Depletion of Uhrf1 inhibits chromosomal DNA replication in Xenopus egg extracts [PDF]
, 2013 UHRF1 (ubiquitin-like, containing PHD and RING finger domains 1) has a well-established role in epigenetic regulation through the recognition of various histone marks and interaction with chromatin-modifying proteins.
Taylor, Elaine +3 more
core +4 more sources
Mathematical modelling of whole chromosome replication [PDF]
, 2010 All chromosomes must be completely replicated prior to cell division, a requirement that demands the activation of a sufficient number of appropriately distributed DNA replication origins.
de Moura, Alessandro P.S. +4 more
core +1 more source
Viruses, 2019 The begomoviruses (BGVs) are plant pathogens that evolved in the Old World during the Cretaceous and arrived to the New World (NW) in the Cenozoic era.
Sandra Iliana Torres-Herrera +9 more
doaj +1 more source
USF binding sequences from the HS4 insulator element impose early replication timing on a vertebrate replicator [PDF]
, 2012 The nuclear genomes of vertebrates show a highly organized program of DNA replication where GC-rich isochores are replicated early in S-phase, while AT-rich isochores are late replicating.
Chilaka, S. +20 more
core +2 more sources
Changing Perspectives on the Role of DnaA-ATP in Orisome Function and Timing Regulation
Frontiers in Microbiology, 2019 Bacteria, like all cells, must precisely duplicate their genomes before they divide. Regulation of this critical process focuses on forming a pre-replicative nucleoprotein complex, termed the orisome.
Alan C. Leonard +3 more
doaj +1 more source
Initiation of DNA replication from non-canonical sites on an origin-depleted chromosome. [PDF]
PLoS ONE, 2014 Eukaryotic DNA replication initiates from multiple sites on each chromosome called replication origins (origins). In the budding yeast Saccharomyces cerevisiae, origins are defined at discrete sites.
Naomi L Bogenschutz +2 more
doaj +1 more source
The origin of replicators and reproducers [PDF]
Philosophical Transactions of the Royal Society B: Biological Sciences, 2006 Replicators are fundamental to the origin of life and evolvability. Their survival depends on the accuracy of replication and the efficiency of growth relative to spontaneous decay. Infrabiological systems are built of two coupled autocatalytic systems, in contrast to minimal living systems that must comprise at least a metabolic subsystem, a ...
openaire +2 more sources
A Dynamic Stochastic Model for DNA Replication Initiation in Early Embryos [PDF]
, 2008 Background: Eukaryotic cells seem unable to monitor replication completion during normal S phase, yet must ensure a reliable replication completion time.
Labit, H +7 more
core +2 more sources
Creating a novel origin of replication through modulating DNA-protein interfaces. [PDF]
PLoS ONE, 2010 While the molecular mechanisms of DNA-protein specificity at the origin of replication have been determined in many model organisms, these interactions remain unknown in the majority of higher eukaryotes and numerous vertebrate viruses.
F Curtis Hewitt, R Jude Samulski
doaj +1 more source
Identification of ORC1/CDC6-interacting factors in trypanosoma brucei reveals critical features of origin recognition complex architecture [PDF]
, 2012 DNA Replication initiates by formation of a pre-replication complex on sequences termed origins. In eukaryotes, the pre-replication complex is composed of the Origin Recognition Complex (ORC), Cdc6 and the MCM replicative helicase in conjunction with ...
Tiengwe Calvin +51 more
core +1 more source