Dynamic Distribution of SeqA Protein across the Chromosome of
mBio, 2010 The bacterial SeqA protein binds to hemi-methylated GATC sequences that arise in newly synthesized DNA upon passage of the replication machinery. In Escherichia coli K-12, the single replication origin oriC is a well-characterized target for SeqA, which ...
María Antonia Sánchez-Romero +5 more
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Evolutionary Trajectory of the Replication Mode of Bacterial Replicons
mBio, 2021 Chromosome replication is an essential process for cell division. The mode of chromosome replication has important impacts on the structure of the chromosome and replication speed.
Bin-Bin Xie +14 more
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Multiplex Cell Fate Tracking by Flow Cytometry
Methods and Protocols, 2020 Measuring differences in cell cycle progression is often essential to understand cell behavior under different conditions, treatments and environmental changes. Cell synchronization is widely used for this purpose, but unfortunately, there are many cases
Marta Rodríguez-Martínez +3 more
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Initiation of DNA replication from non-canonical sites on an origin-depleted chromosome. [PDF]
PLoS ONE, 2014 Eukaryotic DNA replication initiates from multiple sites on each chromosome called replication origins (origins). In the budding yeast Saccharomyces cerevisiae, origins are defined at discrete sites.
Naomi L Bogenschutz +2 more
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The replication fork trap and termination of chromosome replication [PDF]
Molecular Microbiology, 2008 SummaryBacteria that have a circular chromosome with a bidirectional DNA replication origin are thought to utilize a ‘replication fork trap’ to control termination of replication. The fork trap is an arrangement of replication pause sites that ensures that the two replication forks fuse within the terminus region of the chromosome, approximately ...
Duggin, I, Wake, R, Bell, S, Hill, T
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Defective replication initiation results in locus specific chromosome breakage and a ribosomal RNA deficiency in yeast. [PDF]
PLoS Genetics, 2017 A form of dwarfism known as Meier-Gorlin syndrome (MGS) is caused by recessive mutations in one of six different genes (ORC1, ORC4, ORC6, CDC6, CDT1, and MCM5).
Joseph C Sanchez +5 more
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Dynamics of DNA replication during premeiosis and early meiosis in wheat. [PDF]
PLoS ONE, 2014 Meiosis is a specialised cell division that involves chromosome replication, two rounds of chromosome segregation and results in the formation of the gametes.
María-Dolores Rey, Pilar Prieto
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Mathematical modelling of whole chromosome replication [PDF]
, 2010 All chromosomes must be completely replicated prior to cell division, a requirement that demands the activation of a sufficient number of appropriately distributed DNA replication origins.
de Moura, Alessandro P.S. +4 more
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Genome Biology, 2022 Background A major driver of cancer chromosomal instability is replication stress, the slowing or stalling of DNA replication. How replication stress and genomic instability are connected is not known.
Nadeem Shaikh +11 more
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Both Chromosome Decondensation and Condensation Are Dependent on DNA Replication in C.elegans Embryos [PDF]
, 2015 During cell division, chromatin alternates between a condensed state to facilitate chromosome segregation and a decondensed form when DNA replicates.
Blow, J. Julian; id_orcid +11 more
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