Results 11 to 20 of about 247,162 (311)
DNA replication origins in archaea [PDF]
Frontiers in Microbiology, 2014 DNA replication initiation, which starts at specific chromosomal site (known as replication origins), is the key regulatory stage of chromosome replication.
Zhenfang eWu +5 more
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High-Resolution Replication Profiles Define the Stochastic Nature of Genome Replication Initiation and Termination [PDF]
Cell Reports, 2013 Eukaryotic genome replication is stochastic, and each cell uses a different cohort of replication origins. We demonstrate that interpreting high-resolution Saccharomyces cerevisiae genome replication data with a mathematical model allows quantification ...
Michelle Hawkins +6 more
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Cold Spring Harbor Perspectives in Biology, 2013 The onset of genomic DNA synthesis requires precise interactions of specialized initiator proteins with DNA at sites where the replication machinery can be loaded. These sites, defined as replication origins, are found at a few unique locations in all of the prokaryotic chromosomes examined so far.
A. C. Leonard, M. Mechali
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PLOS Genetics, 2019 In all kingdoms of life, DNA is used to encode hereditary information. Propagation of the genetic material between generations requires timely and accurate duplication of DNA by semiconservative replication prior to cell division to ensure each daughter cell receives the full complement of chromosomes.
Babatunde Ekundayo, Franziska Bleichert
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Mathematical modelling of whole chromosome replication [PDF]
, 2010 All chromosomes must be completely replicated prior to cell division, a requirement that demands the activation of a sufficient number of appropriately distributed DNA replication origins.
de Moura, Alessandro P.S. +4 more
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Regulation of Replication Origins [PDF]
, 2017 In eukaryotes, genome duplication starts concomitantly at many replication initiation sites termed replication origins. The replication initiation program is spatially and temporally coordinated to ensure accurate, efficient DNA synthesis that duplicates the entire genome while maintaining other chromatin-dependent functions. Unlike in prokaryotes, not
Anna B, Marks +2 more
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USF binding sequences from the HS4 insulator element impose early replication timing on a vertebrate replicator [PDF]
, 2012 The nuclear genomes of vertebrates show a highly organized program of DNA replication where GC-rich isochores are replicated early in S-phase, while AT-rich isochores are late replicating.
Chilaka, S. +20 more
core +1 more source
Changing Perspectives on the Role of DnaA-ATP in Orisome Function and Timing Regulation
Frontiers in Microbiology, 2019 Bacteria, like all cells, must precisely duplicate their genomes before they divide. Regulation of this critical process focuses on forming a pre-replicative nucleoprotein complex, termed the orisome.
Alan C. Leonard +3 more
doaj +1 more source
The origin of replicators and reproducers [PDF]
Philosophical Transactions of the Royal Society B: Biological Sciences, 2006 Replicators are fundamental to the origin of life and evolvability. Their survival depends on the accuracy of replication and the efficiency of growth relative to spontaneous decay. Infrabiological systems are built of two coupled autocatalytic systems, in contrast to minimal living systems that must comprise at least a metabolic subsystem, a ...
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Identification of ORC1/CDC6-interacting factors in trypanosoma brucei reveals critical features of origin recognition complex architecture [PDF]
, 2012 DNA Replication initiates by formation of a pre-replication complex on sequences termed origins. In eukaryotes, the pre-replication complex is composed of the Origin Recognition Complex (ORC), Cdc6 and the MCM replicative helicase in conjunction with ...
Tiengwe Calvin +51 more
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