Results 1 to 10 of about 235,494 (215)

The Role of MTBP as a Replication Origin Firing Factor [PDF]

Biology, 2022
The initiation step of replication at replication origins determines when and where in the genome replication machines, replisomes, are generated. Tight control of replication initiation helps facilitate the two main tasks of genome replication, to ...
Eman Zaffar, Pedro Ferreira, Luis Sanchez-Pulido, Dominik Boos   +3 more
doaj   +2 more sources

Neural network and kinetic modelling of human genome replication reveal replication origin locations and strengths. [PDF]

PLoS Computational Biology, 2023
In human and other metazoans, the determinants of replication origin location and strength are still elusive. Origins are licensed in G1 phase and fired in S phase of the cell cycle, respectively.
Jean-Michel Arbona, Hadi Kabalane, Jeremy Barbier, Arach Goldar, Olivier Hyrien, Benjamin Audit   +5 more
doaj   +2 more sources

An Orc1 initiator-specific motif (ISM)-related region limits ORC–ssDNA binding and promotes replication origin specificity in budding yeast [PDF]

Frontiers in Microbiology
Single-stranded DNA (ssDNA) is an essential intermediate of genome duplication but can also arise in the genome, including at highly transcribed loci. Although the origin recognition complex (ORC), a eukaryotic replication initiator, has been reported to
Hironori Kawakami, Hironori Kawakami, Takeaki Chichibu, Ryuya Muraoka, Shota Kanamoto, Kanako Asada, Eiji Ohashi, Takuya Kurihara, Tsutomu Katayama   +8 more
doaj   +2 more sources

Dynamics of replication origin over-activation [PDF]

Nature Communications, 2021
DNA replication processes are often dysregulated in cancer. Here the authors analyse DNA synthesis patterns in cancer cells undergoing partial genome re-replication to reveal that re-replication exhibits aberrant replication fork dynamics and a skewed ...
Haiqing Fu, Christophe E. Redon, Bhushan L. Thakur, Koichi Utani, Robin Sebastian, Sang-Min Jang, Jacob M. Gross, Sara Mosavarpour, Anna B. Marks, Sophie Z. Zhuang, Sarah B. Lazar, Mishal Rao, Shira T. Mencer, Adrian M. Baris, Lorinc S. Pongor, Mirit I. Aladjem   +15 more
doaj   +2 more sources

Binding of the Treslin-MTBP Complex to Specific Regions of the Human Genome Promotes the Initiation of DNA Replication

Cell Reports, 2020
Summary: The processes that control where higher eukaryotic cells initiate DNA replication throughout the genome are not understood clearly. In metazoans, the Treslin-MTBP complex mediates critical final steps in formation of the activated replicative ...
Akiko Kumagai, William G. Dunphy
doaj   +1 more source

Blocking, Bending, and Binding: Regulation of Initiation of Chromosome Replication During the Escherichia coli Cell Cycle by Transcriptional Modulators That Interact With Origin DNA

Frontiers in Microbiology, 2021
Genome duplication is a critical event in the reproduction cycle of every cell. Because all daughter cells must inherit a complete genome, chromosome replication is tightly regulated, with multiple mechanisms focused on controlling when chromosome ...
Julia E. Grimwade, Alan C. Leonard
doaj   +1 more source

An explanation for origin unwinding in eukaryotes

eLife, 2019
Twin CMG complexes are assembled head-to-head around duplex DNA at eukaryotic origins of replication. Mcm10 activates CMGs to form helicases that encircle single-strand (ss) DNA and initiate bidirectional forks.
Lance D Langston, Michael E O'Donnell
doaj   +1 more source

Initiation of DNA replication from non-canonical sites on an origin-depleted chromosome. [PDF]

PLoS ONE, 2014
Eukaryotic DNA replication initiates from multiple sites on each chromosome called replication origins (origins). In the budding yeast Saccharomyces cerevisiae, origins are defined at discrete sites.
Naomi L Bogenschutz, Jairo Rodriguez, Toshio Tsukiyama   +2 more
doaj   +1 more source

A Lineage of Begomoviruses Encode Rep and AC4 Proteins of Enigmatic Ancestry: Hints on the Evolution of Geminiviruses in the New World

Viruses, 2019
The begomoviruses (BGVs) are plant pathogens that evolved in the Old World during the Cretaceous and arrived to the New World (NW) in the Cenozoic era.
Sandra Iliana Torres-Herrera, Angélica Romero-Osorio, Oscar Moreno-Valenzuela, Guillermo Pastor-Palacios, Yair Cardenas-Conejo, Jorge H. Ramírez-Prado, Lina Riego-Ruiz, Yereni Minero-García, Salvador Ambriz-Granados, Gerardo R. Argüello-Astorga   +9 more
doaj   +1 more source

Creating a novel origin of replication through modulating DNA-protein interfaces. [PDF]

PLoS ONE, 2010
While the molecular mechanisms of DNA-protein specificity at the origin of replication have been determined in many model organisms, these interactions remain unknown in the majority of higher eukaryotes and numerous vertebrate viruses.
F Curtis Hewitt, R Jude Samulski
doaj   +1 more source