromosomal macrodomains and associated proteins : implications for DNA organization and replication in gram negative bacteria [PDF]

, 2011
The Escherichia coli chromosome is organized into four macrodomains, the function and organisation of which are poorly understood. In this review we focus on the MatP, SeqA, and SlmA proteins that have recently been identified as the first examples of ...
Kalmykowa, Olga J., Remus T. Dame, Kalmykowa, OJ, Dame Remus T., Grainger David C., Dame, Remus T. (Remus Thei), David C Grainger, Grainger, David, Kalmykowa Olga J., David C. Grainger, Dame, RT, Olga J Kalmykowa, Grainger, David C., Remus T Dame, Olga J. Kalmykowa   +14 more
core   +1 more source

Units of chromosome replication and packing [PDF]

Journal of Cell Science, 1983
ABSTRACT Fusion between mitotic and S-phase cells induces the formation of prematurely condensed chromosomes (PCC) in the interphase partner. Viewed in the light microscope, S-phase PCC derived from the Indian muntjac appear to be fragmented and heterogeneous. In scanning electron micrographs prepared by an osmium impregnation technique,
A M, Mullinger, R T, Johnson
openaire   +2 more sources

Ultrafine anaphase bridges, broken DNA and illegitimate recombination induced by a replication fork barrier [PDF]

, 2011
Most DNA double-strand breaks (DSBs) in S- and G2-phase cells are repaired accurately by Rad51-dependent sister chromatid recombination. However, a minority give rise to gross chromosome rearrangements (GCRs), which can result in disease/death.
Ledesma, Jennifer, Whitby, Matthew C., Castagnetti, S, Sofueva, Sevil, Alexander Lorenz, Steinacher, R, Fekret Osman, Lorenz, Alexander, Sofueva, S, Ledesma, J, Castagnetti, Stefania, Whitby, Matthew, Steinacher, Roland, Sevil Sofueva, Stefania Castagnetti, Osman, F, Lorenz, A, Matthew C. Whitby, Whitby, MC, Osman, Fekret, Roland Steinacher, Jennifer Ledesma   +21 more
core   +1 more source

Structure of DNA-CMG-Pol epsilon elucidates the roles of the non-catalytic polymerase modules in the eukaryotic replisome

Nature Communications, 2018
Eukaryotic origin firing depends on assembly of the Cdc45-MCM-GINS (CMG) helicase, which requires the leading-strand polymerase Pol ɛ. Here the authors present a structural analysis of a CMG Pol ɛ on a DNA fork, providing insight on the steps leading ...
Panchali Goswami, Ferdos Abid Ali, Max E. Douglas, Julia Locke, Andrew Purkiss, Agnieszka Janska, Patrik Eickhoff, Anne Early, Andrea Nans, Alan M. C. Cheung, John F. X. Diffley, Alessandro Costa   +11 more
doaj   +1 more source