Results 1 to 10 of about 247,057 (165)
The Role of MTBP as a Replication Origin Firing Factor [PDF]
Biology, 2022 The initiation step of replication at replication origins determines when and where in the genome replication machines, replisomes, are generated. Tight control of replication initiation helps facilitate the two main tasks of genome replication, to ...
Eman Zaffar +3 more
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Neural network and kinetic modelling of human genome replication reveal replication origin locations and strengths. [PDF]
PLoS Computational Biology, 2023 In human and other metazoans, the determinants of replication origin location and strength are still elusive. Origins are licensed in G1 phase and fired in S phase of the cell cycle, respectively.
Jean-Michel Arbona +5 more
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An Orc1 initiator-specific motif (ISM)-related region limits ORC–ssDNA binding and promotes replication origin specificity in budding yeast [PDF]
Frontiers in MicrobiologySingle-stranded DNA (ssDNA) is an essential intermediate of genome duplication but can also arise in the genome, including at highly transcribed loci. Although the origin recognition complex (ORC), a eukaryotic replication initiator, has been reported to
Hironori Kawakami +8 more
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Dynamics of replication origin over-activation [PDF]
Nature Communications, 2021 DNA replication processes are often dysregulated in cancer. Here the authors analyse DNA synthesis patterns in cancer cells undergoing partial genome re-replication to reveal that re-replication exhibits aberrant replication fork dynamics and a skewed ...
Haiqing Fu +15 more
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Cold Spring Harbor Perspectives in Biology, 2013 The onset of genomic DNA synthesis requires precise interactions of specialized initiator proteins with DNA at sites where the replication machinery can be loaded. These sites, defined as replication origins, are found at a few unique locations in all of the prokaryotic chromosomes examined so far.
A. C. Leonard, M. Mechali
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Cell Reports, 2020 Summary: The processes that control where higher eukaryotic cells initiate DNA replication throughout the genome are not understood clearly. In metazoans, the Treslin-MTBP complex mediates critical final steps in formation of the activated replicative ...
Akiko Kumagai, William G. Dunphy
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Frontiers in Microbiology, 2021 Genome duplication is a critical event in the reproduction cycle of every cell. Because all daughter cells must inherit a complete genome, chromosome replication is tightly regulated, with multiple mechanisms focused on controlling when chromosome ...
Julia E. Grimwade, Alan C. Leonard
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An explanation for origin unwinding in eukaryotes
eLife, 2019 Twin CMG complexes are assembled head-to-head around duplex DNA at eukaryotic origins of replication. Mcm10 activates CMGs to form helicases that encircle single-strand (ss) DNA and initiate bidirectional forks.
Lance D Langston, Michael E O'Donnell
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PLOS Genetics, 2019 In all kingdoms of life, DNA is used to encode hereditary information. Propagation of the genetic material between generations requires timely and accurate duplication of DNA by semiconservative replication prior to cell division to ensure each daughter cell receives the full complement of chromosomes.
Babatunde Ekundayo, Franziska Bleichert
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Regulation of Replication Origins [PDF]
, 2017 In eukaryotes, genome duplication starts concomitantly at many replication initiation sites termed replication origins. The replication initiation program is spatially and temporally coordinated to ensure accurate, efficient DNA synthesis that duplicates the entire genome while maintaining other chromatin-dependent functions. Unlike in prokaryotes, not
Anna B, Marks +2 more
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