oriC-encoded instructions for the initiation of bacterial chromosome replication [PDF]
Frontiers in Microbiology, 2015 Replication of the bacterial chromosome initiates at a single origin of replication that is called oriC. This occurs via the concerted action of numerous proteins, including DnaA, which acts as an initiator.
Rafal Donczew +2 more
exaly +6 more sources
The DnaA AAA+ Domain His136 Residue Directs DnaB Replicative Helicase to the Unwound Region of the Replication Origin, oriC [PDF]
Frontiers in Microbiology, 2018 Chromosomal replication initiation requires dynamic mechanisms in higher-order nucleoprotein complexes that are constructed at the origin of replication.
Shogo Ozaki +2 more
exaly +4 more sources
COMPUTER CONTROL SYSTEM FOR ORIC. [PDF]
AIP Conference Proceedings, 1972 A computer control system is being implemented for the Oak Ridge Isochronous Cyclotron (ORIC). At the start of a run, operating parameters are set automatically using data stored in a disc library. Adjustments of these parameters are made through an operator-computer interface consisting of a CRT unit with a keyboard. An array of assignable push-button
Ludemann, C.A. +2 more
core +4 more sources
SMC ensures efficient chromosome replication and oriC positioning during Streptomyces spore germination [PDF]
Scientific ReportsBacterial chromosomes are organized by condensins, such as Structural Maintenance of Chromosomes (SMC) proteins. In Streptomyces, a genus of sporulating bacteria, SMC proteins align chromosomal arms and promote efficient compaction of chromosomal DNA ...
Katarzyna Pawlikiewicz +7 more
doaj +2 more sources
Primosomal protein PriC rescues replication initiation stress by bypassing the DnaA-DnaB interaction step for DnaB helicase loading at oriC [PDF]
eLifeIn Escherichia coli, replisome and replication fork assembly is initiated by DnaB helicase loading at the chromosomal origin oriC via its interactions with the DnaA initiator and the DnaC helicase loader.
Ryusei Yoshida +4 more
doaj +2 more sources
Organizational readiness for implementing clinical decision support tools in chronic pain care: a mixed methods evaluation [PDF]
Frontiers in Health ServicesIntroductionClinical decision support (CDS) tools have the potential to enhance treatment outcomes in chronic pain care, yet their successful implementation depends on the readiness of both providers and clinical staff.
Miranda J. Reid +9 more
doaj +2 more sources
An additional replication origin causes cell cycle specific DNA replication fork speed [PDF]
Frontiers in MicrobiologyReplication fork speed (RFS) in Escherichia coli has long been considered constant throughout the replication and cell cycles. In wild-type cells, the circular chromosome is duplicated bidirectionally from oriC, yielding two replication forks that ...
Ole Skovgaard
doaj +2 more sources
Real-time analysis of initiation regulation systems during the progression of the reconstituted chromosomal replication cycle [PDF]
Scientific ReportsChromosome replication in Escherichia coli is primarily regulated at the initiation stage, where the DnaA protein activates replication at the chromosomal origin, oriC.
Koki Kanoh, Masayuki Su’etsugu
doaj +2 more sources
Measuring Organizational Readiness for Implementing Change in Primary Care Facilities in Rural Bushbuckridge, South Africa [PDF]
International Journal of Health Policy and Management, 2022 Meaningful gains in health outcomes require successful implementation of evidence-based interventions. Organizations such as health facilities must be ready to implement efficacious interventions, but tools to measure organizational readiness have rarely
Hannah H. Leslie +6 more
doaj +1 more source
Frontiers in Microbiology, 2021 The structure and function of bacterial chromosomes are dynamically regulated by a wide variety of nucleoid-associated proteins (NAPs) and DNA superstructures, such as DNA supercoiling.
Kazutoshi Kasho +5 more
doaj +1 more source